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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
2000 1
2002 4
2003 2
2004 2
2005 4
2006 1
2007 3
2008 1
2009 3
2010 3
2011 3
2012 1
2013 5
2014 4
2015 4
2016 1
2017 1
2018 4
2019 2
2020 0
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Page 1
Role of farnesoid X receptor and bile acids in alcoholic liver disease.
Manley S, Ding W. Manley S, et al. Acta Pharm Sin B. 2015 Mar;5(2):158-67. doi: 10.1016/j.apsb.2014.12.011. Epub 2015 Mar 9. Acta Pharm Sin B. 2015. PMID: 26579442 Free PMC article. Review.
Moreover, ALD may also associate with cholestasis. Emerging evidence now suggests that farnesoid X receptor (FXR) and bile acids also play important roles in ALD. ...Moreover, we summarize the findings on FXR, FoxO3a (forkhead box-containing protein class O3a …
Moreover, ALD may also associate with cholestasis. Emerging evidence now suggests that farnesoid X receptor (FXR) and b …
New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond.
Beuers U, Trauner M, Jansen P, Poupon R. Beuers U, et al. J Hepatol. 2015 Apr;62(1 Suppl):S25-37. doi: 10.1016/j.jhep.2015.02.023. J Hepatol. 2015. PMID: 25920087 Free article. Review.
These include nuclear and membrane receptor agonists and BA derivatives. The nuclear receptors farnesoid X receptor (FXR), retinoid X receptor (RXR), peroxisome proliferator-activated receptor α (PPARα), and pregnane X
These include nuclear and membrane receptor agonists and BA derivatives. The nuclear receptors farnesoid X receptor
Farnesoid x receptor in human metabolism and disease: the interplay between gene polymorphisms, clinical phenotypes and disease susceptibility.
Koutsounas I, Theocharis S, Delladetsima I, Patsouris E, Giaginis C. Koutsounas I, et al. Expert Opin Drug Metab Toxicol. 2015 Apr;11(4):523-32. doi: 10.1517/17425255.2014.999664. Epub 2015 Jan 2. Expert Opin Drug Metab Toxicol. 2015. PMID: 25553772 Review.
INTRODUCTION: Farnesoid x receptor (FXR) belongs to the group of nuclear receptors (NRs), which regulate the expression of various genes by binding to DNA either as a monomer or a heterodimer with retinoid x receptor. ...FXR single-nucleo …
INTRODUCTION: Farnesoid x receptor (FXR) belongs to the group of nuclear receptors (NRs), which regulate the expression …
Mechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis.
Gyamfi MA, Wan YJ. Gyamfi MA, et al. J Biol Chem. 2009 Apr 3;284(14):9321-30. doi: 10.1074/jbc.M808861200. Epub 2009 Jan 27. J Biol Chem. 2009. PMID: 19176532 Free PMC article.
Peroxisome proliferators, such as the lipid-lowering fibrates that function as agonists for peroxisome proliferator-activated receptor alpha (PPARalpha), induce liver tumors in rodents and may produce cholestasis in humans. ...Moreover, the mechanisms by which fibra …
Peroxisome proliferators, such as the lipid-lowering fibrates that function as agonists for peroxisome proliferator-activated receptor
Role of retinoid-X receptor-alpha in the suppression of rat bile acid coenzyme A-amino acid N-acyltransferase in liver during sepsis.
Chen YH, Hong IC, Kuo KK, Hsu HK, Hsu C. Chen YH, et al. Shock. 2007 Jul;28(1):65-70. doi: 10.1097/shk.0b013e31802ec5d2. Shock. 2007. PMID: 17483744
Sepsis causes intrahepatic cholestasis and leads to hepatic failure. However, the pathophysiology of hepatic events is unclear. Expression of rat hepatic bile acid coenzyme A-amino acid N-acyltransferase (rBAT), a major enzyme for the conjugation of bile acids, is signific …
Sepsis causes intrahepatic cholestasis and leads to hepatic failure. However, the pathophysiology of hepatic events is unclear. Expre …
NFKB1 and MANBA Confer Disease Susceptibility to Primary Biliary Cholangitis via Independent Putative Primary Functional Variants.
Hitomi Y, Nakatani K, Kojima K, Nishida N, Kawai Y, Kawashima M, Aiba Y, Nagasaki M, Nakamura M, Tokunaga K. Hitomi Y, et al. Cell Mol Gastroenterol Hepatol. 2019;7(3):515-532. doi: 10.1016/j.jcmgh.2018.11.006. Epub 2018 Dec 4. Cell Mol Gastroenterol Hepatol. 2019. PMID: 30528300 Free PMC article.
RESULTS: Among the SNPs in the NFKB1/MANBA region, rs17032850 and rs227361, which changed the binding of transcription factors lymphoid enhancer-binding factor 1 (LEF-1) and retinoid X receptor α (RXRα), respectively, were identified as putative primary funct …
RESULTS: Among the SNPs in the NFKB1/MANBA region, rs17032850 and rs227361, which changed the binding of transcription factors lymphoid enha …
Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump.
Plass JR, Mol O, Heegsma J, Geuken M, Faber KN, Jansen PL, Müller M. Plass JR, et al. Hepatology. 2002 Mar;35(3):589-96. doi: 10.1053/jhep.2002.31724. Hepatology. 2002. PMID: 11870371
Sequence analysis for possible regulatory elements showed a farnesoid X receptor responsive element (FXRE) at position minus sign180. The farnesoid X receptor (FXR) functions as a heterodimer with the retinoid X receptor alpha (RXR …
Sequence analysis for possible regulatory elements showed a farnesoid X receptor responsive element (FXRE) at position minus s …
Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures.
Han H, Xu L, Xiong K, Zhang T, Wang Z. Han H, et al. Cell Physiol Biochem. 2018;49(4):1304-1319. doi: 10.1159/000493409. Epub 2018 Sep 17. Cell Physiol Biochem. 2018. PMID: 30223280 Free article.
RESULTS: Integrated analyses of proteomic and metabonomic studies showed altered pathways in cholestasis-induced liver injury involving increased activity of farnesoid X receptor/retinoid X receptor, bile acid biosynthesis, and peroxisome …
RESULTS: Integrated analyses of proteomic and metabonomic studies showed altered pathways in cholestasis-induced liver injury involvi …
Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis.
Geier A, Dietrich CG, Voigt S, Kim SK, Gerloff T, Kullak-Ublick GA, Lorenzen J, Matern S, Gartung C. Geier A, et al. Hepatology. 2003 Aug;38(2):345-54. doi: 10.1053/jhep.2003.50317. Hepatology. 2003. PMID: 12883478
However, inactivation of either cytokine led to preservation of HNF1 and partially of retinoid X receptor/retinoic acid receptor (RXR/RAR) binding activity. No effect of anticytokines was seen on pregnane X receptor (PXR) and constitutive …
However, inactivation of either cytokine led to preservation of HNF1 and partially of retinoid X receptor/retinoic acid …
On the Role of Illness Duration and Nutrient Restriction in Cholestatic Alterations that Occur During Critical Illness.
Jenniskens M, Güiza F, Oorts M, Vander Perre S, Derde S, Dufour T, Thiessen S, Annaert P, Van den Berghe G, Langouche L. Jenniskens M, et al. Shock. 2018 Aug;50(2):187-198. doi: 10.1097/SHK.0000000000001001. Shock. 2018. PMID: 29076974 Free PMC article.
BACKGROUND AND AIMS: Elevated markers of cholestasis are common in response to critical illness, and associated with adverse outcome. ...From 30 h onward, nuclear farnesoid-X-receptor-retinoid-X-receptor staining was significantly suppres …
BACKGROUND AND AIMS: Elevated markers of cholestasis are common in response to critical illness, and associated with adverse outcome. …
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