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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1968 1
1970 3
1972 3
1973 2
1974 6
1975 9
1976 27
1977 20
1978 34
1979 55
1980 69
1981 67
1982 112
1983 130
1984 179
1985 196
1986 213
1987 221
1988 266
1989 282
1990 387
1991 360
1992 387
1993 383
1994 452
1995 474
1996 465
1997 535
1998 537
1999 582
2000 738
2001 748
2002 810
2003 822
2004 892
2005 957
2006 977
2007 1019
2008 1074
2009 1059
2010 1186
2011 1162
2012 1232
2013 1253
2014 1201
2015 1208
2016 1259
2017 1191
2018 1295
2019 1325
2020 1027
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26,185 results
Results by year
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Page 1
Chemical transformation of xenobiotics by the human gut microbiota.
Koppel N, Maini Rekdal V, Balskus EP. Koppel N, et al. Science. 2017 Jun 23;356(6344):eaag2770. doi: 10.1126/science.aag2770. Science. 2017. PMID: 28642381 Free PMC article. Review.
The human gut microbiota makes key contributions to the metabolism of ingested compounds (xenobiotics), transforming hundreds of dietary components, industrial chemicals, and pharmaceuticals into metabolites with altered activities, toxicities, and lifetimes within the bod …
The human gut microbiota makes key contributions to the metabolism of ingested compounds (xenobiotics), transforming hundreds of diet …
Gut Reactions: Breaking Down Xenobiotic-Microbiome Interactions.
Clarke G, Sandhu KV, Griffin BT, Dinan TG, Cryan JF, Hyland NP. Clarke G, et al. Pharmacol Rev. 2019 Apr;71(2):198-224. doi: 10.1124/pr.118.015768. Pharmacol Rev. 2019. PMID: 30890566 Review.
However, a growing body of evidence suggests that the gut microbiota can itself influence the actions of a range of xenobiotics, in both beneficial and potentially harmful ways. ...Despite some important observations from xenobiotic metabolism in general, there is o …
However, a growing body of evidence suggests that the gut microbiota can itself influence the actions of a range of xenobiotics, in b …
Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy.
Dallmann R, Okyar A, Lévi F. Dallmann R, et al. Trends Mol Med. 2016 May;22(5):430-445. doi: 10.1016/j.molmed.2016.03.004. Epub 2016 Apr 5. Trends Mol Med. 2016. PMID: 27066876 Review.
The importance of biological clocks for xenobiotic metabolism has gained increased attention with the discovery of the molecular circadian clockwork. ...
The importance of biological clocks for xenobiotic metabolism has gained increased attention with the discovery of the molecular circ …
Organophosphorus Xenobiotic Toxicology.
Casida JE. Casida JE. Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:309-327. doi: 10.1146/annurev-pharmtox-010716-104926. Annu Rev Pharmacol Toxicol. 2017. PMID: 28061690 Review.
Xenobiotic Conjugation with Dicarboxylic Acids.
Mitchell SC, Steventon GB. Mitchell SC, et al. Curr Drug Metab. 2018;19(13):1130-1137. doi: 10.2174/1389200219666180803142233. Curr Drug Metab. 2018. PMID: 30073923 Review.
BACKGROUND: Although it is believed widely that the various routes of xenobiotic metabolism are now all known and effectively understood, occasionally there emerges a metabolite that signals a novel biotransformation pathway, especially where the xenobiotic may in s …
BACKGROUND: Although it is believed widely that the various routes of xenobiotic metabolism are now all known and effectively underst …
From the Cover: Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.
Ramaiahgari SC, Waidyanatha S, Dixon D, DeVito MJ, Paules RS, Ferguson SS. Ramaiahgari SC, et al. Toxicol Sci. 2017 Sep 1;159(1):124-136. doi: 10.1093/toxsci/kfx122. Toxicol Sci. 2017. PMID: 28633424 Free PMC article.
Herein, we describe the development, optimization, and characterization of a novel three-dimensional (3D) spheroid model using differentiated HepaRG cells that achieve and maintain physiologically relevant levels of xenobiotic metabolism (CYP1A2, CYP2B6, and CYP3A4/5). ... …
Herein, we describe the development, optimization, and characterization of a novel three-dimensional (3D) spheroid model using differentiate …
Steroid and Xenobiotic Receptor Signalling in Apoptosis and Autophagy of the Nervous System.
Wnuk A, Kajta M. Wnuk A, et al. Int J Mol Sci. 2017 Nov 11;18(11):2394. doi: 10.3390/ijms18112394. Int J Mol Sci. 2017. PMID: 29137141 Free PMC article. Review.
Steroid and xenobiotic receptors are regulators of apoptosis and autophagy; however, their actions in various pathologies are complex. ...Most of the retinoid X receptor-related xenobiotic receptors stimulate apoptotic processes that accompany neural pathologies. .. …
Steroid and xenobiotic receptors are regulators of apoptosis and autophagy; however, their actions in various pathologies are complex …
Human cytochrome P450 enzymes 5-51 as targets of drugs and natural and environmental compounds: mechanisms, induction, and inhibition - toxic effects and benefits.
Rendic SP, Peter Guengerich F. Rendic SP, et al. Drug Metab Rev. 2018 Aug;50(3):256-342. doi: 10.1080/03602532.2018.1483401. Drug Metab Rev. 2018. PMID: 30717606 Free PMC article. Review.
Cytochrome P450 (P450, CYP) enzymes have long been of interest due to their roles in the metabolism of drugs, pesticides, pro-carcinogens, and other xenobiotic chemicals. ...
Cytochrome P450 (P450, CYP) enzymes have long been of interest due to their roles in the metabolism of drugs, pesticides, pro-carcinogens, a …
Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics.
Schulz M, Iwersen-Bergmann S, Andresen H, Schmoldt A. Schulz M, et al. Crit Care. 2012 Jul 26;16(4):R136. doi: 10.1186/cc11441. Crit Care. 2012. PMID: 22835221 Free PMC article. Review.
Therefore, it makes sense to offer a carefully referenced compilation of therapeutic and toxic plasma concentration ranges, as well as half-lives, of a large number of drugs and other xenobiotics for quick and comprehensive information. ...RESULTS: For nearly 1,000 drugs a …
Therefore, it makes sense to offer a carefully referenced compilation of therapeutic and toxic plasma concentration ranges, as well as half- …
Xenobiotic Metabolising Enzymes: Impact on Pathologic Conditions, Drug Interactions and Drug Design.
Rekka EA, Kourounakis PN, Pantelidou M. Rekka EA, et al. Curr Top Med Chem. 2019;19(4):276-291. doi: 10.2174/1568026619666190129122727. Curr Top Med Chem. 2019. PMID: 30706817 Review.
BACKGROUND: The biotransformation of xenobiotics is a homeostatic defensive response of the body against bioactive invaders. ...The cytochrome P450 superfamily of enzymes plays a major role in the biotransformation of most xenobiotics as well as in the metabolism of …
BACKGROUND: The biotransformation of xenobiotics is a homeostatic defensive response of the body against bioactive invaders. ...The c …
26,185 results
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