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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1949 1
1951 1
1953 1
1955 1
1958 2
1961 2
1962 2
1963 3
1964 7
1965 3
1966 4
1967 6
1968 3
1969 4
1970 4
1971 5
1972 10
1973 35
1974 40
1975 38
1976 47
1977 45
1978 43
1979 42
1980 51
1981 53
1982 51
1983 49
1984 52
1985 38
1986 42
1987 38
1988 55
1989 40
1990 48
1991 48
1992 37
1993 37
1994 37
1995 39
1996 35
1997 33
1998 41
1999 29
2000 27
2001 25
2002 43
2003 30
2004 24
2005 39
2006 36
2007 41
2008 48
2009 46
2010 59
2011 54
2012 52
2013 72
2014 53
2015 61
2016 70
2017 82
2018 83
2019 82
2020 89
2021 19
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2,203 results
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Page 1
Cholestasis induced by lithocholate and its glucuronide: their biliary excretion and metabolism.
Takikawa H, Ohki H, Sano N, Kasama T, Yamanaka M. Takikawa H, et al. Biochim Biophys Acta. 1991 Jan 4;1081(1):39-44. doi: 10.1016/0005-2760(91)90247-f. Biochim Biophys Acta. 1991. PMID: 1991154
Lithocholate-glucuronide had a higher cholestatic effect than lithocholate, whereas lithocholate-sulfate had almost no effect on bile flow. ...These results suggest that the poor biotransformation of lithocholate-glucuronide is related to its higher ch …
Lithocholate-glucuronide had a higher cholestatic effect than lithocholate, whereas lithocholate-sulfate had almost no …
Lithocholate metabolism during chemotherapy for gallstone dissolution. 2. Absorption and sulphation.
Allan RN, Thistle JL, Hofmann AF. Allan RN, et al. Gut. 1976 Jun;17(6):413-9. doi: 10.1136/gut.17.6.413. Gut. 1976. PMID: 955496 Free PMC article.
The amount of lithocholate input and the size of the total lithocholate exchangeable pool were measured using isotope dilution in three patients ingesting chenodeoxycholic acid for gallstone dissolution and two healthy control subjects. ...These findings indi …
The amount of lithocholate input and the size of the total lithocholate exchangeable pool were measured using isotope dilution …
Differential effects of lithocholate on rat neutrophil activation.
Dahm LJ, Roth RA. Dahm LJ, et al. J Leukoc Biol. 1990 Jun;47(6):551-60. doi: 10.1002/jlb.47.6.551. J Leukoc Biol. 1990. PMID: 2112579
In the present study, we characterized the priming effect of lithocholate for O2- release and also examined the effects of lithocholate on enzyme release from PMNs. ...Lithocholate had no effect on PMA-stimulated lysozyme release. These results indicate that …
In the present study, we characterized the priming effect of lithocholate for O2- release and also examined the effects of lithoch …
Cytotoxic effect and uptake mechanism by isolated rat hepatocytes of lithocholate and its glucuronide and sulfate.
Takikawa H, Tomita J, Takemura T, Yamanaka M. Takikawa H, et al. Biochim Biophys Acta. 1991 Jan 31;1091(2):173-8. doi: 10.1016/0167-4889(91)90058-6. Biochim Biophys Acta. 1991. PMID: 1995077
Na+ replacement by choline+ had no effect on the uptake of lithocholate and lithocholate-glucuronide, whereas it slightly inhibited lithocholate-sulfate uptake. Lithocholate-glucuronide uptake was inhibited by lithocholate-sulfate and sulfobromo …
Na+ replacement by choline+ had no effect on the uptake of lithocholate and lithocholate-glucuronide, whereas it slightly inhi …
Development of novel lithocholic acid derivatives as vitamin D receptor agonists.
Masuno H, Kazui Y, Tanatani A, Fujii S, Kawachi E, Ikura T, Ito N, Yamamoto K, Kagechika H. Masuno H, et al. Bioorg Med Chem. 2019 Aug 15;27(16):3674-3681. doi: 10.1016/j.bmc.2019.07.003. Epub 2019 Jul 3. Bioorg Med Chem. 2019. PMID: 31300316
Lithocholic acid (2) was identified as the second endogenous ligand of vitamin D receptor (VDR), though its binding affinity to VDR and its vitamin D activity are very weak compared to those of the active metabolite of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) ( …
Lithocholic acid (2) was identified as the second endogenous ligand of vitamin D receptor (VDR), though its binding affinity t …
The effect of taurine on the cholestatic potential of sulfated lithocholate and its conjugates.
Belli DC, Roy CC, Fournier LA, Tuchweber B, Giguère R, Yousef IM. Belli DC, et al. Liver. 1991 Jun;11(3):162-9. doi: 10.1111/j.1600-0676.1991.tb00510.x. Liver. 1991. PMID: 1886461
The present study was aimed at determining whether the protection by taurine of lithocholate-sulfate-induced cholestasis is mediated by conjugation or by direct effect of the amino acid on bile formation. ...There was no decrease in bile flow after the injection of …
The present study was aimed at determining whether the protection by taurine of lithocholate-sulfate-induced cholestasis is mediated …
Metabolism of lethocholate in healthy man. I. Biotransformation and biliary excretion of intravenously administered lithocholate, lithocholylglycine, and their sulfates.
Cowen AE, Korman MG, Hofmann AF, Cass OW. Cowen AE, et al. Gastroenterology. 1975 Jul;69(1):59-66. Gastroenterology. 1975. PMID: 1150035
Lithocholate radioactivity was excreted rapidly and predominantly in bile; the excreted radioactivity had the chromatographic properties of glycine and taurine conjugates of lithocholate, of which 60% were sulfated. ...Since sulfation is not complete, some unsulfate …
Lithocholate radioactivity was excreted rapidly and predominantly in bile; the excreted radioactivity had the chromatographic propert …
Bile acid composition regulates the manganese transporter Slc30a10 in intestine.
Ahmad TR, Higuchi S, Bertaggia E, Hung A, Shanmugarajah N, Guilz NC, Gamarra JR, Haeusler RA. Ahmad TR, et al. J Biol Chem. 2020 Aug 28;295(35):12545-12558. doi: 10.1074/jbc.RA120.012792. Epub 2020 Jul 20. J Biol Chem. 2020. PMID: 32690612 Free PMC article.
We found that BA pools, especially those low in 12HBAs, induce cellular manganese efflux and that Slc30a10 induction by BA pools is driven primarily by lithocholic acid signaling via the vitamin D receptor. Administration of lithocholic acid or a vitam …
We found that BA pools, especially those low in 12HBAs, induce cellular manganese efflux and that Slc30a10 induction by BA pools is driven p …
Metabolism of lithocholate in healthy man. III. Plasma disappearance of radioactivity after intravenous injection of labeled lithocholate and its derivatives.
Cowen AE, Korman MG, Hofmann AF, Thomas PJ. Cowen AE, et al. Gastroenterology. 1975 Jul;69(1):77-82. Gastroenterology. 1975. PMID: 1150037
The plasma disappearance of intravenously injected radiolabeled lithocholate, lithocholylglycine, and their respective 3alpha-sulfates was defined in healthy subjects. ...The results indicate that lithocholate, which enters the plasma compartment, whether unconjugat …
The plasma disappearance of intravenously injected radiolabeled lithocholate, lithocholylglycine, and their respective 3alpha-sulfate …
Conjugation of bile esters to cellulose by olefin cross-metathesis: A strategy for accessing complex polysaccharide structures.
Dong Y, Novo DC, Mosquera-Giraldo LI, Taylor LS, Edgar KJ. Dong Y, et al. Carbohydr Polym. 2019 Oct 1;221:37-47. doi: 10.1016/j.carbpol.2019.05.061. Epub 2019 May 25. Carbohydr Polym. 2019. PMID: 31227165
We introduce efficient conjugation of cholesterol (as a model steroid), lithocholic acid, and deoxycholic acid by mild, modular olefin cross-metathesis reactions. ...
We introduce efficient conjugation of cholesterol (as a model steroid), lithocholic acid, and deoxycholic acid by mild, …
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