Prion disease and the 'protein-only hypothesis'.
Essays Biochem. 2014;56:181-91. doi: 10.1042/bse0560181.
Essays Biochem. 2014.
PMID: 25131595
Free PMC article.
Review.
Prion disease is the only naturally occurring infectious protein misfolding disorder. The chemical nature of the infectious agent has been debated for more than half a century. Early studies on scrapie suggested that the unusual infectious agent …
Prion disease is the only naturally occurring infectious protein misfolding disorder. The chemical nature of the infectious …