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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
1999 3
2000 8
2001 9
2002 11
2003 14
2004 19
2005 17
2006 19
2007 23
2008 28
2009 25
2010 30
2011 18
2012 29
2013 29
2014 22
2015 26
2016 24
2017 22
2018 16
2019 20
2020 18
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373 results
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Page 1
Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 2: Prediction of Decreased Substrate Exposure After Rifabutin or Carbamazepine.
Lutz JD, Kirby BJ, Wang L, Song Q, Ling J, Massetto B, Worth A, Kearney BP, Mathias A. Lutz JD, et al. Clin Pharmacol Ther. 2018 Dec;104(6):1191-1198. doi: 10.1002/cpt.1072. Epub 2018 Apr 26. Clin Pharmacol Ther. 2018. PMID: 29569712 Free PMC article. Clinical Trial.
Rifampin demonstrated dose-dependent relative induction between cytochrome P (CYP)3A and P-glycoprotein (P-gp), organic anion transporting polypeptides (OATPs), or CYP2C9; P-gp, OATP, and CYP2C9 induction was one drug-drug interaction (DDI) category lower than that observe
Rifampin demonstrated dose-dependent relative induction between cytochrome P (CYP)3A and P-glycoprotein (P-gp), organic anion transpo
Insights into CYP2B6-mediated drug-drug interactions.
Hedrich WD, Hassan HE, Wang H. Hedrich WD, et al. Acta Pharm Sin B. 2016 Sep;6(5):413-425. doi: 10.1016/j.apsb.2016.07.016. Epub 2016 Aug 9. Acta Pharm Sin B. 2016. PMID: 27709010 Free PMC article. Review.
The expression of CYP2B6 is regulated primarily by the xenobiotic receptors constitutive androstane receptor (CAR) and pregnane X receptor (PXR) in the liver. ...
The expression of CYP2B6 is regulated primarily by the xenobiotic receptors constitutive androstane receptor (CAR) and pregnane X receptor ( …
An Update on Drug-induced Liver Injury.
Devarbhavi H. Devarbhavi H. J Clin Exp Hepatol. 2012 Sep;2(3):247-59. doi: 10.1016/j.jceh.2012.05.002. Epub 2012 Sep 21. J Clin Exp Hepatol. 2012. PMID: 25755441 Free PMC article. Review.
Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 1: Establishing Induction Relationships Using Ascending Dose Rifampin.
Lutz JD, Kirby BJ, Wang L, Song Q, Ling J, Massetto B, Worth A, Kearney BP, Mathias A. Lutz JD, et al. Clin Pharmacol Ther. 2018 Dec;104(6):1182-1190. doi: 10.1002/cpt.1073. Epub 2018 Apr 19. Clin Pharmacol Ther. 2018. PMID: 29569723 Free PMC article. Clinical Trial.
The objective of this study was to establish relative induction relationships between CYP3A and drug transporters (P-glycoprotein (P-gp), organic anion transporting polypeptide (OATP), and breast cancer resistance protein (BCRP)) or other P450s (CYP2C9 and CYP1A2) using ascending …
The objective of this study was to establish relative induction relationships between CYP3A and drug transporters (P-glycoprotein (P-gp), or …
Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4.
Zhou SF. Zhou SF. Curr Drug Metab. 2008 May;9(4):310-22. doi: 10.2174/138920008784220664. Curr Drug Metab. 2008. PMID: 18473749 Review.
A small number of drugs such as rifampin, phenytoin and ritonavir are identified as inducers of CYP3A4. The orphan nuclear receptor, pregnane X receptor (PXR), have been found to play a critical role in the induction of CYP3A4. ...
A small number of drugs such as rifampin, phenytoin and ritonavir are identified as inducers of CYP3A4. The orphan nuclear receptor, …
Cholestatic Itch Management.
Mittal A. Mittal A. Curr Probl Dermatol. 2016;50:142-8. doi: 10.1159/000446057. Epub 2016 Aug 23. Curr Probl Dermatol. 2016. PMID: 27578083 Review.
Treatment options for patients with cholestatic itch include the anion exchange resin cholestyramine, bile acid ursodeoxycholic acid, PXR agonist rifampicin, opioid antagonist naltrexone, and the serotonin inhibitor sertraline. ...
Treatment options for patients with cholestatic itch include the anion exchange resin cholestyramine, bile acid ursodeoxycholic acid, PXR
Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes.
Moscovitz JE, Kalgutkar AS, Nulick K, Johnson N, Lin Z, Goosen TC, Weng Y. Moscovitz JE, et al. J Pharmacol Exp Ther. 2018 May;365(2):262-271. doi: 10.1124/jpet.117.247296. Epub 2018 Feb 12. J Pharmacol Exp Ther. 2018. PMID: 29440451
The goal of this research was to establish PXR-/CAR-/AhR-specific drug-metabolizing enzyme (DME) and transporter gene expression signatures in sandwich-cultured cryopreserved human hepatocytes using selective activators of PXR (rifampin), CAR (CITCO), and AhR …
The goal of this research was to establish PXR-/CAR-/AhR-specific drug-metabolizing enzyme (DME) and transporter gene expression sign …
Pregnane X receptor activation constrains mucosal NF-κB activity in active inflammatory bowel disease.
Deuring JJ, Li M, Cao W, Chen S, Wang W, de Haar C, van der Woude CJ, Peppelenbosch M. Deuring JJ, et al. PLoS One. 2019 Oct 3;14(10):e0221924. doi: 10.1371/journal.pone.0221924. eCollection 2019. PLoS One. 2019. PMID: 31581194 Free PMC article.
METHODS: We stimulate a total of 106 colonic biopsies from 19 Crohn's disease patients with active disease, 36 colonic biopsies from 8 control patients, colonic organoids and various cell culture models (either proficient or genetically deficient with respect to PXR
METHODS: We stimulate a total of 106 colonic biopsies from 19 Crohn's disease patients with active disease, 36 colonic biopsies from …
Rifampicin, not vitamin E, suppresses parenteral nutrition-associated liver disease development through the pregnane X receptor pathway in piglets.
Guthrie G, Stoll B, Chacko S, Lauridsen C, Plat J, Burrin D. Guthrie G, et al. Am J Physiol Gastrointest Liver Physiol. 2020 Jan 1;318(1):G41-G52. doi: 10.1152/ajpgi.00193.2019. Epub 2019 Oct 11. Am J Physiol Gastrointest Liver Physiol. 2020. PMID: 31604032
We hypothesize that this occurs via vitamin E activation of pregnane X receptor (PXR)-mediated pathways involved in bile acid metabolism. ...We conclude rifampicin modified markers of PNALD development by increased metabolism of bile acids and potentially suppressed …
We hypothesize that this occurs via vitamin E activation of pregnane X receptor (PXR)-mediated pathways involved in bile acid metabol …
Functional polarization of human hepatoma HepaRG cells in response to forskolin.
Mayati A, Moreau A, Le Vée M, Bruyère A, Jouan E, Denizot C, Parmentier Y, Fardel O. Mayati A, et al. Sci Rep. 2018 Oct 31;8(1):16115. doi: 10.1038/s41598-018-34421-8. Sci Rep. 2018. PMID: 30382126 Free PMC article.
These polarizing/differentiating effects of FSK were next shown to reflect not only the generation of cAMP, but also the activation of the xenobiotic sensing receptors PXR and FXR by FSK. Co-treatment of HepaRG cells by the cAMP analog Sp-5,6-DCl-cBIMPS and the reference …
These polarizing/differentiating effects of FSK were next shown to reflect not only the generation of cAMP, but also the activation of the x …
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