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Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders.
Chopyk DM, Grakoui A. Chopyk DM, et al. Gastroenterology. 2020 Sep;159(3):849-863. doi: 10.1053/j.gastro.2020.04.077. Epub 2020 Jun 20. Gastroenterology. 2020. PMID: 32569766 Review.
Intestinal barrier dysfunction and dysbiosis contribute to development of diseases in liver and other organs. ...We review the mechanisms that regulate intestinal permeability and how changes in the intestinal microbiome contribute to development of ac
Intestinal barrier dysfunction and dysbiosis contribute to development of diseases in liver and other organs. ...We review the mechan
Role of Gut Dysbiosis in Liver Diseases: What Have We Learned So Far?
Fukui H. Fukui H. Diseases. 2019 Nov 12;7(4):58. doi: 10.3390/diseases7040058. Diseases. 2019. PMID: 31726747 Free PMC article. Review.
Accumulating evidence supports that gut dysbiosis may relate to various liver diseases. Alcoholics with high intestinal permeability had a decrease in the abundance of Ruminnococcus. Intestinal dysmotility, increased gastric pH, and altered immune resp …
Accumulating evidence supports that gut dysbiosis may relate to various liver diseases. Alcoholics with high intestinal per
New Therapeutic Targets in Autoimmune Cholangiopathies.
Gerussi A, Lucà M, Cristoferi L, Ronca V, Mancuso C, Milani C, D'Amato D, O'Donnell SE, Carbone M, Invernizzi P. Gerussi A, et al. Front Med (Lausanne). 2020 Apr 7;7:117. doi: 10.3389/fmed.2020.00117. eCollection 2020. Front Med (Lausanne). 2020. PMID: 32318580 Free PMC article. Review.
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are autoimmune cholangiopathies characterized by limited treatment options. ...Conversely, different pathogenetic models have been proposed in PSC such as the "leaky
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are autoimmune cholangiopathie
The Role of the Intestine in the Pathogenesis of Primary Sclerosing Cholangitis: Evidence and Therapeutic Implications.
Dean G, Hanauer S, Levitsky J. Dean G, et al. Hepatology. 2020 Sep;72(3):1127-1138. doi: 10.1002/hep.31311. Hepatology. 2020. PMID: 32394535 Review.
The pathogenesis of primary sclerosing cholangitis (PSC), a progressive biliary tract disease without approved medical therapy, is not well understood. ...The link between these mechanisms may be related to altered intestinal permeability leadin …
The pathogenesis of primary sclerosing cholangitis (PSC), a progressive biliary tract disease without approved medical …
Inflammation and the Gut-Liver Axis in the Pathophysiology of Cholangiopathies.
Giordano DM, Pinto C, Maroni L, Benedetti A, Marzioni M. Giordano DM, et al. Int J Mol Sci. 2018 Oct 1;19(10):3003. doi: 10.3390/ijms19103003. Int J Mol Sci. 2018. PMID: 30275402 Free PMC article. Review.
Gut microbiota has been implicated in the development and progression of the two most common cholangiopathies, i.e., primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), which have distinctive microbiota composition
Gut microbiota has been implicated in the development and progression of the two most common cholangiopathies, i.e., primary
[Gut-liver axis: How intestinal bacteria affect the liver].
Konturek PC, Harsch IA, Konturek K, Schink M, Zopf Y. Konturek PC, et al. MMW Fortschr Med. 2018 Nov;160(Suppl 5):11-15. doi: 10.1007/s15006-018-1051-6. Epub 2018 Oct 26. MMW Fortschr Med. 2018. PMID: 30367438 Review. German.
BACKGROUND: Liver and intestine are in close contact with each other. The risk of damage to the liver increases, when the intestinal barrier is damaged ("leaky gut") . METHOD: The review article describes how intestinal bacteria influence the pathogene …
BACKGROUND: Liver and intestine are in close contact with each other. The risk of damage to the liver increases, when the intestinal
Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic gammadelta T-Cell Receptor-Positive Cells and Pathogenesis of Cholestatic Liver Disease.
Tedesco D, Thapa M, Chin CY, Ge Y, Gong M, Li J, Gumber S, Speck P, Elrod EJ, Burd EM, Kitchens WH, Magliocca JF, Adams AB, Weiss DS, Mohamadzadeh M, Grakoui A. Tedesco D, et al. Gastroenterology. 2018 Jun;154(8):2178-2193. doi: 10.1053/j.gastro.2018.02.019. Epub 2018 Feb 15. Gastroenterology. 2018. PMID: 29454797 Free PMC article.
We obtained tissues from 10 patients undergoing liver transplantation for primary sclerosing cholangitis or chronic hepatitis C virus infection. ...Intravenous injections of Mdr2(-/-) mice with anti-gammadelta TCR reduced fibrosis; liver levels of IL17, and i …
We obtained tissues from 10 patients undergoing liver transplantation for primary sclerosing cholangitis or chronic hep …
Intestinal permeability and bacterial growth of the small bowel in patients with primary sclerosing cholangitis.
Björnsson E, Cederborg A, Akvist A, Simren M, Stotzer PO, Bjarnason I. Björnsson E, et al. Scand J Gastroenterol. 2005 Sep;40(9):1090-4. doi: 10.1080/00365520510023288. Scand J Gastroenterol. 2005. PMID: 16211716
Intestinal permeability in patients with primary sclerosing cholangitis (0.034 (0.026-0.041) (median, interquartile range (IQR)) did not differ significantly from that of the controls (0.033 (0.025-0.041). CONCLUSIONS: Small intestinal ba
Intestinal permeability in patients with primary sclerosing cholangitis (0.034 (0.026-0.041) (median, int
The intestinal microbiome and paediatric liver disease.
Leung DH, Yimlamai D. Leung DH, et al. Lancet Gastroenterol Hepatol. 2017 Jun;2(6):446-455. doi: 10.1016/S2468-1253(16)30241-2. Lancet Gastroenterol Hepatol. 2017. PMID: 28497760 Review.
The microbiome regulates intestinal permeability and helps to metabolise the human diet into small molecules, thus directly affecting liver health. Several studies have linked intestinal dysbiosis to the severity and progression of liver diseases, such as non …
The microbiome regulates intestinal permeability and helps to metabolise the human diet into small molecules, thus directly af …
Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis.
Dhillon AK, Kummen M, Trøseid M, Åkra S, Liaskou E, Moum B, Vesterhus M, Karlsen TH, Seljeflot I, Hov JR. Dhillon AK, et al. Liver Int. 2019 Feb;39(2):371-381. doi: 10.1111/liv.13979. Epub 2018 Oct 24. Liver Int. 2019. PMID: 30269440
BACKGROUND & AIMS: One important hypothesis in primary sclerosing cholangitis pathophysiology suggests that bacterial products from an inflamed leaky gut lead to biliary inflammation. ...The concentration of soluble CD14 was higher in patien …
BACKGROUND & AIMS: One important hypothesis in primary sclerosing cholangitis pathophysiology suggests that bacteri …
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