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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1985 1
1987 3
1992 6
1993 12
1994 23
1995 34
1996 22
1997 26
1998 25
1999 30
2000 32
2001 37
2002 41
2003 41
2004 64
2005 79
2006 76
2007 86
2008 93
2009 88
2010 78
2011 83
2012 77
2013 87
2014 83
2015 94
2016 74
2017 69
2018 77
2019 82
2020 49
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1,488 results
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Page 1
Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA.
Chandra V, Huang P, Hamuro Y, Raghuram S, Wang Y, Burris TP, Rastinejad F. Chandra V, et al. Nature. 2008 Nov 20;456(7220):350-6. doi: 10.1038/nature07413. Nature. 2008. PMID: 19043829 Free PMC article.
The peroxisome proliferator-activated receptors (PPARs) form heterodimers with the retinoid X receptor (RXR), and PPAR-gamma has been intensively studied as a drug target because of its link to insulin sensitization. ...Here we present structures of intact PP …
The peroxisome proliferator-activated receptors (PPARs) form heterodimers with the retinoid X receptor (RXR), and PPAR- …
Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.
Natrajan MS, de la Fuente AG, Crawford AH, Linehan E, Nuñez V, Johnson KR, Wu T, Fitzgerald DC, Ricote M, Bielekova B, Franklin RJ. Natrajan MS, et al. Brain. 2015 Dec;138(Pt 12):3581-97. doi: 10.1093/brain/awv289. Epub 2015 Oct 12. Brain. 2015. PMID: 26463675 Free PMC article.
In this study, we show that expression of genes involved in the retinoid X receptor pathway are decreased with ageing in both myelin-phagocytosing human monocytes and mouse macrophages using a combination of in vivo and in vitro approaches. Disruption of r
In this study, we show that expression of genes involved in the retinoid X receptor pathway are decreased with ageing i …
Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha.
Chorley BN, Campbell MR, Wang X, Karaca M, Sambandan D, Bangura F, Xue P, Pi J, Kleeberger SR, Bell DA. Chorley BN, et al. Nucleic Acids Res. 2012 Aug;40(15):7416-29. doi: 10.1093/nar/gks409. Epub 2012 May 11. Nucleic Acids Res. 2012. PMID: 22581777 Free PMC article.
Validation of selected candidate genes using parallel ChIP techniques and in NRF2-silenced cell lines indicated that the expression of about two-thirds of the candidates are likely to be directly NRF2-dependent including retinoid X receptor alpha (R
Validation of selected candidate genes using parallel ChIP techniques and in NRF2-silenced cell lines indicated that the expression of about …
Retinoid X Receptor Alpha Nitro-ligand Z-10 and Its Optimized Derivative Z-36 Reduce β-Amyloid Plaques in Alzheimer's Disease Mouse Model.
Ren G, Bao W, Zeng Z, Zhang W, Shang C, Wang M, Su Y, Zhang XK, Zhou H. Ren G, et al. Mol Pharm. 2019 Feb 4;16(2):480-488. doi: 10.1021/acs.molpharmaceut.8b00096. Epub 2018 Dec 31. Mol Pharm. 2019. PMID: 29995422
Bexarotene, an agonist of retinoid X receptor alpha (RXRα), has been shown to increase the expression of apoE, ABCA1, and ABCG1 by activating RXR/LXR and RXR/PPAR heterodimers, resulting in amyloid β (Aβ)-protein clearance in the brain of an Alzheimer' …
Bexarotene, an agonist of retinoid X receptor alpha (RXRα), has been shown to increase the expression of apoE, A …
Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation.
Halstead AM, Kapadia CD, Bolzenius J, Chu CE, Schriefer A, Wartman LD, Bowman GR, Arora VK. Halstead AM, et al. Elife. 2017 Nov 16;6:e30862. doi: 10.7554/eLife.30862. Elife. 2017. PMID: 29143738 Free PMC article.
Here, we characterize mutant RXRA, demonstrating it induces enhancer/promoter activity in the context of RXRA/PPAR heterodimers in human bladder cancer cells. ...Similarly, mutant RXRA stimulates growth-factor-independent growth of Trp53/Kdm6a null bladder or …
Here, we characterize mutant RXRA, demonstrating it induces enhancer/promoter activity in the context of RXRA/PPAR heterodimer …
Silencing Retinoid X Receptor Alpha Expression Enhances Early-Stage Hepatitis B Virus Infection In Cell Cultures.
Song M, Sun Y, Tian J, He W, Xu G, Jing Z, Li W. Song M, et al. J Virol. 2018 Mar 28;92(8):e01771-17. doi: 10.1128/JVI.01771-17. Print 2018 Apr 15. J Virol. 2018. PMID: 29437960 Free PMC article.
Hepatic lipid metabolism is controlled by a complicated transcription factor network centered on retinoid X receptor alpha (RXRα). ...By a series of genetic studies in combination with transcriptome analysis and pharmacological assays, we here investig …
Hepatic lipid metabolism is controlled by a complicated transcription factor network centered on retinoid X receptor
Ligand binding and heterodimerization with retinoid X receptor α (RXRα) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding.
Wang N, Zou Q, Xu J, Zhang J, Liu J. Wang N, et al. J Biol Chem. 2018 Nov 23;293(47):18180-18191. doi: 10.1074/jbc.RA118.004652. Epub 2018 Oct 1. J Biol Chem. 2018. PMID: 30275017 Free PMC article.
Nuclear receptor farnesoid X receptor (FXR) functions as the major bile acid sensor coordinating cholesterol metabolism, lipid homeostasis, and absorption of dietary fats and vitamins. ...FXR and nuclear receptor retinoid X receptor
Nuclear receptor farnesoid X receptor (FXR) functions as the major bile acid sensor coordinating cholesterol metabolism …
Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.
Li M, Hener P, Zhang Z, Kato S, Metzger D, Chambon P. Li M, et al. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11736-41. doi: 10.1073/pnas.0604575103. Epub 2006 Jul 31. Proc Natl Acad Sci U S A. 2006. PMID: 16880407 Free PMC article.
We have demonstrated that cytokine thymic stromal lymphopoietin (TSLP), whose expression is rapidly induced upon keratinocyte-selective ablation of retinoid X receptors (RXRs) -alpha and -beta in the mouse (RXRalphabeta(ep-/-) mice), plays a key role in initi …
We have demonstrated that cytokine thymic stromal lymphopoietin (TSLP), whose expression is rapidly induced upon keratinocyte-selective abla …
The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling.
Ma X, Warnier M, Raynard C, Ferrand M, Kirsh O, Defossez PA, Martin N, Bernard D. Ma X, et al. Aging Cell. 2018 Dec;17(6):e12831. doi: 10.1111/acel.12831. Epub 2018 Sep 14. Aging Cell. 2018. PMID: 30216632 Free PMC article.
Interestingly, we discovered that the retinoid X receptor alpha (RXRA), which belongs to the nuclear receptor family, represses ITPR2 expression and regulates calcium signaling though ITPR2 and the mitochondrial calcium uniporter (MCU). K …
Interestingly, we discovered that the retinoid X receptor alpha (RXRA), which belongs to the nuclear r
ENHO, RXRA, and LXRA polymorphisms and dyslipidaemia, related comorbidities and survival in haemodialysis patients.
Grzegorzewska AE, Niepolski L, Świderska MK, Mostowska A, Stolarek I, Warchoł W, Figlerowicz M, Jagodziński PP. Grzegorzewska AE, et al. BMC Med Genet. 2018 Nov 9;19(1):194. doi: 10.1186/s12881-018-0708-4. BMC Med Genet. 2018. PMID: 30413149 Free PMC article.
BACKGROUND: The energy homeostasis-associated gene (ENHO), retinoid X receptor alpha gene (RXRA), and liver X receptor alpha gene (LXRA) are involved in adipogenic/lipogenic regulation. ...ENHO, RXRA, and LXRA SNPs, s …
BACKGROUND: The energy homeostasis-associated gene (ENHO), retinoid X receptor alpha gene (RXRA), and liv …
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