Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1976 1
1977 1
1978 7
1979 5
1980 3
1981 4
1982 6
1983 6
1984 8
1985 2
1986 4
1987 10
1988 12
1989 6
1990 5
1991 4
1992 4
1993 1
1994 6
1995 3
1996 4
1997 4
1998 9
1999 12
2000 25
2001 42
2002 81
2003 95
2004 98
2005 143
2006 154
2007 141
2008 169
2009 158
2010 169
2011 182
2012 183
2013 209
2014 171
2015 156
2016 174
2017 161
2018 181
2019 163
2020 122
Text availability
Article attribute
Article type
Publication date

Search Results

2,711 results
Results by year
Filters applied: . Clear all
Page 1
Pregnane X receptor activation potentiates ritonavir hepatotoxicity.
Shehu AI, Lu J, Wang P, Zhu J, Wang Y, Yang D, McMahon D, Xie W, Gonzalez FJ, Ma X. Shehu AI, et al. J Clin Invest. 2019 Apr 30;129(7):2898-2903. doi: 10.1172/JCI128274. J Clin Invest. 2019. PMID: 31039134 Free PMC article.
Both rifampicin and efavirenz are activators of the pregnane X receptor (PXR), a transcription factor with significant inter-species differences in ligand-dependent activation. ...
Both rifampicin and efavirenz are activators of the pregnane X receptor (PXR), a transcription factor with significant …
[Role of pregnane X receptor (PXR) in endobiotic metabolism].
Luan ZL, Huo XX, Guan YF, Zhang XY. Luan ZL, et al. Sheng Li Xue Bao. 2019 Apr 25;71(2):311-318. Sheng Li Xue Bao. 2019. PMID: 31008491 Free article. Review. Chinese.
As a member of the nuclear receptor superfamily, the pregnane X receptor (PXR) is a ligand-activated transcription factor. PXR is highly expressed in liver and intestinal tissues, and also found in other tissues and organs, such as stomach and kidney. …
As a member of the nuclear receptor superfamily, the pregnane X receptor (PXR) is a ligand-activated transcripti …
Pregnane X Receptor Regulates Liver Size and Liver Cell Fate by Yes-Associated Protein Activation in Mice.
Jiang Y, Feng D, Ma X, Fan S, Gao Y, Fu K, Wang Y, Sun J, Yao X, Liu C, Zhang H, Xu L, Liu A, Gonzalez FJ, Yang Y, Gao B, Huang M, Bi H. Jiang Y, et al. Hepatology. 2019 Jan;69(1):343-358. doi: 10.1002/hep.30131. Epub 2018 Dec 17. Hepatology. 2019. PMID: 30048004 Free PMC article.
Activation of pregnane X receptor (PXR), a nuclear receptor that controls xenobiotic and endobiotic metabolism, is known to induce liver enlargement, but the molecular signals and cell types responding to PXR-induced hepatomegaly remain unknown. ...
Activation of pregnane X receptor (PXR), a nuclear receptor that controls xenobiotic and endobiotic metabolism, …
Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock-Induced Liver Injury.
Xie Y, Xu M, Deng M, Li Z, Wang P, Ren S, Guo Y, Ma X, Fan J, Billiar TR, Xie W. Xie Y, et al. Hepatology. 2019 Sep;70(3):995-1010. doi: 10.1002/hep.30691. Epub 2019 Jun 24. Hepatology. 2019. PMID: 31038762 Free PMC article.
Pregnane X receptor (PXR) is a species-specific xenobiotic receptor that regulates the expression of drug-metabolizing enzymes (DMEs) such as the cytochrome P450 (CYP) 3A. ...
Pregnane X receptor (PXR) is a species-specific xenobiotic receptor that regulates the expression of drug-metabo
Constitutive androstane receptor and pregnane X receptor cooperatively ameliorate DSS-induced colitis.
Uehara D, Tojima H, Kakizaki S, Yamazaki Y, Horiguchi N, Takizawa D, Sato K, Yamada M, Uraoka T. Uehara D, et al. Dig Liver Dis. 2019 Feb;51(2):226-235. doi: 10.1016/j.dld.2018.10.008. Epub 2018 Oct 22. Dig Liver Dis. 2019. PMID: 30442521
BACKGROUND: Nuclear receptor pregnane X receptor (PXR) was shown to be protective in case of dextran sulfate sodium (DSS)-induced colitis. Constitutive androstane receptor (CAR) belongs to the same nuclear receptor subfamily with PXR. The …
BACKGROUND: Nuclear receptor pregnane X receptor (PXR) was shown to be protective in case of dextran sulfate sod …
Marine Ligands of the Pregnane X Receptor (PXR): An Overview.
Carazo A, Mladěnka P, Pávek P. Carazo A, et al. Mar Drugs. 2019 Sep 28;17(10):554. doi: 10.3390/md17100554. Mar Drugs. 2019. PMID: 31569349 Free PMC article. Review.
Pregnane X Receptor (PXR) is a ligand-activated transcription factor which binds many structurally different molecules. The receptor is able to regulate the expression of a wide array of genes and is involved in cancer and different key physiological p
Pregnane X Receptor (PXR) is a ligand-activated transcription factor which binds many structurally different molecules.
The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation.
Pulakazhi Venu VK, Saifeddine M, Mihara K, Tsai YC, Nieves K, Alston L, Mani S, McCoy KD, Hollenberg MD, Hirota SA. Pulakazhi Venu VK, et al. Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E350-E361. doi: 10.1152/ajpendo.00572.2018. Epub 2019 Jun 18. Am J Physiol Endocrinol Metab. 2019. PMID: 31211619 Free PMC article.
One such metabolite, indole 3-propionic acid (IPA), can activate the pregnane X receptor(PXR), a xenobiotic-activated nuclear receptor present in many tissues, including the vascular endothelium. ...Endothelium-dependent, nitric oxide(NO)-mediated musc …
One such metabolite, indole 3-propionic acid (IPA), can activate the pregnane X receptor(PXR), a xenobiotic-activated n …
CITCO Directly Binds to and Activates Human Pregnane X Receptor.
Lin W, Bwayi M, Wu J, Li Y, Chai SC, Huber AD, Chen T. Lin W, et al. Mol Pharmacol. 2020 Mar;97(3):180-190. doi: 10.1124/mol.119.118513. Epub 2019 Dec 27. Mol Pharmacol. 2020. PMID: 31882411 Free PMC article.
The xenobiotic receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are activated by structurally diverse chemicals to regulate the expression of target genes, and they have overlapping regulation in terms of ligands and targe …
The xenobiotic receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are activated by s …
PXR: More Than Just a Master Xenobiotic Receptor.
Oladimeji PO, Chen T. Oladimeji PO, et al. Mol Pharmacol. 2018 Feb;93(2):119-127. doi: 10.1124/mol.117.110155. Epub 2017 Nov 7. Mol Pharmacol. 2018. PMID: 29113993 Free PMC article. Review.
Pregnane X receptor (PXR) is a nuclear receptor considered to be a master xenobiotic receptor that coordinately regulates the expression of genes encoding drug-metabolizing enzymes and drug transporters to essentially detoxify and eliminate xeno
Pregnane X receptor (PXR) is a nuclear receptor considered to be a master xenobiotic receptor that coordi
Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium-induced colitis in mice.
Liu M, Zhang G, Zheng C, Song M, Liu F, Huang X, Bai S, Huang X, Lin C, Zhu C, Hu Y, Mi S, Liu C. Liu M, et al. Br J Pharmacol. 2018 Sep;175(17):3563-3580. doi: 10.1111/bph.14424. Epub 2018 Jul 23. Br J Pharmacol. 2018. PMID: 29945292 Free PMC article.
BACKGROUND AND PURPOSE: Activation of the human pregnane X receptor (PXR; NR1I2) has potential therapeutic uses for inflammatory bowel disease (IBD). ...KEY RESULTS: IMP activated CYP3A4 promoter activity, recruited steroid receptor coactivator 1 to th …
BACKGROUND AND PURPOSE: Activation of the human pregnane X receptor (PXR; NR1I2) has potential therapeutic uses for inf …
2,711 results
Jump to page
Feedback