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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 3
1981 10
1982 5
1983 9
1984 14
1985 21
1986 20
1987 24
1988 29
1989 55
1990 69
1991 119
1992 146
1993 142
1994 229
1995 241
1996 283
1997 277
1998 379
1999 454
2000 504
2001 578
2002 595
2003 662
2004 703
2005 801
2006 890
2007 816
2008 830
2009 841
2010 892
2011 902
2012 946
2013 930
2014 843
2015 823
2016 795
2017 810
2018 736
2019 682
2020 422
2021 1
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16,690 results
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Structure and function of matrix metalloproteinases and TIMPs.
Nagase H, Visse R, Murphy G. Nagase H, et al. Cardiovasc Res. 2006 Feb 15;69(3):562-73. doi: 10.1016/j.cardiores.2005.12.002. Epub 2006 Jan 5. Cardiovasc Res. 2006. PMID: 16405877 Review.
Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular environment of cells and degrade both matrix and non-matrix proteins. ...They are multi-domain proteins and their activities are regulated by tissue inhibitors of metalloprotei
Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular environment of cells and degrade both matrix a …
TIMPs: versatile extracellular regulators in cancer.
Jackson HW, Defamie V, Waterhouse P, Khokha R. Jackson HW, et al. Nat Rev Cancer. 2017 Jan;17(1):38-53. doi: 10.1038/nrc.2016.115. Epub 2016 Dec 9. Nat Rev Cancer. 2017. PMID: 27932800 Review.
Here, we review how the four non-redundant tissue inhibitors of metalloproteinases (TIMPs) regulate the pericellular proteolysis of a vast range of matrix and cell surface proteins, generating simultaneous effects on tumour architecture and cell signalling. ...Futur …
Here, we review how the four non-redundant tissue inhibitors of metalloproteinases (TIMPs) regulate the pericellular proteolys …
Association between tissue inhibitor of metalloproteinase (TIMP) genetic polymorphisms and primary ovarian insufficiency (POI).
An HJ, Ahn EH, Kim JO, Park HS, Ryu CS, Cho SH, Kim JH, Lee WS, Kim NK. An HJ, et al. Maturitas. 2019 Feb;120:77-82. doi: 10.1016/j.maturitas.2018.11.018. Epub 2018 Nov 27. Maturitas. 2019. PMID: 30583769
BACKGROUND: Until now, an association between tissue inhibitor of metalloproteinase (TIMP) polymorphisms and primary ovarian insufficiency (POI) has not been identified. The aim of our study was to investigate whether the TIMP polymorphisms TIMP1T > C (rs4 …
BACKGROUND: Until now, an association between tissue inhibitor of metalloproteinase (TIMP) polymorphisms and primary ov …
Tissue Inhibitor of Metalloproteinase-4 Triggers Apoptosis in Cervical Cancer Cells.
Lizarraga F, Ceballos-Cancino G, Espinosa M, Vazquez-Santillan K, Maldonado V, Melendez-Zajgla J. Lizarraga F, et al. PLoS One. 2015 Aug 20;10(8):e0135929. doi: 10.1371/journal.pone.0135929. eCollection 2015. PLoS One. 2015. PMID: 26291714 Free PMC article.
Tissue inhibitor of metalloproteinase-4 (TIMP-4) is a member of extracellular matrix (ECM) metalloproteinases inhibitors that has pleiotropic functions. ...Consistent with these findings, regulators of apoptosis from Inhibitors of Apoptosis Proteins (I
Tissue inhibitor of metalloproteinase-4 (TIMP-4) is a member of extracellular matrix (ECM) metalloproteinases in
Tissue inhibitor of matrix metalloproteinase-3 expression in the mouse uterus during implantation and artificially induced decidualization.
Bany BM, Schultz GA. Bany BM, et al. Mol Reprod Dev. 2001 Jun;59(2):159-67. doi: 10.1002/mrd.1018. Mol Reprod Dev. 2001. PMID: 11389550
During implantation in mice, tissue inhibitor of matrix metalloproteinases-3 is believed to play a key role in inhibiting matrix metalloproteinase activity associated with embryo invasion and tissue remodeling. ...The results of this study furth …
During implantation in mice, tissue inhibitor of matrix metalloproteinases-3 is believed to play a key role in inhibiti …
Circulating Tissue Inhibitor of Metalloproteinase-4 levels are not a Predictor of Preeclampsia in the period between 20 and 25 Weeks of Gestation.
Sandrim VC, Machado J, Bettiol H, Barbieri MA, Cardoso VC, Palei AC, Cavalli RC. Sandrim VC, et al. Rev Bras Ginecol Obstet. 2018 Dec;40(12):757-762. doi: 10.1055/s-0038-1676056. Epub 2018 Dec 7. Rev Bras Ginecol Obstet. 2018. PMID: 30536270 Free article. English.
OBJECTIVE:  To evaluate whether the circulating level of tissue inhibitor of metalloproteinase-4 (TIMP-4) in the period between 20 and 25 weeks of gestation is a predictor of preeclampsia. ...
OBJECTIVE:  To evaluate whether the circulating level of tissue inhibitor of metalloproteinase-4 (TIMP-4) in the period …
Tissue Inhibitor of Metalloproteinase-1: Actions beyond Matrix Metalloproteinase Inhibition.
Lindsey ML, Yabluchanskiy A, Ma Y. Lindsey ML, et al. Cardiology. 2015;132(3):147-50. doi: 10.1159/000433419. Epub 2015 Aug 1. Cardiology. 2015. PMID: 26279068 Free PMC article. No abstract available.
Tissue inhibitor of metalloproteinase-2 (TIMP-2) from red seabream (Pagrus major): Molecular cloning and biochemical characterization of highly expressed recombinant protein.
Zhong C, Cao MJ, Shu M, Sun LC, Yang HH, Wu GP. Zhong C, et al. Fish Shellfish Immunol. 2019 Dec;95:556-563. doi: 10.1016/j.fsi.2019.11.006. Epub 2019 Nov 3. Fish Shellfish Immunol. 2019. PMID: 31693944
The tissue inhibitor of metalloproteinase-2 (TIMP-2) is originally characterized as an endogenous inhibitor of matrix metalloproteinases (MMPs) to response collagenolysis associated with immune challenge. ...
The tissue inhibitor of metalloproteinase-2 (TIMP-2) is originally characterized as an endogenous inhibitor of m …
Tissue inhibitor of metalloproteinases-4. The road less traveled.
Melendez-Zajgla J, Del Pozo L, Ceballos G, Maldonado V. Melendez-Zajgla J, et al. Mol Cancer. 2008 Nov 21;7:85. doi: 10.1186/1476-4598-7-85. Mol Cancer. 2008. PMID: 19025595 Free PMC article. Review.
Tissue inhibitors of metalloproteinases (TIMPs) regulate diverse processes, including extracellular matrix (ECM) remodeling, and growth factors and their receptors' activities through the inhibition of matrix metalloproteinases (MMPs). ...Initially cloned in
Tissue inhibitors of metalloproteinases (TIMPs) regulate diverse processes, including extracellular matrix (ECM) remodeling, a
Tissue inhibitor of metalloproteinases (TIMPs) in heart failure.
Moore L, Fan D, Basu R, Kandalam V, Kassiri Z. Moore L, et al. Heart Fail Rev. 2012 Sep;17(4-5):693-706. doi: 10.1007/s10741-011-9266-y. Heart Fail Rev. 2012. PMID: 21717224 Review.
The ECM is a dynamic entity that undergoes constant turnover, and the integrity of its network structure is maintained by a balance in the function of matrix metalloproteinases (MMPs) and their inhibitors, the tissue inhibitor of metalloproteinases (TI …
The ECM is a dynamic entity that undergoes constant turnover, and the integrity of its network structure is maintained by a balance in the f …
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