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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1983 1
1984 2
1985 4
1986 2
1987 6
1988 8
1989 6
1990 6
1991 12
1992 8
1993 13
1994 12
1995 12
1996 17
1997 18
1998 21
1999 28
2000 26
2001 30
2002 35
2003 29
2004 36
2005 38
2006 55
2007 58
2008 65
2009 68
2010 62
2011 51
2012 45
2013 44
2014 28
2015 41
2016 37
2017 41
2018 22
2019 30
2020 38
2021 7
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962 results
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Page 1
The etiology of rheumatoid arthritis.
Scherer HU, Häupl T, Burmester GR. Scherer HU, et al. J Autoimmun. 2020 Jun;110:102400. doi: 10.1016/j.jaut.2019.102400. Epub 2020 Jan 22. J Autoimmun. 2020. PMID: 31980337 Free article. Review.
The most important genetic risk factor for RA development, the shared epitope alleles, resides in the MHC class II region. Shared epitope alleles, however, only predispose to the development of ACPA-positive RA. ...
The most important genetic risk factor for RA development, the shared epitope alleles, resides in the MHC class II region. …
Genetic implications in the pathogenesis of rheumatoid arthritis; an updated review.
Karami J, Aslani S, Jamshidi A, Garshasbi M, Mahmoudi M. Karami J, et al. Gene. 2019 Jun 20;702:8-16. doi: 10.1016/j.gene.2019.03.033. Epub 2019 Mar 20. Gene. 2019. PMID: 30904715 Review.
The heritability of RA has been accounted to be 50-60%, while the HLA involvement in heritability of the disease has been accounted to be 10-40%. It has been documented that shared epitope (SE) alleles, such as HLA-DRB1*01 and DRB1*04, some HLA alleles like HLA-DRB1 …
The heritability of RA has been accounted to be 50-60%, while the HLA involvement in heritability of the disease has been accounted to be 10 …
The shared epitope phenomenon-A potential impediment to virtual crossmatch accuracy.
Garcia-Sanchez C, Usenko CY, Herrera ND, Tambur AR. Garcia-Sanchez C, et al. Clin Transplant. 2020 Aug;34(8):e13906. doi: 10.1111/ctr.13906. Epub 2020 Jun 14. Clin Transplant. 2020. PMID: 32418254 Review.
While the development of the single antigen bead (SAB) multiplex assay has improved the sensitivity and specificity of HLA antibody detection, several limitations of the assay (specific to certain sensitized patients) can complicate accurate interpretation of results. In this rep …
While the development of the single antigen bead (SAB) multiplex assay has improved the sensitivity and specificity of HLA antibody detectio …
A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination.
Klareskog L, Stolt P, Lundberg K, Källberg H, Bengtsson C, Grunewald J, Rönnelid J, Harris HE, Ulfgren AK, Rantapää-Dahlqvist S, Eklund A, Padyukov L, Alfredsson L. Klareskog L, et al. Arthritis Rheum. 2006 Jan;54(1):38-46. doi: 10.1002/art.21575. Arthritis Rheum. 2006. PMID: 16385494 Free article.
OBJECTIVE: To investigate whether smoking and HLA-DR shared epitope (SE) genes may interact in triggering immune reactions to citrulline-modified proteins. ...
OBJECTIVE: To investigate whether smoking and HLA-DR shared epitope (SE) genes may interact in triggering immune reactions to …
Uncovering a Shared Epitope-Activated Protein Citrullination Pathway.
van Drongelen V, Ali WH, Holoshitz J. van Drongelen V, et al. J Immunol. 2020 Aug 1;205(3):579-586. doi: 10.4049/jimmunol.1901108. Epub 2020 Jun 26. J Immunol. 2020. PMID: 32591395 Free PMC article.
Rheumatoid arthritis (RA) is closely associated with shared epitope (SE)-coding HLA-DRB1 alleles and circulating anticitrullinated protein Abs (ACPA), but neither the respective pathogenic roles of SE and ACPA in RA nor the mechanisms underlying their coassociation …
Rheumatoid arthritis (RA) is closely associated with shared epitope (SE)-coding HLA-DRB1 alleles and circulating anticitrullin …
The rheumatoid arthritis HLA-DRB1 shared epitope.
Holoshitz J. Holoshitz J. Curr Opin Rheumatol. 2010 May;22(3):293-8. doi: 10.1097/BOR.0b013e328336ba63. Curr Opin Rheumatol. 2010. PMID: 20061955 Free PMC article. Review.
PURPOSE OF REVIEW: To update progress made between December 2008 and November 2009 on the role of the rheumatoid arthritis (RA)-shared epitope in the cause and pathogenesis of RA. RECENT FINDINGS: New evidence has been recently presented to suggest that noninherited …
PURPOSE OF REVIEW: To update progress made between December 2008 and November 2009 on the role of the rheumatoid arthritis (RA)-shared
HLA risk alleles and gut microbiome in ankylosing spondylitis and rheumatoid arthritis.
Xu H, Yin J. Xu H, et al. Best Pract Res Clin Rheumatol. 2019 Dec;33(6):101499. doi: 10.1016/j.berh.2020.101499. Epub 2020 Apr 9. Best Pract Res Clin Rheumatol. 2019. PMID: 32279929 Review.
In this review, first we provide evidence from animal and human studies on: if and how HLA-B27, HLA-DRB1 (shared epitope (SE)), and other HLA alleles alter the gut microbiome, then we analyzed the data for several hypotheses to explain the mechanism(s) of HLA allele …
In this review, first we provide evidence from animal and human studies on: if and how HLA-B27, HLA-DRB1 (shared epitope (SE)) …
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