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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1982 1
1983 1
1985 2
1986 3
1987 1
1988 4
1989 5
1990 6
1991 4
1992 5
1993 6
1994 2
1995 6
1996 5
1997 4
1998 5
1999 12
2000 8
2001 5
2002 7
2003 13
2004 24
2005 43
2006 30
2007 31
2008 41
2009 41
2010 53
2011 39
2012 64
2013 74
2014 72
2015 70
2016 95
2017 87
2018 100
2019 116
2020 99
2021 17
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1,062 results
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Page 1
Neutrophil extracellular traps - the dark side of neutrophils.
Sørensen OE, Borregaard N. Sørensen OE, et al. J Clin Invest. 2016 May 2;126(5):1612-20. doi: 10.1172/JCI84538. Epub 2016 May 2. J Clin Invest. 2016. PMID: 27135878 Free PMC article. Review.
NETs are formed during infection in vivo by mechanisms different from those originally described in vitro. Citrullination of histones by peptidyl arginine deiminase 4 (PAD4) is central for NET formation in vivo. NETs may spur formation of autoantibodies and may also …
NETs are formed during infection in vivo by mechanisms different from those originally described in vitro. Citrullination of histones by pep …
Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice.
Albrengues J, Shields MA, Ng D, Park CG, Ambrico A, Poindexter ME, Upadhyay P, Uyeminami DL, Pommier A, Küttner V, Bružas E, Maiorino L, Bautista C, Carmona EM, Gimotty PA, Fearon DT, Chang K, Lyons SK, Pinkerton KE, Trotman LC, Goldberg MS, Yeh JT, Egeblad M. Albrengues J, et al. Science. 2018 Sep 28;361(6409):eaao4227. doi: 10.1126/science.aao4227. Science. 2018. PMID: 30262472 Free PMC article.
Peptidylarginine deiminase-4 gene polymorphisms are associated with systemic lupus erythematosus and lupus nephritis.
Massarenti L, Enevold C, Damgaard D, Ødum N, Nielsen CH, Jacobsen S. Massarenti L, et al. Scand J Rheumatol. 2019 Mar;48(2):133-140. doi: 10.1080/03009742.2018.1488273. Epub 2018 Sep 30. Scand J Rheumatol. 2019. PMID: 30269634
OBJECTIVE: Peptidylarginine deiminase-4 (PAD4) is highly expressed by neutrophils and essential for citrullination occurring during the formation of neutrophil extracellular traps, which have been implicated in the pathogenesis of systemic lupus erythematosus (SLE) …
OBJECTIVE: Peptidylarginine deiminase-4 (PAD4) is highly expressed by neutrophils and essential for citrullination occurring d …
Inhibition of peptidylarginine deiminase alleviates LPS-induced pulmonary dysfunction and improves survival in a mouse model of lethal endotoxemia.
Liang Y, Pan B, Alam HB, Deng Q, Wang Y, Chen E, Liu B, Tian Y, Williams AM, Duan X, Wang Y, Zhang J, Li Y. Liang Y, et al. Eur J Pharmacol. 2018 Aug 15;833:432-440. doi: 10.1016/j.ejphar.2018.07.005. Epub 2018 Jul 5. Eur J Pharmacol. 2018. PMID: 29981294 Free PMC article.
Although the mechanisms by which infection induces NETosis and how that leads to organ dysfunction remain largely unknown, NET formation is often found following citrullination of histone H3 (CitH3) by peptidylarginine deiminase (PAD). We hypothesized that lipopolys …
Although the mechanisms by which infection induces NETosis and how that leads to organ dysfunction remain largely unknown, NET formation is …
[The pathogenic role of ACPA in rheumatoid arthritis].
Umeda N, Matsumoto I, Sumida T. Umeda N, et al. Nihon Rinsho Meneki Gakkai Kaishi. 2017;40(6):391-395. doi: 10.2177/jsci.40.391. Nihon Rinsho Meneki Gakkai Kaishi. 2017. PMID: 29367523 Free article. Review. Japanese.
In rheumatoid arthritis (RA), ACPA (anti-citrullinated protein/peptide antibody) is elevated with high specificity, and clinically, anti-CCP (cyclic citrullinated peptide) antibody is widely used for diagnosis of RA. ...These were showed immune complexes including ACPA or …
In rheumatoid arthritis (RA), ACPA (anti-citrullinated protein/peptide antibody) is elevated with high specificity, and clinically, a …
PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets.
Curran AM, Naik P, Giles JT, Darrah E. Curran AM, et al. Nat Rev Rheumatol. 2020 Jun;16(6):301-315. doi: 10.1038/s41584-020-0409-1. Epub 2020 Apr 27. Nat Rev Rheumatol. 2020. PMID: 32341463 Review.
Peptidylarginine deiminases (PADs) have an important role in the pathogenesis of rheumatoid arthritis (RA) owing to their ability to generate citrullinated proteins - the hallmark autoantigens of RA. ...
Peptidylarginine deiminases (PADs) have an important role in the pathogenesis of rheumatoid arthritis (RA) owing to their abil
Assessment of Peptidylarginine Deiminase Activity by ELISA Using Human Fibrinogen as Substrate.
Damgaard D, Nielsen CH. Damgaard D, et al. Methods Mol Biol. 2019;1901:239-242. doi: 10.1007/978-1-4939-8949-2_20. Methods Mol Biol. 2019. PMID: 30539583
An enzyme-linked immunosorbent assay (ELISA) for measurement of the activity of peptidylarginine deiminases (PADs), the enzymes responsible for citrullination, is described. ...
An enzyme-linked immunosorbent assay (ELISA) for measurement of the activity of peptidylarginine deiminases (PADs), the enzyme …
Peptidylarginine deiminase 4 (PAD4) activity in early rheumatoid arthritis.
Jonsson MK, Kantyka T, Falkowski K, Aliko A, Aga AB, Lillegraven S, Sexton J, Fevang BT, Mydel P, Haavardsholm EA. Jonsson MK, et al. Scand J Rheumatol. 2020 Mar;49(2):87-95. doi: 10.1080/03009742.2019.1641216. Epub 2019 Sep 23. Scand J Rheumatol. 2020. PMID: 31544586
Objectives: Peptidylarginine deiminases (PADs) are a family of calcium-dependent enzymes catalysing the conversion of arginine residues to citrulline, which may constitute a risk factor in rheumatoid arthritis (RA) pathogenesis. ...Changes in PAD(Act) levels …
Objectives: Peptidylarginine deiminases (PADs) are a family of calcium-dependent enzymes catalysing the conversion of argin
MiR-155 Regulates PAD4-Dependent Formation of Neutrophil Extracellular Traps.
Hawez A, Al-Haidari A, Madhi R, Rahman M, Thorlacius H. Hawez A, et al. Front Immunol. 2019 Nov 1;10:2462. doi: 10.3389/fimmu.2019.02462. eCollection 2019. Front Immunol. 2019. PMID: 31736940 Free PMC article.
Accumulating data suggest that neutrophil extracellular traps (NETs) exert a key function in several diseases. Peptidylarginine deiminase 4 (PAD4) regulates NET formation via citrullination of histones. ...
Accumulating data suggest that neutrophil extracellular traps (NETs) exert a key function in several diseases. Peptidylarginine de
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