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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 3
1956 9
1957 10
1958 9
1959 8
1960 9
1961 7
1962 8
1963 22
1964 34
1965 21
1966 18
1967 33
1968 34
1969 31
1970 34
1971 40
1972 42
1973 36
1974 43
1975 32
1976 32
1977 44
1978 55
1979 69
1980 92
1981 125
1982 123
1983 128
1984 179
1985 202
1986 215
1987 250
1988 241
1989 276
1990 305
1991 307
1992 349
1993 367
1994 367
1995 441
1996 511
1997 550
1998 613
1999 723
2000 736
2001 748
2002 733
2003 780
2004 820
2005 876
2006 973
2007 1001
2008 1100
2009 1124
2010 1207
2011 1236
2012 1446
2013 1613
2014 1705
2015 1625
2016 1736
2017 1820
2018 1888
2019 1940
2020 1567
2021 1
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31,270 results
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Page 1
Optimizing the Clinical Use of Vancomycin.
Álvarez R, López Cortés LE, Molina J, Cisneros JM, Pachón J. Álvarez R, et al. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2601-9. doi: 10.1128/AAC.03147-14. Print 2016 May. Antimicrob Agents Chemother. 2016. PMID: 26856841 Free PMC article. Review.
Vancomycin doses must be adjusted according to body weight and the plasma trough levels of the drug. Nephrotoxicity has been associated with target vancomycin trough levels above 15 mg/liter. ...In such cases, vancomycin plasma steady-state level and creatini
Vancomycin doses must be adjusted according to body weight and the plasma trough levels of the drug. Nephrotoxicity has been associat
Vancomycin loading doses: a systematic review.
Reardon J, Lau TT, Ensom MH. Reardon J, et al. Ann Pharmacother. 2015 May;49(5):557-65. doi: 10.1177/1060028015571163. Epub 2015 Feb 23. Ann Pharmacother. 2015. PMID: 25712445 Review.
Of 6 adult studies, 4 concluded that administration of vancomycin LDs resulted in significantly more patients achieving troughs of 15 to 20 mg/L. ...CONCLUSIONS: High-quality data to guide the use of vancomycin LDs are lacking. LDs may more rapidly attain vancomy
Of 6 adult studies, 4 concluded that administration of vancomycin LDs resulted in significantly more patients achieving troughs of 15 …
Vancomycin.
Cunha BA. Cunha BA. Med Clin North Am. 1995 Jul;79(4):817-31. doi: 10.1016/s0025-7125(16)30041-4. Med Clin North Am. 1995. PMID: 7791425 Review.
Vancomycin should not be added to drug regimens for gram-positive coverage, and the empiric use of vancomycin should be discouraged to avoid the emergence of VRE. Vancomycin serum levels are no longer necessary or cost effective in most patients because va
Vancomycin should not be added to drug regimens for gram-positive coverage, and the empiric use of vancomycin should be discou
Removal of vancomycin administered during dialysis by a high-flux dialyzer.
Nyman HA, Agarwal A, Senekjian HO, Leypoldt JK, Cheung AK. Nyman HA, et al. Hemodial Int. 2018 Jul;22(3):383-387. doi: 10.1111/hdi.12637. Epub 2018 Jan 30. Hemodial Int. 2018. PMID: 29380499
Serial serum vancomycin concentrations were used to determine the removal of vancomycin when administered during dialysis. FINDINGS: Dialysis removed 35 ± 15% (range 18-56%) of the vancomycin dose when administered during the last hour of dialysis. ...Serum …
Serial serum vancomycin concentrations were used to determine the removal of vancomycin when administered during dialysis. FIN …
Does oral vancomycin use necessitate therapeutic drug monitoring?
Cimolai N. Cimolai N. Infection. 2020 Apr;48(2):173-182. doi: 10.1007/s15010-019-01374-7. Epub 2019 Nov 11. Infection. 2020. PMID: 31713055 Review.
This review examines the cumulative scientific evidence that guides therapeutic monitoring of oral vancomycin therapy. METHODS: The existing publications were reviewed from the time of the drug's inception to July 2019. ...CONCLUSION: Until systemic toxicity from or …
This review examines the cumulative scientific evidence that guides therapeutic monitoring of oral vancomycin therapy. METHODS: The e …
[Vancomycin nephrotoxicity: Frequency and mechanistic aspects].
Luque Y, Mesnard L. Luque Y, et al. Nephrol Ther. 2018 Apr;14 Suppl 1:S133-S138. doi: 10.1016/j.nephro.2018.02.009. Nephrol Ther. 2018. PMID: 29606259 French.
Vancomycin-induced oxidative stress in tubular cells and intraluminal cast formation are the two physiopathological mechanisms explaining its nephrotoxicity. ...As vancomycin is widely used and the current tendency is to increase target trough levels, it is necessar
Vancomycin-induced oxidative stress in tubular cells and intraluminal cast formation are the two physiopathological mechanisms explai
Determining the optimal vancomycin daily dose for pediatrics: a meta-analysis.
da Silva Alves GC, da Silva SD, Frade VP, Rodrigues D, Baldoni AO, de Castro WV, Sanches C. da Silva Alves GC, et al. Eur J Clin Pharmacol. 2017 Nov;73(11):1341-1353. doi: 10.1007/s00228-017-2306-3. Epub 2017 Aug 4. Eur J Clin Pharmacol. 2017. PMID: 28776198 Review.
OBJECTIVE: The objective of this study was to check which initial dose of vancomycin is needed to achieve the therapeutic target that is currently used in pediatrics. ...The vancomycin doses varied between 40 mg/kg/day to 120 mg/kg/day. The statistical tests demonst …
OBJECTIVE: The objective of this study was to check which initial dose of vancomycin is needed to achieve the therapeutic target that …
A new population pharmacokinetic model for vancomycin in patients with variable renal function: Therapeutic drug monitoring based on extended covariate model using CKD-EPI estimation.
Kim DJ, Lee DH, Ahn S, Jung J, Kiem S, Kim SW, Shin JG. Kim DJ, et al. J Clin Pharm Ther. 2019 Oct;44(5):750-759. doi: 10.1111/jcpt.12995. Epub 2019 Jun 22. J Clin Pharm Ther. 2019. PMID: 31228353
WHAT IS KNOWN AND OBJECTIVE: Although patients may have received vancomycin therapy with therapeutic drug monitoring (TDM), those treated with high-strength and long-term vancomycin therapy might have unstable and time-varying renal function. ...RESULTS: A total of …
WHAT IS KNOWN AND OBJECTIVE: Although patients may have received vancomycin therapy with therapeutic drug monitoring (TDM), those tre …
Examining the Relationship Between Vancomycin Area Under the Concentration Time Curve and Serum Trough Levels in Adults With Presumed or Documented Staphylococcal Infections.
Clark L, Skrupky LP, Servais R, Brummitt CF, Dilworth TJ. Clark L, et al. Ther Drug Monit. 2019 Aug;41(4):483-488. doi: 10.1097/FTD.0000000000000622. Ther Drug Monit. 2019. PMID: 30817704 Clinical Trial.
Two steady-state serum vancomycin levels were used to determine each patient's 24-hour AUC to minimum inhibitory concentration ratio (AUC/MIC) using a non-Bayesian, equation-based approach. ...The mean ± SD vancomycin Cmin was 16.6 ± 6.1 mg/L, and the mean AU …
Two steady-state serum vancomycin levels were used to determine each patient's 24-hour AUC to minimum inhibitory concentration …
An Evaluation of the Incidence of Nephrotoxicity After a Loading Dose of Vancomycin in Patients With Severe Renal Impairment.
Marvin JL, Levine BJ, Papas M, Rosini JM. Marvin JL, et al. J Emerg Med. 2019 Jun;56(6):701-708. doi: 10.1016/j.jemermed.2019.03.020. Epub 2019 Apr 24. J Emerg Med. 2019. PMID: 31029400
The primary outcome was incidence of nephrotoxicity after an initial high (>20 mg/kg) vs. low (≤20 mg/kg) dose of vancomycin. ...These patients should be included in future studies relating to vancomycin loading doses....
The primary outcome was incidence of nephrotoxicity after an initial high (>20 mg/kg) vs. low (≤20 mg/kg) dose of vancomycin. ...T …
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