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Year Number of Results
1995 2
1996 2
1997 1
2004 2
2006 1
2007 3
2008 4
2009 5
2010 5
2011 3
2012 2
2013 4
2016 3
2017 2
2018 1
2019 2
2020 0
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Intestinal Dendritic Cells in Health and Gut Inflammation.
Stagg AJ. Stagg AJ. Front Immunol. 2018 Dec 6;9:2883. doi: 10.3389/fimmu.2018.02883. eCollection 2018. Front Immunol. 2018. PMID: 30574151 Free PMC article. Review.
These properties include the ability to produce all-trans retinoic acid (RA) and imprint gut tropism on T cells they activate. ...
These properties include the ability to produce all-trans retinoic acid (RA) and imprint gut tropism on T cells they activate. …
Retinoic acid imprints gut-homing specificity on T cells.
Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song SY. Iwata M, et al. Immunity. 2004 Oct;21(4):527-38. doi: 10.1016/j.immuni.2004.08.011. Immunity. 2004. PMID: 15485630 Free article.
Dendritic cells from the gut-associated lymphoid organs produced retinoic acid from retinol. The enhanced alpha4beta7 expression on T cells by antigenic stimulation with these dendritic cells was suppressed by the retinal dehydrogenase inhibitor citral and the re
Dendritic cells from the gut-associated lymphoid organs produced retinoic acid from retinol. The enhanced alpha4beta7 expressi …
Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells.
Eksteen B, Mora JR, Haughton EL, Henderson NC, Lee-Turner L, Villablanca EJ, Curbishley SM, Aspinall AI, von Andrian UH, Adams DH. Eksteen B, et al. Gastroenterology. 2009 Jul;137(1):320-9. doi: 10.1053/j.gastro.2009.02.046. Epub 2009 Feb 21. Gastroenterology. 2009. PMID: 19233184 Free PMC article.
In mice, imprinting of CCR9 and alpha4beta7 is dependent on retinoic acid during T-cell activation. Tissue specificity is lost in primary sclerosing cholangitis (PSC), an extraintestinal manifestation of inflammatory bowel disease, when ectopic expression of mucosal …
In mice, imprinting of CCR9 and alpha4beta7 is dependent on retinoic acid during T-cell activation. Tissue specificity is lost …
GPR15-mediated homing controls immune homeostasis in the large intestine mucosa.
Kim SV, Xiang WV, Kwak C, Yang Y, Lin XW, Ota M, Sarpel U, Rifkin DB, Xu R, Littman DR. Kim SV, et al. Science. 2013 Jun 21;340(6139):1456-9. doi: 10.1126/science.1237013. Epub 2013 May 9. Science. 2013. PMID: 23661644 Free PMC article.
Lymphocyte homing, which contributes to inflammation, has been studied extensively in the small intestine, but there is little known about homing to the large intestine, the site most commonly affected in inflammatory bowel disease. ...GPR15 expression was mo
Lymphocyte homing, which contributes to inflammation, has been studied extensively in the small intestine, but there is little
Role of beta7 integrins in intestinal lymphocyte homing and retention.
Gorfu G, Rivera-Nieves J, Ley K. Gorfu G, et al. Curr Mol Med. 2009 Sep;9(7):836-50. doi: 10.2174/156652409789105525. Curr Mol Med. 2009. PMID: 19860663 Free PMC article. Review.
Mucosal dendritic cells (DCs) regulate the expression of the gut homing receptors alpha(4)beta(7) integrin and the chemokine receptor CCR9 on activated effector and regulatory lymphocytes in a retinoic acid-dependent manner. ...Here, we review the current und …
Mucosal dendritic cells (DCs) regulate the expression of the gut homing receptors alpha(4)beta(7) integrin and the chemokine receptor …
Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration.
Aoyama K, Saha A, Tolar J, Riddle MJ, Veenstra RG, Taylor PA, Blomhoff R, Panoskaltsis-Mortari A, Klebanoff CA, Socié G, Munn DH, Murphy WJ, Serody JS, Fulton LM, Teshima T, Chandraratna RA, Dmitrovsky E, Guo Y, Noelle RJ, Blazar BR. Aoyama K, et al. Blood. 2013 Sep 19;122(12):2125-34. doi: 10.1182/blood-2012-11-470252. Epub 2013 Jun 27. Blood. 2013. PMID: 23814022 Free PMC article.
Vitamin A metabolism within the intestine produces retinoic acid, which contributes to intestinal homeostasis and tolerance induction. ...Moreover, transgenic donor T cells expressing a retinoic acid receptor (RAR) response element luciferase reporter …
Vitamin A metabolism within the intestine produces retinoic acid, which contributes to intestinal homeostasis and tolerance in …
Retinoic acid induces aggregation of the acute promyelocytic leukemia cell line NB-4 by utilization of LFA-1 and ICAM-2.
Larson RS, Brown DC, Sklar LA. Larson RS, et al. Blood. 1997 Oct 1;90(7):2747-56. Blood. 1997. PMID: 9326242
All-trans retinoic acid (tRA) is a potent differentiation agent that is effective therapy for acute promyelocytic leukemia (APL). ...Taken together, our findings provide a clinically relevant system for study of LFA-1/ICAM-2 interaction and suggest a mechanism in pa …
All-trans retinoic acid (tRA) is a potent differentiation agent that is effective therapy for acute promyelocytic leukemia (AP …
In Vivo Generation of Gut-Homing Regulatory T Cells for the Suppression of Colitis.
Xu Y, Cheng Y, Baylink DJ, Wasnik S, Goel G, Huang M, Cao H, Qin X, Lau KW, Chan C, Koch A, Pham LH, Zhang J, Li CH, Wang X, Berumen EC, Smith J, Tang X. Xu Y, et al. J Immunol. 2019 Jun 15;202(12):3447-3457. doi: 10.4049/jimmunol.1800018. Epub 2019 May 3. J Immunol. 2019. PMID: 31053627 Free article.
We showed that dendritic cells (DCs), engineered to de novo produce high concentrations of both 1,25-dihydroxyvitamin D, the active vitamin D metabolite, and retinoic acid, an active vitamin A metabolite, augmented the induction of T cells that express both the regu …
We showed that dendritic cells (DCs), engineered to de novo produce high concentrations of both 1,25-dihydroxyvitamin D, the active vitamin …
Exosomal regulation of lymphocyte homing to the gut.
Park EJ, Prajuabjinda O, Soe ZY, Darkwah S, Appiah MG, Kawamoto E, Momose F, Shiku H, Shimaoka M. Park EJ, et al. Blood Adv. 2019 Jan 8;3(1):1-11. doi: 10.1182/bloodadvances.2018024877. Blood Adv. 2019. PMID: 30591532 Free PMC article.
Here, we study the roles of T exosomes in the regulation of gut-specific T-cell homing. The gut-tropic T cells induced by retinoic acid secrete the exosomes that upregulate integrin α4β7 binding to the MAdCAM-1 expressed on high endothelial venules in the gut …
Here, we study the roles of T exosomes in the regulation of gut-specific T-cell homing. The gut-tropic T cells induced by retinoic
Transforming growth factor-beta and all-trans retinoic acid generate ex vivo transgenic regulatory T cells with intestinal homing receptors.
Moore C, Sauma D, Morales J, Bono MR, Rosemblatt M, Fierro JA. Moore C, et al. Transplant Proc. 2009 Jul-Aug;41(6):2670-2. doi: 10.1016/j.transproceed.2009.06.130. Transplant Proc. 2009. PMID: 19715998
In the gut, a subset of dendritic cells is specialized to induce Treg in a transforming growth factor-beta (TGF-beta)- and retinoic acid (RA)-dependent manner. ...Also, supplementation of the cultures with RA induced the expression of the intestinal homing re …
In the gut, a subset of dendritic cells is specialized to induce Treg in a transforming growth factor-beta (TGF-beta)- and retinoic
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