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1982 1
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Immunopathogenesis of IBD: current state of the art.
de Souza HS, Fiocchi C. de Souza HS, et al. Nat Rev Gastroenterol Hepatol. 2016 Jan;13(1):13-27. doi: 10.1038/nrgastro.2015.186. Epub 2015 Dec 2. Nat Rev Gastroenterol Hepatol. 2016. PMID: 26627550 Review.
IBD is a chronic inflammatory condition of the gastrointestinal tract encompassing two main clinical entities: Crohn's disease and ulcerative colitis. ...Both Crohn's disease and ulcerative colitis are associated with multiple pathogenic factors includ …
IBD is a chronic inflammatory condition of the gastrointestinal tract encompassing two main clinical entities: Crohn's disease and ulcera
HSPA6 is an ulcerative colitis susceptibility factor that is induced by cigarette smoke and protects intestinal epithelial cells by stabilizing anti-apoptotic Bcl-XL.
Regeling A, Imhann F, Volders HH, Blokzijl T, Bloks VW, Weersma RK, Dijkstra G, Faber KN. Regeling A, et al. Biochim Biophys Acta. 2016 Apr;1862(4):788-796. doi: 10.1016/j.bbadis.2016.01.020. Epub 2016 Jan 26. Biochim Biophys Acta. 2016. PMID: 26826017 Free article.
BACKGROUND: Cigarette smoking ameliorates ulcerative colitis (UC) and aggravates Crohn's disease (CD). Cigarette smoke suppresses inflammation-induced apoptosis in intestinal epithelial cells (DLD-1), which may explain its protective effect in UC. ...CONCLUSIONS: HS …
BACKGROUND: Cigarette smoking ameliorates ulcerative colitis (UC) and aggravates Crohn's disease (CD). Cigarette smoke suppres …
ATG16L1 T300A polymorphism is associated with Crohn's disease in a Northwest Greek cohort, but ECM1 T130M and G290S polymorphisms are not associated with ulcerative colitis.
Tsianos VE, Kostoulas C, Gazouli M, Frillingos S, Georgiou I, Christodoulou DK, Katsanos KH, Tsianos EV. Tsianos VE, et al. Ann Gastroenterol. 2020 Jan-Feb;33(1):38-44. doi: 10.20524/aog.2019.0434. Epub 2019 Nov 21. Ann Gastroenterol. 2020. PMID: 31892796 Free PMC article.
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) are well-described disease entities with unknown etiopathogenesis. ...The role of susceptibility gene polymorphisms, such as ATG16L1 T300A and ECM1 T130M and G290S, is well-described, althoug …
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) are well-described disease entities with unknown etiopathogenesis …
Intestinal Epithelial Cell Autophagy Is Required to Protect against TNF-Induced Apoptosis during Chronic Colitis in Mice.
Pott J, Kabat AM, Maloy KJ. Pott J, et al. Cell Host Microbe. 2018 Feb 14;23(2):191-202.e4. doi: 10.1016/j.chom.2017.12.017. Epub 2018 Jan 18. Cell Host Microbe. 2018. PMID: 29358084 Free article.
Genome-wide association studies have linked polymorphisms in the autophagy gene ATG16L1 with susceptibility to inflammatory bowel disease (IBD). ...These findings suggest that the IBD susceptibility gene ATG16L1 and the process of autophagy within the …
Genome-wide association studies have linked polymorphisms in the autophagy gene ATG16L1 with susceptibility to inflammatory bo …
The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population.
Glas J, Konrad A, Schmechel S, Dambacher J, Seiderer J, Schroff F, Wetzke M, Roeske D, Török HP, Tonenchi L, Pfennig S, Haller D, Griga T, Klein W, Epplen JT, Folwaczny C, Lohse P, Göke B, Ochsenkühn T, Mussack T, Folwaczny M, Müller-Myhsok B, Brand S. Glas J, et al. Am J Gastroenterol. 2008 Mar;103(3):682-91. doi: 10.1111/j.1572-0241.2007.01694.x. Epub 2007 Dec 20. Am J Gastroenterol. 2008. PMID: 18162085
METHODS: Genomic DNA from 2,890 Caucasians including 768 patients with CD, 507 patients with ulcerative colitis (UC), and 1,615 healthy controls was analyzed for 9 different ATG16L1 single nucleotide polymorphisms (SNPs). ...CONCLUSION: ATG16L1 is a CD susceptibi
METHODS: Genomic DNA from 2,890 Caucasians including 768 patients with CD, 507 patients with ulcerative colitis (UC), and 1,61 …
Identification of critical variants within SLC44A4, an ulcerative colitis susceptibility gene identified in a GWAS in north Indians.
Gupta A, Thelma BK. Gupta A, et al. Genes Immun. 2016 Mar;17(2):105-9. doi: 10.1038/gene.2015.53. Epub 2016 Jan 7. Genes Immun. 2016. PMID: 26741288
SLC44A4 is one of the seven novel susceptibility genes that were discovered in the first ever genome-wide association study (GWAS) on ulcerative colitis (UC) in the genetically distinct north Indians. ...This highlights the importance of this gene in U …
SLC44A4 is one of the seven novel susceptibility genes that were discovered in the first ever genome-wide association study (GWAS) on …
Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis.
Villani AC, Lemire M, Louis E, Silverberg MS, Collette C, Fortin G, Nimmo ER, Renaud Y, Brunet S, Libioulle C, Belaiche J, Bitton A, Gaudet D, Cohen A, Langelier D, Rioux JD, Arnott ID, Wild GE, Rutgeerts P, Satsangi J, Vermeire S, Hudson TJ, Franchimont D. Villani AC, et al. PLoS One. 2009 Sep 28;4(9):e7154. doi: 10.1371/journal.pone.0007154. PLoS One. 2009. PMID: 19784369 Free PMC article.
The NLRP3 region was recently reported to be associated with Crohn's disease (CD) susceptibility. We therefore sought to evaluate MEFV as an inflammatory bowel disease (IBD) susceptibility gene. METHODOLOGY AND RESULTS: MEFV colonic mucosal gene expres …
The NLRP3 region was recently reported to be associated with Crohn's disease (CD) susceptibility. We therefore sought to evaluate MEF …
PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.
Glas J, Wagner J, Seiderer J, Olszak T, Wetzke M, Beigel F, Tillack C, Stallhofer J, Friedrich M, Steib C, Göke B, Ochsenkühn T, Karbalai N, Diegelmann J, Czamara D, Brand S. Glas J, et al. PLoS One. 2012;7(3):e33682. doi: 10.1371/journal.pone.0033682. Epub 2012 Mar 21. PLoS One. 2012. PMID: 22457781 Free PMC article.
BACKGROUND: Genome-wide association studies identified PTPN2 (protein tyrosine phosphatase, non-receptor type 2) as susceptibility gene for inflammatory bowel diseases (IBD). However, the exact role of PTPN2 in Crohn's disease (CD) and ulcerative colitis
BACKGROUND: Genome-wide association studies identified PTPN2 (protein tyrosine phosphatase, non-receptor type 2) as susceptibility
[Advances in research on ulcerative colitis].
Araki T, Toiyama Y, Tanaka K, Uchida K, Kusunoki M. Araki T, et al. Nihon Geka Gakkai Zasshi. 2015 Mar;116(2):104-8. Nihon Geka Gakkai Zasshi. 2015. PMID: 26050510 Japanese.
The cause of ulcerative colitis remains unknown, and there is no established medical cure for this disease. Recent progress in genome-wide association studies and research to identify the susceptibility gene have gradually determined the pathophysiolog …
The cause of ulcerative colitis remains unknown, and there is no established medical cure for this disease. Recent progress in …
Genetic polymorphisms of interleukin 8 and risk of ulcerative colitis in the Chinese population.
Li K, Yao S, Liu S, Wang B, Mao D. Li K, et al. Clin Chim Acta. 2009 Jul;405(1-2):30-4. doi: 10.1016/j.cca.2009.03.053. Epub 2009 Apr 5. Clin Chim Acta. 2009. PMID: 19348790
BACKGROUND: Interleukin-8 (IL-8), a CXC chemokine that recruits and activates inflammatory cells, plays a critical role in the pathogenesis of ulcerative colitis (UC). ...CONCLUSION: These results suggest that IL-8 is a novel susceptibility gene to UC …
BACKGROUND: Interleukin-8 (IL-8), a CXC chemokine that recruits and activates inflammatory cells, plays a critical role in the pathogenesis …
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