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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 1
1952 1
1953 2
1955 2
1957 2
1959 2
1960 1
1961 4
1963 4
1964 3
1965 5
1966 3
1967 7
1968 4
1969 7
1970 7
1971 11
1972 8
1973 9
1974 9
1975 11
1976 11
1977 14
1978 18
1979 8
1980 17
1981 14
1982 20
1983 23
1984 21
1985 18
1986 12
1987 32
1988 22
1989 20
1990 19
1991 23
1992 23
1993 18
1994 26
1995 19
1996 16
1997 20
1998 17
1999 10
2000 7
2001 19
2002 15
2003 17
2004 9
2005 21
2006 11
2007 22
2008 9
2009 23
2010 26
2011 20
2012 21
2013 34
2014 31
2015 32
2016 40
2017 29
2018 39
2019 24
2020 37
2021 2
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973 results
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Page 1
Recent advances in intestinal alkaline phosphatase, inflammation, and nutrition.
Lallès JP. Lallès JP. Nutr Rev. 2019 Oct 1;77(10):710-724. doi: 10.1093/nutrit/nuz015. Nutr Rev. 2019. PMID: 31086953 Review.
In recent years, much new data on intestinal alkaline phosphatase (IAP) have been published, and major breakthroughs have been disclosed. ...Many recent papers have also explored the prophylactic and therapeutic potential of IAP and other alkaline p …
In recent years, much new data on intestinal alkaline phosphatase (IAP) have been published, and major breakthroughs ha …
The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract.
Bilski J, Mazur-Bialy A, Wojcik D, Zahradnik-Bilska J, Brzozowski B, Magierowski M, Mach T, Magierowska K, Brzozowski T. Bilski J, et al. Mediators Inflamm. 2017;2017:9074601. doi: 10.1155/2017/9074601. Epub 2017 Feb 21. Mediators Inflamm. 2017. PMID: 28316376 Free PMC article. Review.
Over the past few years, the role of intestinal alkaline phosphatase (IAP) as a crucial mucosal defence factor essential for maintaining gut homeostasis has been established. ...Diminished activity of IAP could increase the risk of disease through changes in …
Over the past few years, the role of intestinal alkaline phosphatase (IAP) as a crucial mucosal defence factor essentia …
Alkaline phosphatase: an overview.
Sharma U, Pal D, Prasad R. Sharma U, et al. Indian J Clin Biochem. 2014 Jul;29(3):269-78. doi: 10.1007/s12291-013-0408-y. Epub 2013 Nov 26. Indian J Clin Biochem. 2014. PMID: 24966474 Free PMC article. Review.
Alkaline phosphatase is divided into four isozymes depending upon the site of tissue expression that are Intestinal ALP, Placental ALP, Germ cell ALP and tissue nonspecific alkaline phosphatase or liver/bone/kidney (L/B/K) ALP. ...In this review …
Alkaline phosphatase is divided into four isozymes depending upon the site of tissue expression that are Intestinal ALP …
Intestinal alkaline phosphatase targets the gut barrier to prevent aging.
Kühn F, Adiliaghdam F, Cavallaro PM, Hamarneh SR, Tsurumi A, Hoda RS, Munoz AR, Dhole Y, Ramirez JM, Liu E, Vasan R, Liu Y, Samarbafzadeh E, Nunez RA, Farber MZ, Chopra V, Malo MS, Rahme LG, Hodin RA. Kühn F, et al. JCI Insight. 2020 Mar 26;5(6):e134049. doi: 10.1172/jci.insight.134049. JCI Insight. 2020. PMID: 32213701 Free PMC article.
Gut barrier dysfunction and gut-derived chronic inflammation play crucial roles in human aging. The gut brush border enzyme intestinal alkaline phosphatase (IAP) functions to inhibit inflammatory mediators and also appears to be an important positive regulato …
Gut barrier dysfunction and gut-derived chronic inflammation play crucial roles in human aging. The gut brush border enzyme intestinal …
Alkaline Phosphatase.
Lowe D, Sanvictores T, John S. Lowe D, et al. 2020 Aug 30. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. StatPearls. 2020 Jan–. PMID: 29083622 Free Books & Documents. Review.
In the liver, alkaline phosphatase is cytosolic and present in the canalicular membrane of the hepatocyte. ...A single gene encodes it and is expressed in the liver, bone, and kidneys. Intestinal alkaline phosphatase is coded by a separate gene, …
In the liver, alkaline phosphatase is cytosolic and present in the canalicular membrane of the hepatocyte. ...A single gene en …
Intestinal Alkaline Phosphatase Deficiency Is Associated with Ischemic Heart Disease.
Malo J, Alam MJ, Shahnaz M, Kaliannan K, Chandra G, Aziz T, Sarker T, Bala M, Paul R, Saha CK, Karmakar PK, Malo MS. Malo J, et al. Dis Markers. 2019 Dec 13;2019:8473565. doi: 10.1155/2019/8473565. eCollection 2019. Dis Markers. 2019. PMID: 31915470 Free PMC article.
BACKGROUND: We have previously shown that the deficiency of the gut enzyme intestinal alkaline phosphatase (IAP) is associated with type 2 diabetes mellitus (T2DM) in humans, and mice deficient in IAP develop the metabolic syndrome, a precipitant of T2DM and …
BACKGROUND: We have previously shown that the deficiency of the gut enzyme intestinal alkaline phosphatase (IAP) is ass …
Intestinal alkaline phosphatase: a summary of its role in clinical disease.
Fawley J, Gourlay DM. Fawley J, et al. J Surg Res. 2016 May 1;202(1):225-34. doi: 10.1016/j.jss.2015.12.008. Epub 2015 Dec 17. J Surg Res. 2016. PMID: 27083970 Free PMC article. Review.
Over the past few years, there is increasing evidence implicating a novel role for Intestinal Alkaline Phosphatase (IAP) in mitigating inflammatory mediated disorders. IAP is an endogenous protein expressed by the intestinal epithelium that is believed …
Over the past few years, there is increasing evidence implicating a novel role for Intestinal Alkaline Phosphatase (IAP …
Intestinal alkaline phosphatase to treat necrotizing enterocolitis.
Biesterveld BE, Koehler SM, Heinzerling NP, Rentea RM, Fredrich K, Welak SR, Gourlay DM. Biesterveld BE, et al. J Surg Res. 2015 Jun 15;196(2):235-40. doi: 10.1016/j.jss.2015.02.030. Epub 2015 Feb 19. J Surg Res. 2015. PMID: 25840489 Free PMC article.
BACKGROUND: Intestinal alkaline phosphatase (IAP) activity is decreased in necrotizing enterocolitis (NEC), and IAP supplementation prevents NEC development. ...IAP and interleukin-6 expression were measured using real time polymerase chain reaction. RESULTS: …
BACKGROUND: Intestinal alkaline phosphatase (IAP) activity is decreased in necrotizing enterocolitis (NEC), and IAP sup …
Intestinal Alkaline Phosphatase Exerts Anti-Inflammatory Effects Against Lipopolysaccharide by Inducing Autophagy.
Singh SB, Carroll-Portillo A, Coffman C, Ritz NL, Lin HC. Singh SB, et al. Sci Rep. 2020 Feb 20;10(1):3107. doi: 10.1038/s41598-020-59474-6. Sci Rep. 2020. PMID: 32080230 Free PMC article.
Intestinal alkaline phosphatase (IAP) regulates bicarbonate secretion, detoxifies lipopolysaccharide (LPS), regulates gut microbes, and dephosphorylates proinflammatory nucleotides. ...We tested the hypothesis that IAP may induce autophagy which may mediate t …
Intestinal alkaline phosphatase (IAP) regulates bicarbonate secretion, detoxifies lipopolysaccharide (LPS), regulates g …
Effects of intestinal alkaline phosphatase on intestinal barrier function in a cecal ligation and puncture (CLP)-induced mouse model for sepsis.
Plaeke P, De Man JG, Smet A, Malhotra-Kumar S, Pintelon I, Timmermans JP, Nullens S, Jorens PG, Hubens G, De Winter BY. Plaeke P, et al. Neurogastroenterol Motil. 2020 Mar;32(3):e13754. doi: 10.1111/nmo.13754. Epub 2019 Nov 21. Neurogastroenterol Motil. 2020. PMID: 31751495
BACKGROUND: Sepsis is a severe pathological condition associated with systemic inflammation, intestinal inflammation, and gastrointestinal barrier dysfunction. Intestinal alkaline phosphatase (IAP) has been demonstrated to detoxify lipopolysaccharide, …
BACKGROUND: Sepsis is a severe pathological condition associated with systemic inflammation, intestinal inflammation, and gastrointes …
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