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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1986 1
1990 1
1992 1
1995 2
1996 2
1998 1
1999 2
2001 4
2004 1
2005 1
2006 5
2007 2
2008 1
2009 6
2010 7
2011 5
2012 2
2013 14
2014 10
2015 4
2016 5
2017 2
2018 1
2019 2
2020 6
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84 results
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Page 1
Does exposure to isotretinoin increase the risk for the development of inflammatory bowel disease? A meta-analysis.
Lee SY, Jamal MM, Nguyen ET, Bechtold ML, Nguyen DL. Lee SY, et al. Eur J Gastroenterol Hepatol. 2016 Feb;28(2):210-6. doi: 10.1097/MEG.0000000000000496. Eur J Gastroenterol Hepatol. 2016. PMID: 26545085 Review.
BACKGROUND: Isotretinoin is a treatment option for severe nodulocystic acne. However, its use has inconsistently been associated with the development of inflammatory bowel disease (IBD). ...CONCLUSION: Isotretinoin exposure is not associated wit …
BACKGROUND: Isotretinoin is a treatment option for severe nodulocystic acne. However, its use has inconsistently been associated with …
Clarifying the Purported Association between Isotretinoin and Inflammatory Bowel Disease.
Coughlin SS. Coughlin SS. J Environ Health Sci. 2015;1(2):10.15436/2378-6841.15.007. doi: 10.15436/2378-6841.15.007. J Environ Health Sci. 2015. PMID: 26345605 Free PMC article.
Isotretinoin was approved by the Food and Drug Administration (FDA) in 1982 and revolutionized acne therapy. Soon afterwards, case reports appeared suggesting a link between inflammatory bowel disease and use of isotretinoin. ...Although epidemi
Isotretinoin was approved by the Food and Drug Administration (FDA) in 1982 and revolutionized acne therapy. Soon afterwards, case re
Isotretinoin: controversies, facts, and recommendations.
Bauer LB, Ornelas JN, Elston DM, Alikhan A. Bauer LB, et al. Expert Rev Clin Pharmacol. 2016 Nov;9(11):1435-1442. doi: 10.1080/17512433.2016.1213629. Epub 2016 Jul 29. Expert Rev Clin Pharmacol. 2016. PMID: 27414637 Review.
However, it has also been surrounded by controversy due to its teratogenicity and inconsistent associations with depression, suicidality, inflammatory bowel disease, increases in lipid levels, and elevated transaminases. ...Expert commentary: Despite common m …
However, it has also been surrounded by controversy due to its teratogenicity and inconsistent associations with depression, suicidality, …
Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity.
Melnik BC. Melnik BC. Acta Derm Venereol. 2017 Feb 8;97(2):173-181. doi: 10.2340/00015555-2535. Acta Derm Venereol. 2017. PMID: 27671426 Free article. Review.
Furthermore, apoptosis may be the underlying and unifying mechanism of the adverse effects of isotretinoin on neural crest cells (teratogenicity), hippocampal neurones (depression), epidermal keratinocytes and mucosa cells (mucocutaneous side-effects), hair follicle cells …
Furthermore, apoptosis may be the underlying and unifying mechanism of the adverse effects of isotretinoin on neural crest cells (ter …
Isotretinoin-induced inflammatory bowel disease.
Passier JL, Srivastava N, van Puijenbroek EP. Passier JL, et al. Neth J Med. 2006 Feb;64(2):52-4. Neth J Med. 2006. PMID: 16517990 Free article.
Three case reports on inflammatory bowel disease associated with use of isotretinoin are described. All three patients were male adolescents, in good health when starting isotretinoin (for acne treatment for about six months). ...Although inf
Three case reports on inflammatory bowel disease associated with use of isotretinoin are described. All three pa …
Isotretinoin is not associated with inflammatory bowel disease: a population-based case-control study.
Bernstein CN, Nugent Z, Longobardi T, Blanchard JF. Bernstein CN, et al. Am J Gastroenterol. 2009 Nov;104(11):2774-8. doi: 10.1038/ajg.2009.417. Epub 2009 Jul 21. Am J Gastroenterol. 2009. PMID: 19623167
OBJECTIVES: There is anecdotal evidence that isotretinoin use is associated with development of colitis. We aimed at determining whether there is an association between isotretinoin use and development of inflammatory bowel disease (IBD). ...Thi …
OBJECTIVES: There is anecdotal evidence that isotretinoin use is associated with development of colitis. We aimed at determining whet …
Isotretinoin exposure and risk of inflammatory bowel disease.
Rashtak S, Khaleghi S, Pittelkow MR, Larson JJ, Lahr BD, Murray JA. Rashtak S, et al. JAMA Dermatol. 2014 Dec;150(12):1322-6. doi: 10.1001/jamadermatol.2014.1540. JAMA Dermatol. 2014. PMID: 25207875
IMPORTANCE Isotretinoin is the standard treatment for refractory severe nodulocystic acne.A true association between prior isotretinoin use and development of inflammatory bowel disease (IBD) is uncertain. ...Inflammatory bowel
IMPORTANCE Isotretinoin is the standard treatment for refractory severe nodulocystic acne.A true association between prior isotret
Drug-induced inflammatory bowel disease and IBD-like conditions.
Dubeau MF, Iacucci M, Beck PL, Moran GW, Kaplan GG, Ghosh S, Panaccione R. Dubeau MF, et al. Inflamm Bowel Dis. 2013 Feb;19(2):445-56. doi: 10.1002/ibd.22990. Inflamm Bowel Dis. 2013. PMID: 22573536 Review.
The pathogenesis of inflammatory bowel disease (IBD) is multifactorial and results from an interaction between genetic, immunologic, microbial, and environmental factors. Certain drugs could act as a trigger for the disease and have been implicated in …
The pathogenesis of inflammatory bowel disease (IBD) is multifactorial and results from an interaction between genetic, …
[Second joint position paper: Use of isotretinoin in severe acne].
Gómez-Flores M, Poletti-Vázquez DE, García-Hidalgo L, Fierro-Arias L, Herz-Ruelas M, Garza-Gómez J, Rosas-Ortiz JF. Gómez-Flores M, et al. Rev Med Inst Mex Seguro Soc. 2019 Jan 28;56(5):441-446. Rev Med Inst Mex Seguro Soc. 2019. PMID: 30777411 Spanish.
BACKGROUND: The use of isotretinoin is indicated in the treatment of severe acne; however, its adverse effects are important. ...CONCLUSIONS: Isotretinoin is still the best treatment for severe nodulocystic acne. However, it must be taken into consideration its tera …
BACKGROUND: The use of isotretinoin is indicated in the treatment of severe acne; however, its adverse effects are important. ...CONC …
A causal association between isotretinoin and inflammatory bowel disease has yet to be established.
Crockett SD, Gulati A, Sandler RS, Kappelman MD. Crockett SD, et al. Am J Gastroenterol. 2009 Oct;104(10):2387-93. doi: 10.1038/ajg.2009.334. Am J Gastroenterol. 2009. PMID: 19806085 Free PMC article. Review.
OBJECTIVES: Case reports have described a possible association between isotretinoin and inflammatory bowel disease (IBD). We critically appraised the literature on this association to assess whether it supports a causal relationship. ...Cases occurred …
OBJECTIVES: Case reports have described a possible association between isotretinoin and inflammatory bowel disease
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