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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 1
1980 1
1981 1
1984 1
1986 1
1988 1
1989 2
1990 3
1991 1
1992 6
1993 4
1994 5
1995 1
1996 3
1997 6
1998 2
1999 5
2000 10
2001 5
2002 14
2003 11
2004 5
2005 7
2006 9
2007 7
2008 6
2009 8
2010 10
2011 7
2012 7
2013 15
2014 13
2015 17
2016 8
2017 11
2018 11
2019 8
2020 5
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216 results
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Page 1
Bile acid metabolism and signaling.
Chiang JY. Chiang JY. Compr Physiol. 2013 Jul;3(3):1191-212. doi: 10.1002/cphy.c120023. Compr Physiol. 2013. PMID: 23897684 Free PMC article. Review.
Bile acids are important physiological agents for intestinal nutrient absorption and biliary secretion of lipids, toxic metabolites, and xenobiotics. ...Toxic bile acids may cause inflammation, apoptosis, and cell death. On the other hand, bile
Bile acids are important physiological agents for intestinal nutrient absorption and biliary secretion of lipids, toxic metabo
Fibrates and cholestasis.
Ghonem NS, Assis DN, Boyer JL. Ghonem NS, et al. Hepatology. 2015 Aug;62(2):635-43. doi: 10.1002/hep.27744. Epub 2015 Mar 23. Hepatology. 2015. PMID: 25678132 Free PMC article. Review.
Cholestasis, including primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), results from an impairment or disruption of bile production and causes intracellular retention of toxic bile constituents, including bile salts. ...One of …
Cholestasis, including primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), results from an impairment or disruption of …
Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases.
Li Y, Tang R, Leung PSC, Gershwin ME, Ma X. Li Y, et al. Autoimmun Rev. 2017 Sep;16(9):885-896. doi: 10.1016/j.autrev.2017.07.002. Epub 2017 Jul 8. Autoimmun Rev. 2017. PMID: 28698093 Review.
Autoimmune cholestatic liver diseases, including primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), are manifested as an impairment of normal bile flow and excessive accumulation of potentially toxic bile acids. ...In addition, the in …
Autoimmune cholestatic liver diseases, including primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), are manifested …
Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis.
Kettner NM, Voicu H, Finegold MJ, Coarfa C, Sreekumar A, Putluri N, Katchy CA, Lee C, Moore DD, Fu L. Kettner NM, et al. Cancer Cell. 2016 Dec 12;30(6):909-924. doi: 10.1016/j.ccell.2016.10.007. Epub 2016 Nov 23. Cancer Cell. 2016. PMID: 27889186 Free PMC article.
This pathophysiological pathway is driven by jet-lag-induced genome-wide gene deregulation and global liver metabolic dysfunction, with nuclear receptor-controlled cholesterol/bile acid and xenobiotic metabolism among the top deregulated pathways. Ablation of farnesoid X r …
This pathophysiological pathway is driven by jet-lag-induced genome-wide gene deregulation and global liver metabolic dysfunction, with nucl …
Bile Acids.
[No authors listed] [No authors listed] 2017 Sep 25. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. 2012–. PMID: 31643938 Free Books & Documents. Review.
Thus, increased bile acid levels in hepatocytes may account for some of the liver damage in cholestatic liver diseases. Bile acids can be used as therapeutic agents, particularly in patients with cholestatic liver diseases where administered bile acids (such …
Thus, increased bile acid levels in hepatocytes may account for some of the liver damage in cholestatic liver diseases. Bile a …
Role of Bile Acids and the Biliary HCO(3)(-) Umbrella in the Pathogenesis of Primary Biliary Cholangitis.
van Niekerk J, Kersten R, Beuers U. van Niekerk J, et al. Clin Liver Dis. 2018 Aug;22(3):457-479. doi: 10.1016/j.cld.2018.03.013. Epub 2018 May 19. Clin Liver Dis. 2018. PMID: 30259847 Review.
The biliary HCO(3)(-) umbrella hypothesis states that human cholangiocytes and hepatocytes create a protective apical alkaline barrier against millimolar concentrations of potentially toxic glycine-conjugated bile salts in bile by secreting HCO(3)(-) into the …
The biliary HCO(3)(-) umbrella hypothesis states that human cholangiocytes and hepatocytes create a protective apical alkaline barrier again …
From Reflux Esophagitis to Esophageal Adenocarcinoma.
Souza RF. Souza RF. Dig Dis. 2016;34(5):483-90. doi: 10.1159/000445225. Epub 2016 Jun 22. Dig Dis. 2016. PMID: 27331918 Free PMC article. Review.
Oral treatment with ursodeoxycholic acid prevents the esophageal DNA damage and NF-x03BA;B activation induced by toxic bile acids. Altering bile acid composition might be another approach to cancer prevention....
Oral treatment with ursodeoxycholic acid prevents the esophageal DNA damage and NF-x03BA;B activation induced by toxic bile ac …
Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases.
Trauner M, Fickert P, Halilbasic E, Moustafa T. Trauner M, et al. Wien Med Wochenschr. 2008;158(19-20):542-8. doi: 10.1007/s10354-008-0592-1. Wien Med Wochenschr. 2008. PMID: 18998069 Review.
Alterations in bile secretion at the hepatocellular and cholangiocellular levels may cause cholestasis. Formation of 'toxic bile' may be the consequence of abnormal bile composition and can result in hepatocellular and/or bile duct injury. ...Ot …
Alterations in bile secretion at the hepatocellular and cholangiocellular levels may cause cholestasis. Formation of 'toxic
Toxic bile and sclerosing cholangitis: Is there a role for pharmacological interruption of the bile acid enterohepatic circulation?
Dawson PA. Dawson PA. Hepatology. 2016 Feb;63(2):363-4. doi: 10.1002/hep.28363. Epub 2016 Jan 6. Hepatology. 2016. PMID: 26600416 Free PMC article. No abstract available.
Bile acids are toxic for isolated cardiac mitochondria: a possible cause for hepatic-derived cardiomyopathies?
Ferreira M, Coxito PM, Sardão VA, Palmeira CM, Oliveira PJ. Ferreira M, et al. Cardiovasc Toxicol. 2005;5(1):63-73. doi: 10.1385/ct:5:1:063. Cardiovasc Toxicol. 2005. PMID: 15738586
Cholestasis and other liver diseases may affect the heart through the toxic effects of the retained bile acids on cardiac mitochondria, which could explain the origin of hepatic-derived cardiomyopathies. The objective of this work was to test the hypothesis that …
Cholestasis and other liver diseases may affect the heart through the toxic effects of the retained bile acids on cardiac mito …
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