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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 3
1969 2
1970 3
1971 8
1972 5
1973 14
1974 13
1975 17
1976 11
1977 22
1978 15
1979 17
1980 15
1981 14
1982 15
1983 13
1984 8
1985 18
1986 16
1987 16
1988 21
1989 21
1990 29
1991 23
1992 29
1993 25
1994 18
1995 14
1996 20
1997 35
1998 33
1999 39
2000 46
2001 48
2002 65
2003 73
2004 70
2005 105
2006 119
2007 147
2008 136
2009 166
2010 209
2011 225
2012 246
2013 278
2014 272
2015 291
2016 290
2017 336
2018 324
2019 296
2020 341
2021 74
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4,204 results
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Page 1
Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years.
Federico A, Dallio M, Loguercio C. Federico A, et al. Molecules. 2017 Jan 24;22(2):191. doi: 10.3390/molecules22020191. Molecules. 2017. PMID: 28125040 Free PMC article. Review.
Silymarin is the extract of Silybum marianum, or milk thistle, and its major active compound is silybin, which has a remarkable biological effect. ...Furthermore, silymarin/silybin use has important biological effects in non-alcoholic fatty liver disea …
Silymarin is the extract of Silybum marianum, or milk thistle, and its major active compound is silybin, which has a remarkabl …
Milk thistle in liver diseases: past, present, future.
Abenavoli L, Capasso R, Milic N, Capasso F. Abenavoli L, et al. Phytother Res. 2010 Oct;24(10):1423-32. doi: 10.1002/ptr.3207. Phytother Res. 2010. PMID: 20564545 Review.
The active complex of MT is a lipophilic extract from the seeds of the plant and is composed of three isomer flavonolignans (silybin, silydianin, and silychristin) collectively known as silymarin. Silybin is a component with the greatest degree of biological …
The active complex of MT is a lipophilic extract from the seeds of the plant and is composed of three isomer flavonolignans (silybin, …
Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases.
Abenavoli L, Izzo AA, Milić N, Cicala C, Santini A, Capasso R. Abenavoli L, et al. Phytother Res. 2018 Nov;32(11):2202-2213. doi: 10.1002/ptr.6171. Epub 2018 Aug 6. Phytother Res. 2018. PMID: 30080294 Review.
MT fruits contain a mixture of flavonolignans collectively known as silymarin, being silybin (also named silibinin) the main component. ...
MT fruits contain a mixture of flavonolignans collectively known as silymarin, being silybin (also named silibinin) the …
Metabolism, Transport and Drug-Drug Interactions of Silymarin.
Xie Y, Zhang D, Zhang J, Yuan J. Xie Y, et al. Molecules. 2019 Oct 14;24(20):3693. doi: 10.3390/molecules24203693. Molecules. 2019. PMID: 31615114 Free PMC article. Review.
Silymarin, the extract of milk thistle, and its major active flavonolignan silybin, are common products widely used in the phytotherapy of liver diseases. ...However, inconsistent results are noted in the different clinical studies due to the low bioavailability of …
Silymarin, the extract of milk thistle, and its major active flavonolignan silybin, are common products widely used in the phy …
The silymarin composition and why does it matter???
Chambers CS, Holečková V, Petrásková L, Biedermann D, Valentová K, Buchta M, Křen V. Chambers CS, et al. Food Res Int. 2017 Oct;100(Pt 3):339-353. doi: 10.1016/j.foodres.2017.07.017. Epub 2017 Jul 12. Food Res Int. 2017. PMID: 28964357 Review.
As silybin is the main component of silymarin, the literature mainly focuses on this compound, ignoring all other components. ...There are studies dealing with the analytical separation and quantification of silymarin components as well as studies focused on …
As silybin is the main component of silymarin, the literature mainly focuses on this compound, ignoring all other components. …
Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)-Chemistry, Bioavailability, and Metabolism.
Bijak M. Bijak M. Molecules. 2017 Nov 10;22(11):1942. doi: 10.3390/molecules22111942. Molecules. 2017. PMID: 29125572 Free PMC article. Review.
Milk thistle (Silybum marianum) is a medicinal plant that has been used for thousands of years as a remedy for a variety of ailments. The main component of S. marianum fruit extract (silymarin) is a flavonolignan called silybin, which is not only the major …
Milk thistle (Silybum marianum) is a medicinal plant that has been used for thousands of years as a remedy for a variety of ailments. The ma …
Silibinin is a direct inhibitor of STAT3.
Verdura S, Cuyàs E, Llorach-Parés L, Pérez-Sánchez A, Micol V, Nonell-Canals A, Joven J, Valiente M, Sánchez-Martínez M, Bosch-Barrera J, Menendez JA. Verdura S, et al. Food Chem Toxicol. 2018 Jun;116(Pt B):161-172. doi: 10.1016/j.fct.2018.04.028. Epub 2018 Apr 14. Food Chem Toxicol. 2018. PMID: 29660364
We herein combined experimental and computational efforts to delineate the mechanism of action through which the flavonolignan silibinin targets STAT3. Silibinin reduced IL-6 inducible, constitutive, and acquired feedback activation of STAT3 at tyrosine 705 (Y705). …
We herein combined experimental and computational efforts to delineate the mechanism of action through which the flavonolignan silibinin …
Nanotherapeutic silibinin: An insight of phytomedicine in healthcare reformation.
Takke A, Shende P. Takke A, et al. Nanomedicine. 2019 Oct;21:102057. doi: 10.1016/j.nano.2019.102057. Epub 2019 Jul 21. Nanomedicine. 2019. PMID: 31340181 Review.
Most of the herbal origin drugs possess water insoluble active constituents which lower the bioavailability and increase systemic clearance after administration of repeated or higher dose of drug. Silymarin is extracted from the seeds and fruits of milk thistle plant Silyb …
Most of the herbal origin drugs possess water insoluble active constituents which lower the bioavailability and increase systemic clearance …
Herb-drug interaction of silymarin or silibinin on the pharmacokinetics of trazodone in rats.
Chang JC, Wu YT, Lee WC, Lin LC, Tsai TH. Chang JC, et al. Chem Biol Interact. 2009 Dec 10;182(2-3):227-32. doi: 10.1016/j.cbi.2009.09.005. Epub 2009 Sep 16. Chem Biol Interact. 2009. PMID: 19765569
This study investigates the effects of repeated dose of silymarin and its major ingredient, silibinin, on the pharmacokinetics of the antidepressant trazodone. Treatment groups included vehicle control group, concomitant silymarin at 1.0g/kg dose, and four 7- …
This study investigates the effects of repeated dose of silymarin and its major ingredient, silibinin, on the pharmacokinetics …
Nano-soldiers Ameliorate Silibinin Delivery: A Review Study.
Ashrafizadeh M, Ahmadi Z, Mohammadinejad R, Farkhondeh T, Samarghandian S. Ashrafizadeh M, et al. Curr Drug Deliv. 2020;17(1):15-22. doi: 10.2174/1567201816666191112113031. Curr Drug Deliv. 2020. PMID: 31721702 Review.
For this reason, nanotechnology application for delivering flavonoids to tumor sites has recently received significant attention. Silibinin is a key member of flavonoids and a bioactive component of silymarin, which is widely isolated from Silybum marianum. ...In th …
For this reason, nanotechnology application for delivering flavonoids to tumor sites has recently received significant attention. Silibin …
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