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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1957 1
1958 1
1963 1
1964 2
1966 1
1967 2
1970 2
1971 2
1972 4
1973 2
1974 1
1975 3
1976 5
1977 7
1978 6
1979 6
1980 8
1981 7
1982 13
1983 17
1984 25
1985 32
1986 37
1987 41
1988 39
1989 50
1990 50
1991 51
1992 63
1993 54
1994 57
1995 58
1996 91
1997 70
1998 81
1999 95
2000 87
2001 115
2002 89
2003 100
2004 99
2005 90
2006 127
2007 113
2008 166
2009 166
2010 157
2011 189
2012 248
2013 288
2014 284
2015 338
2016 362
2017 448
2018 470
2019 527
2020 610
2021 3
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5,488 results
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Page 1
Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut.
Michielan A, D'Incà R. Michielan A, et al. Mediators Inflamm. 2015;2015:628157. doi: 10.1155/2015/628157. Epub 2015 Oct 25. Mediators Inflamm. 2015. PMID: 26582965 Free PMC article. Review.
The pathogenesis of inflammatory bowel disease (IBD) is multifactorial with data suggesting the role of a disturbed interaction between the gut and the intestinal microbiota. A defective mucosal barrier may result in increased intestinal permeability w …
The pathogenesis of inflammatory bowel disease (IBD) is multifactorial with data suggesting the role of a disturbed interaction between the …
Leaky Gut, Leaky Brain?
Obrenovich MEM. Obrenovich MEM. Microorganisms. 2018 Oct 18;6(4):107. doi: 10.3390/microorganisms6040107. Microorganisms. 2018. PMID: 30340384 Free PMC article. Review.
'Leaky gut' syndrome, long-associated with celiac disease, has attracted much attention in recent years and for decades, was widely known in complementary/alternative medicine circles. ...This mini-review focuses on the possible neurophysiological basis of leaky
'Leaky gut' syndrome, long-associated with celiac disease, has attracted much attention in recent years and for decades, was w …
Leaky gut: mechanisms, measurement and clinical implications in humans.
Camilleri M. Camilleri M. Gut. 2019 Aug;68(8):1516-1526. doi: 10.1136/gutjnl-2019-318427. Epub 2019 May 10. Gut. 2019. PMID: 31076401 Free PMC article. Review.
The objectives of this review on 'leaky gut' for clinicians are to discuss the components of the intestinal barrier, the diverse measurements of intestinal permeability, their perturbation in non-inflammatory 'stressed states' and the impact of …
The objectives of this review on 'leaky gut' for clinicians are to discuss the components of the intestinal barrier, th …
Leaky gut - concept or clinical entity?
Quigley EM. Quigley EM. Curr Opin Gastroenterol. 2016 Mar;32(2):74-9. doi: 10.1097/MOG.0000000000000243. Curr Opin Gastroenterol. 2016. PMID: 26760399 Review.
PURPOSE OF REVIEW: This article evaluates the current status of the gut barrier in gastrointestinal disorders. RECENT FINDINGS: The gut barrier is a complex, multicomponent, interactive, and bidirectional entity that includes, but is not restricted to, the epithelia …
PURPOSE OF REVIEW: This article evaluates the current status of the gut barrier in gastrointestinal disorders. RECENT FINDINGS: The …
Alzheimer's disease and gut microbiota.
Hu X, Wang T, Jin F. Hu X, et al. Sci China Life Sci. 2016 Oct;59(10):1006-1023. doi: 10.1007/s11427-016-5083-9. Epub 2016 Aug 26. Sci China Life Sci. 2016. PMID: 27566465 Review.
Germ-free animals, antibiotics, probiotics intervention and diet can induce alterations of gut microbiota and gut physiology and also host cognitive behavior, increasing or decreasing risks of AD. The increased permeability of intestine and blood-brain barrie …
Germ-free animals, antibiotics, probiotics intervention and diet can induce alterations of gut microbiota and gut physiology a …
Lubiprostone improves intestinal permeability in humans, a novel therapy for the leaky gut: A prospective randomized pilot study in healthy volunteers.
Kato T, Honda Y, Kurita Y, Iwasaki A, Sato T, Kessoku T, Uchiyama S, Ogawa Y, Ohkubo H, Higurashi T, Yamanaka T, Usuda H, Wada K, Nakajima A. Kato T, et al. PLoS One. 2017 Apr 14;12(4):e0175626. doi: 10.1371/journal.pone.0175626. eCollection 2017. PLoS One. 2017. PMID: 28410406 Free PMC article. Clinical Trial.
As such, a method to prevent leaky gut syndrome would have substantial clinical value. However, no drugs have been demonstrated to improve disturbed intestinal permeability in humans to date. ...CONCLUSIONS: This study is the first to report an improve …
As such, a method to prevent leaky gut syndrome would have substantial clinical value. However, no drugs have been demonstrate …
Leaky Gut As a Danger Signal for Autoimmune Diseases.
Mu Q, Kirby J, Reilly CM, Luo XM. Mu Q, et al. Front Immunol. 2017 May 23;8:598. doi: 10.3389/fimmu.2017.00598. eCollection 2017. Front Immunol. 2017. PMID: 28588585 Free PMC article. Review.
In pathologic conditions, the permeability of the epithelial lining may be compromised allowing the passage of toxins, antigens, and bacteria in the lumen to enter the blood stream creating a "leaky gut." ...Therefore, it is hypothesized that modulating the …
In pathologic conditions, the permeability of the epithelial lining may be compromised allowing the passage of toxins, antigens, and …
Retinoic Acid, Leaky Gut, and Autoimmune Diseases.
Abdelhamid L, Luo XM. Abdelhamid L, et al. Nutrients. 2018 Aug 3;10(8):1016. doi: 10.3390/nu10081016. Nutrients. 2018. PMID: 30081517 Free PMC article. Review.
A leaky gut has been observed in a number of autoimmune diseases including type 1 diabetes, multiple sclerosis, inflammatory bowel disease, and systemic lupus erythematosus. Previous studies from our laboratory have shown that lupus mice also bear a leaky
A leaky gut has been observed in a number of autoimmune diseases including type 1 diabetes, multiple sclerosis, inflammatory b …
Intestinal permeability defects: is it time to treat?
Odenwald MA, Turner JR. Odenwald MA, et al. Clin Gastroenterol Hepatol. 2013 Sep;11(9):1075-83. doi: 10.1016/j.cgh.2013.07.001. Epub 2013 Jul 12. Clin Gastroenterol Hepatol. 2013. PMID: 23851019 Free PMC article. Review.
Although most available data are correlative, some studies support a model where cycles of increased intestinal permeability, intestinal immune activation, and subsequent immune-mediated barrier loss contribute to disease progression. ...Nevertheless, the cor …
Although most available data are correlative, some studies support a model where cycles of increased intestinal permeability, …
Gut Microbiome, Intestinal Permeability, and Tissue Bacteria in Metabolic Disease: Perpetrators or Bystanders?
Chakaroun RM, Massier L, Kovacs P. Chakaroun RM, et al. Nutrients. 2020 Apr 14;12(4):1082. doi: 10.3390/nu12041082. Nutrients. 2020. PMID: 32295104 Free PMC article. Review.
Mounting preclinical and clinical evidence of gut microbiota shifts, increased intestinal permeability in metabolic disease, and the critical positioning of the intestinal barrier at the interface between environment and internal milieu have led to the …
Mounting preclinical and clinical evidence of gut microbiota shifts, increased intestinal permeability in metabolic dis …
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