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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 2
1995 3
1996 3
1997 5
1998 8
1999 12
2000 27
2001 42
2002 87
2003 102
2004 137
2005 157
2006 178
2007 203
2008 235
2009 263
2010 276
2011 267
2012 295
2013 345
2014 311
2015 283
2016 281
2017 272
2018 271
2019 268
2020 217
2021 52
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4,006 results
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Page 1
Cholesterol Homeostasis and Liver X Receptor (LXR) in Atherosclerosis.
Guo S, Li L, Yin H. Guo S, et al. Cardiovasc Hematol Disord Drug Targets. 2018;18(1):27-33. doi: 10.2174/1871529X18666180302113713. Cardiovasc Hematol Disord Drug Targets. 2018. PMID: 29512473 Review.
Thus, it is critical to maintain cholesterol homeostasis including absorption, trafficking, biosynthesis, and efflux; dysregulation of cholesterol homeostasis may lead to human disorders such as atherosclerosis. As a cholesterol sensor, nuclear receptor liver X …
Thus, it is critical to maintain cholesterol homeostasis including absorption, trafficking, biosynthesis, and efflux; dysregulation of chole …
Nuclear receptors and nonalcoholic fatty liver disease.
Cave MC, Clair HB, Hardesty JE, Falkner KC, Feng W, Clark BJ, Sidey J, Shi H, Aqel BA, McClain CJ, Prough RA. Cave MC, et al. Biochim Biophys Acta. 2016 Sep;1859(9):1083-1099. doi: 10.1016/j.bbagrm.2016.03.002. Epub 2016 Mar 4. Biochim Biophys Acta. 2016. PMID: 26962021 Free PMC article. Review.
To support this function, following ligand-activation by xenobiotics, members of subfamily 1 nuclear receptors (NR1s) may heterodimerize with the retinoid X receptor (RXR) to regulate transcription of genes involved in energy and xenobiotic metabolism and inf …
To support this function, following ligand-activation by xenobiotics, members of subfamily 1 nuclear receptors (NR1s) may heterodimer …
Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche.
Bonnardel J, T'Jonck W, Gaublomme D, Browaeys R, Scott CL, Martens L, Vanneste B, De Prijck S, Nedospasov SA, Kremer A, Van Hamme E, Borghgraef P, Toussaint W, De Bleser P, Mannaerts I, Beschin A, van Grunsven LA, Lambrecht BN, Taghon T, Lippens S, Elewaut D, Saeys Y, Guilliams M. Bonnardel J, et al. Immunity. 2019 Oct 15;51(4):638-654.e9. doi: 10.1016/j.immuni.2019.08.017. Epub 2019 Sep 24. Immunity. 2019. PMID: 31561945 Free PMC article.
Engrafted circulating monocytes transmigrated into the perisinusoidal space and acquired the liver-associated transcription factors inhibitor of DNA 3 (ID3) and liver X receptor-alpha (LXR-alpha). ...This study shows that the Kupffer cell niche is comp …
Engrafted circulating monocytes transmigrated into the perisinusoidal space and acquired the liver-associated transcription factors i …
Liver X receptors in lipid signalling and membrane homeostasis.
Wang B, Tontonoz P. Wang B, et al. Nat Rev Endocrinol. 2018 Aug;14(8):452-463. doi: 10.1038/s41574-018-0037-x. Nat Rev Endocrinol. 2018. PMID: 29904174 Free PMC article. Review.
Liver X receptors alpha and beta (LXRalpha and LXRbeta) are nuclear receptors with pivotal roles in the transcriptional control of lipid metabolism. ...
Liver X receptors alpha and beta (LXRalpha and LXRbeta) are nuclear receptors with pivotal roles in the transcri …
LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer.
Tavazoie MF, Pollack I, Tanqueco R, Ostendorf BN, Reis BS, Gonsalves FC, Kurth I, Andreu-Agullo C, Derbyshire ML, Posada J, Takeda S, Tafreshian KN, Rowinsky E, Szarek M, Waltzman RJ, Mcmillan EA, Zhao C, Mita M, Mita A, Chmielowski B, Postow MA, Ribas A, Mucida D, Tavazoie SF. Tavazoie MF, et al. Cell. 2018 Feb 8;172(4):825-840.e18. doi: 10.1016/j.cell.2017.12.026. Epub 2018 Jan 11. Cell. 2018. PMID: 29336888 Free PMC article.
Through genetic and pharmacological approaches, we uncovered a pathway governing MDSC abundance in multiple cancer types. Therapeutic liver-X nuclear receptor (LXR) agonism reduced MDSC abundance in murine models and in patients treated in a first-in-human do …
Through genetic and pharmacological approaches, we uncovered a pathway governing MDSC abundance in multiple cancer types. Therapeutic liv …
MicroRNA 7 Impairs Insulin Signaling and Regulates Abeta Levels through Posttranscriptional Regulation of the Insulin Receptor Substrate 2, Insulin Receptor, Insulin-Degrading Enzyme, and Liver X Receptor Pathway.
Fernández-de Frutos M, Galán-Chilet I, Goedeke L, Kim B, Pardo-Marqués V, Pérez-García A, Herrero JI, Fernández-Hernando C, Kim J, Ramírez CM. Fernández-de Frutos M, et al. Mol Cell Biol. 2019 Oct 28;39(22):e00170-19. doi: 10.1128/MCB.00170-19. Print 2019 Nov 15. Mol Cell Biol. 2019. PMID: 31501273 Free PMC article.
Here, we show that microRNA 7 (miR-7), an abundant microRNA in the brain, targets insulin receptor (INSR), insulin receptor substrate 2 (IRS-2), and insulin-degrading enzyme (IDE), key regulators of insulin homeostatic functions in the central nervous system (CNS) a …
Here, we show that microRNA 7 (miR-7), an abundant microRNA in the brain, targets insulin receptor (INSR), insulin receptor su …
Kruppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility.
Li Z, Martin M, Zhang J, Huang HY, Bai L, Zhang J, Kang J, He M, Li J, Maurya MR, Gupta S, Zhou G, Sangwung P, Xu YJ, Lei T, Huang HD, Jain M, Jain MK, Subramaniam S, Shyy JY. Li Z, et al. Circulation. 2017 Oct 3;136(14):1315-1330. doi: 10.1161/CIRCULATIONAHA.117.027462. Epub 2017 Aug 9. Circulation. 2017. PMID: 28794002 Free PMC article.
BACKGROUND: Atherosclerosis is a multifaceted inflammatory disease involving cells in the vascular wall (eg, endothelial cells [ECs]), as well as circulating and resident immunogenic cells (eg, monocytes/macrophages). Acting as a ligand for liver X receptor ( …
BACKGROUND: Atherosclerosis is a multifaceted inflammatory disease involving cells in the vascular wall (eg, endothelial cells [ECs]), as we …
Liver X receptors link lipid metabolism and inflammation.
Schulman IG. Schulman IG. FEBS Lett. 2017 Oct;591(19):2978-2991. doi: 10.1002/1873-3468.12702. Epub 2017 Jun 13. FEBS Lett. 2017. PMID: 28555747 Free PMC article. Review.
Indeed, in many cases changes in metabolism appear to be necessary for a robust immune response. The Liver X receptors (LXRs) are members of the nuclear hormone receptor superfamily that regulate gene networks controlling cholesterol and lipid metaboli …
Indeed, in many cases changes in metabolism appear to be necessary for a robust immune response. The Liver X receptors …
Inflammation Triggers Liver X Receptor-Dependent Lipogenesis.
Liebergall SR, Angdisen J, Chan SH, Chang Y, Osborne TF, Koeppel AF, Turner SD, Schulman IG. Liebergall SR, et al. Mol Cell Biol. 2020 Jan 3;40(2):e00364-19. doi: 10.1128/MCB.00364-19. Print 2020 Jan 3. Mol Cell Biol. 2020. PMID: 31658997 Free PMC article.
The inflammation-dependent increase in lipogenesis requires the induction of the liver X receptors, members of the nuclear receptor superfamily of transcription factors, by type I interferons in response to inflammatory signals. Instead of the well-est …
The inflammation-dependent increase in lipogenesis requires the induction of the liver X receptors, members of the nucl …
Oxysterols in Autoimmunity.
Duc D, Vigne S, Pot C. Duc D, et al. Int J Mol Sci. 2019 Sep 12;20(18):4522. doi: 10.3390/ijms20184522. Int J Mol Sci. 2019. PMID: 31547302 Free PMC article. Review.
Studies from the last few decades have demonstrated that oxysterols are not only active metabolites but are further involved in the modulation of immune responses. Liver X Receptors (LXRs), nuclear receptors for oxysterols, are important for cholestero …
Studies from the last few decades have demonstrated that oxysterols are not only active metabolites but are further involved in the modulati …
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