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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 2
2007 22
2008 42
2009 76
2010 46
2011 52
2012 51
2013 64
2014 64
2015 65
2016 65
2017 59
2018 50
2019 64
2020 56
2021 10
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684 results
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All-trans Retinoic Acid Regulates the Balance of Treg-Th17 Cells through ERK and P38 Signaling Pathway.
Wu S, Wang W, Le Q. Wu S, et al. Iran J Immunol. 2019 Mar;16(1):1-10. doi: 10.22034/IJI.2019.39402. Iran J Immunol. 2019. PMID: 30864551 Free article.
BACKGROUND: All-trans retinoic acid (ATRA) potentiates TGF-beta-dependent regulatory T cells (Treg) induction, while it inhibits pro-inflammatory interleukin-17-producing T helper cells (Th17) differentiation. Combined application of ATRA and TG …
BACKGROUND: All-trans retinoic acid (ATRA) potentiates TGF-beta-dependent regulatory T cells (Treg) induction, while it …
HIF1α and metabolic reprogramming in inflammation.
Corcoran SE, O'Neill LA. Corcoran SE, et al. J Clin Invest. 2016 Oct 3;126(10):3699-3707. doi: 10.1172/JCI84431. Epub 2016 Aug 29. J Clin Invest. 2016. PMID: 27571407 Free PMC article. Review.
Additionally, HIF1alpha is critical for the maturation of dendritic cells and for the activation of T cells. HIF1alpha is induced in LPS-activated macrophages, where it is critically involved in glycolysis and the induction of proinflammatory genes, notably Il1b. .. …
Additionally, HIF1alpha is critical for the maturation of dendritic cells and for the activation of T cells. HIF1alpha is indu …
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid.
Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, Cheroutre H. Mucida D, et al. Science. 2007 Jul 13;317(5835):256-60. doi: 10.1126/science.1145697. Epub 2007 Jun 14. Science. 2007. PMID: 17569825 Free article.
The cytokine transforming growth factor-beta (TGF-beta) converts naive T cells into regulatory T (Treg) cells that prevent autoimmunity. However, in the presence of interleukin-6 (IL-6), TGF-beta has also been found to promote the differentiation of naive T lymphocy …
The cytokine transforming growth factor-beta (TGF-beta) converts naive T cells into regulatory T (Treg) cells that prevent aut …
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring.
Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV, Hoeffer CA, Littman DR, Huh JR. Choi GB, et al. Science. 2016 Feb 26;351(6276):933-9. doi: 10.1126/science.aad0314. Epub 2016 Jan 28. Science. 2016. PMID: 26822608 Free PMC article.
Using both genetic mutants and blocking antibodies in mice, we show that retinoic acid receptor-related orphan nuclear receptor gamma t (RORgammat)-dependent effector T lymphocytes [for example, T helper 17 (TH17) cells] and the effector cytokine inter …
Using both genetic mutants and blocking antibodies in mice, we show that retinoic acid receptor-related orphan nuclear recepto …
A role for Th1-like Th17 cells in the pathogenesis of inflammatory and autoimmune disorders.
Kamali AN, Noorbakhsh SM, Hamedifar H, Jadidi-Niaragh F, Yazdani R, Bautista JM, Azizi G. Kamali AN, et al. Mol Immunol. 2019 Jan;105:107-115. doi: 10.1016/j.molimm.2018.11.015. Epub 2018 Nov 28. Mol Immunol. 2019. PMID: 30502718 Review.
The T helper 17 (Th17) cells contain a dynamic subset of CD4+ T-cells that are able to develop into other different lineage subsets, including the Th1-like Th17 cells. ...Here, the actual mechanisms for Th17 cells plasticity to Th1 …
The T helper 17 (Th17) cells contain a dynamic subset of CD4+ T-cells that are able to develop into other different lin …
Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations.
Guntermann C, Piaia A, Hamel ML, Theil D, Rubic-Schneider T, Del Rio-Espinola A, Dong L, Billich A, Kaupmann K, Dawson J, Hoegenauer K, Orain D, Hintermann S, Stringer R, Patel DD, Doelemeyer A, Deurinck M, Schümann J. Guntermann C, et al. JCI Insight. 2017 Mar 9;2(5):e91127. doi: 10.1172/jci.insight.91127. JCI Insight. 2017. PMID: 28289717 Free PMC article.
Retinoic-acid-orphan-receptor-C (RORC) is a master regulator of Th17 cells, which are pathogenic in several autoimmune diseases. ...We sought to determine whether pharmacological RORC inhibition could be an effective and safe therapy for autoimmune dis
Retinoic-acid-orphan-receptor-C (RORC) is a master regulator of Th17 cells, which are pathogenic in several auto
A cellular and molecular view of T helper 17 cell plasticity in autoimmunity.
Stadhouders R, Lubberts E, Hendriks RW. Stadhouders R, et al. J Autoimmun. 2018 Feb;87:1-15. doi: 10.1016/j.jaut.2017.12.007. Epub 2017 Dec 22. J Autoimmun. 2018. PMID: 29275836 Free article. Review.
The observed plasticity of Th17 cells towards the Th1 phenotype can be explained by extensive epigenetic priming of the IFNG locus in Th17 cells. In fact, Th17 cells display an IFNG chromatin landscape that is remarkably similar to that o …
The observed plasticity of Th17 cells towards the Th1 phenotype can be explained by extensive epigenetic priming of the IFNG l …
The 3 major types of innate and adaptive cell-mediated effector immunity.
Annunziato F, Romagnani C, Romagnani S. Annunziato F, et al. J Allergy Clin Immunol. 2015 Mar;135(3):626-35. doi: 10.1016/j.jaci.2014.11.001. Epub 2014 Dec 18. J Allergy Clin Immunol. 2015. PMID: 25528359 Review.
Type 1 immunity consists of T-bet(+) IFN-gamma-producing group 1 ILCs (ILC1 and natural killer cells), CD8(+) cytotoxic T cells (TC1), and CD4(+) TH1 cells, which protect against intracellular microbes through activation of mononuclear phagocytes. ...Type 3 i …
Type 1 immunity consists of T-bet(+) IFN-gamma-producing group 1 ILCs (ILC1 and natural killer cells), CD8(+) cytotoxic T cells
Potential role of melatonin in autoimmune diseases.
Zhao CN, Wang P, Mao YM, Dan YL, Wu Q, Li XM, Wang DG, Davis C, Hu W, Pan HF. Zhao CN, et al. Cytokine Growth Factor Rev. 2019 Aug;48:1-10. doi: 10.1016/j.cytogfr.2019.07.002. Epub 2019 Jul 16. Cytokine Growth Factor Rev. 2019. PMID: 31345729 Review.
Pathogenic Th1 and Th17 cells can secrete signature proinflammatory cytokines, including interferon (IFN)-gamma and IL-17, however Tregs can suppress effector cells and dampen a wide spectrum of immune responses. ...Treatment with MLT directly interferes with …
Pathogenic Th1 and Th17 cells can secrete signature proinflammatory cytokines, including interferon (IFN)-gamma and IL-17, how …
Interleukin-17-producing gammadelta T (gammadelta17) cells in inflammatory diseases.
Akitsu A, Iwakura Y. Akitsu A, et al. Immunology. 2018 Dec;155(4):418-426. doi: 10.1111/imm.12993. Epub 2018 Sep 10. Immunology. 2018. PMID: 30133701 Free PMC article. Review.
Recent studies have revealed that IL-17-producing gammadelta T cells (gammadelta17 cells) in addition to IL-17-producing CD4(+) T cells [T helper type 17 (Th17) cells] are often the main producers of IL-17 in mouse models of inflammatory disease …
Recent studies have revealed that IL-17-producing gammadelta T cells (gammadelta17 cells) in addition to IL-17-producing CD4(+ …
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