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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1997 1
1999 3
2000 2
2001 5
2002 3
2003 5
2004 2
2005 3
2006 4
2007 4
2008 5
2009 3
2010 5
2011 4
2012 6
2013 7
2014 1
2015 3
2016 4
2017 5
2019 3
2020 1
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73 results
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Farnesoid X receptor represses matrix metalloproteinase 7 expression, revealing this regulatory axis as a promising therapeutic target in colon cancer.
Peng Z, Chen J, Drachenberg CB, Raufman JP, Xie G. Peng Z, et al. J Biol Chem. 2019 May 24;294(21):8529-8542. doi: 10.1074/jbc.RA118.004361. Epub 2019 Apr 9. J Biol Chem. 2019. PMID: 30967475 Free PMC article.
The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of bile acid-activated transcription factors and an important regulator of cell proliferation, apoptosis, and Wnt signaling. ...FXR-mediated regulation of MMP7 transcription did no …
The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of bile acid-activated transcription fac …
Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells.
Ruan H, Zhan YY, Hou J, Xu B, Chen B, Tian Y, Wu D, Zhao Y, Zhang Y, Chen X, Mi P, Zhang L, Zhang S, Wang X, Cao H, Zhang W, Wang H, Li H, Su Y, Zhang XK, Hu T. Ruan H, et al. Oncogene. 2017 Dec 14;36(50):6906-6918. doi: 10.1038/onc.2017.296. Epub 2017 Aug 28. Oncogene. 2017. PMID: 28846104 Free PMC article.
Here, we provide evidence that berberine inhibits β-catenin function via directly binding to a unique region comprising residues Gln275, Arg316 and Arg371 in nuclear receptor retinoid X receptor alpha (RXRα), where berberine concomitantly binding to an …
Here, we provide evidence that berberine inhibits β-catenin function via directly binding to a unique region comprising residues Gln275, Arg …
Liver X receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRβ subcellular localization.
Courtaut F, Derangère V, Chevriaux A, Ladoire S, Cotte AK, Arnould L, Boidot R, Rialland M, Ghiringhelli F, Rébé C. Courtaut F, et al. Oncotarget. 2015 Sep 29;6(29):26651-62. doi: 10.18632/oncotarget.5791. Oncotarget. 2015. PMID: 26450852 Free PMC article.
Increasing evidence indicates that Liver X Receptors (LXRs) have some anticancer properties. We recently demonstrated that LXR ligands induce colon cancer cell pyroptosis through an LXRβ-dependent pathway. In the present study, we showed that human …
Increasing evidence indicates that Liver X Receptors (LXRs) have some anticancer properties. We recently demonstrated that LXR …
Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells.
Basseville A, Preisser L, de Carné Trécesson S, Boisdron-Celle M, Gamelin E, Coqueret O, Morel A. Basseville A, et al. Mol Cancer. 2011 Jul 6;10:80. doi: 10.1186/1476-4598-10-80. Mol Cancer. 2011. PMID: 21733184 Free PMC article.
Following drug treatments, SXR is activated and interacts with the retinoid X receptor (RXR) to induce expression of some genes involved in drug metabolism such as phase I enzyme (like CYP), phase II enzymes (like UGT) and transporters (e.g. ...CONCLUSIONS: A …
Following drug treatments, SXR is activated and interacts with the retinoid X receptor (RXR) to induce expression of so …
Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling.
Ye X, Wu H, Sheng L, Liu YX, Ye F, Wang M, Zhou H, Su Y, Zhang XK. Ye X, et al. Nat Commun. 2019 Apr 1;10(1):1463. doi: 10.1038/s41467-019-09375-8. Nat Commun. 2019. PMID: 30931933 Free PMC article.
Retinoid X receptor-alpha (RXRα) is a potent regulator of inflammatory responses; however, its therapeutic potential for inflammatory cancer remains to be explored. ...Here, we show that transgenic expression of tRXRα in mice accelerates the developmen
Retinoid X receptor-alpha (RXRα) is a potent regulator of inflammatory responses; however, its therapeutic potential fo
Vitamin D receptor and retinoid X receptor α status and vitamin D insufficiency in models of murine colitis.
Knackstedt RW, Moseley VR, Sun S, Wargovich MJ. Knackstedt RW, et al. Cancer Prev Res (Phila). 2013 Jun;6(6):585-93. doi: 10.1158/1940-6207.CAPR-12-0488. Epub 2013 Apr 12. Cancer Prev Res (Phila). 2013. PMID: 23585425 Free PMC article.
The anti-inflammatory actions of vitamin D have long been recognized and its importance in modulating colon cancer and colitis development is becoming apparent. ...To signal, VDR must heterodimerize with retinoid X receptor α (RXRα). If either V …
The anti-inflammatory actions of vitamin D have long been recognized and its importance in modulating colon cancer and colitis …
Decreased Expression of Retinoid X Receptors During Human and Azoxymethane-induced Colorectal Carcinogenesis in the Rat.
Hao X, Xiao H, Ju J, Hewitt SM, Morse HC 3rd. Hao X, et al. Anticancer Res. 2016 Jun;36(6):2659-64. Anticancer Res. 2016. PMID: 27272774
BACKGROUND/AIM: The family of retinoid X receptors (RXRs) including RXRα, β and γ, is involved in regulating cell proliferation, differentiation, apoptosis and development. ...
BACKGROUND/AIM: The family of retinoid X receptors (RXRs) including RXRα, β and γ, is involved in regulating cell proli …
Pregnane X receptor and human malignancy.
Koutsounas I, Patsouris E, Theocharis S. Koutsounas I, et al. Histol Histopathol. 2013 Apr;28(4):405-20. doi: 10.14670/HH-28.405. Epub 2013 Feb 15. Histol Histopathol. 2013. PMID: 23413096 Review.
Pregnane X Receptor (PXR) is a member of the nuclear receptor superfamily, expressed in liver, intestine and other tissues. PXR exerts transcriptional regulation by binding to its DNA response elements as an heterodimer with Retinoid X Recept
Pregnane X Receptor (PXR) is a member of the nuclear receptor superfamily, expressed in liver, intestine and other tiss …
Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family Registry.
Jacobs ET, Martínez ME, Campbell PT, Conti DV, Duggan D, Figueiredo JC, Haile RW, LeRoy EC, Poynter JN, Thompson PA, Baron JA. Jacobs ET, et al. Carcinogenesis. 2010 Aug;31(8):1412-6. doi: 10.1093/carcin/bgq127. Epub 2010 Jun 17. Carcinogenesis. 2010. PMID: 20558521 Free PMC article.
Genetic variants in the calcium/vitamin D metabolic pathway may be related to risk for colorectal cancer. While several investigations of vitamin D receptor (VDR) polymorphisms and colorectal cancer have been conducted, no studies to date have evaluated the a …
Genetic variants in the calcium/vitamin D metabolic pathway may be related to risk for colorectal cancer. While several investigation …
Beta-ionone inhibits colonic aberrant crypt foci formation in rats, suppresses cell growth, and induces retinoid X receptor-alpha in human colon cancer cells.
Janakiram NB, Cooma I, Mohammed A, Steele VE, Rao CV. Janakiram NB, et al. Mol Cancer Ther. 2008 Jan;7(1):181-90. doi: 10.1158/1535-7163.MCT-07-0529. Mol Cancer Ther. 2008. PMID: 18202021 Free article.
Beta-ionone, an end-ring analogue of beta-carotenoid, which is a constituent of vegetables and fruits, has been analyzed for colon cancer chemoprevention and treatment. beta-Ionone induced cell growth inhibition and apoptosis in human colon cancer HCT1 …
Beta-ionone, an end-ring analogue of beta-carotenoid, which is a constituent of vegetables and fruits, has been analyzed for colon
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