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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 4
2001 2
2002 1
2003 2
2005 4
2006 6
2007 1
2008 9
2009 9
2010 3
2011 8
2012 13
2013 9
2014 20
2015 13
2016 34
2017 50
2018 59
2019 79
2020 70
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351 results
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Page 1
Leaky gut and autoimmune diseases.
Fasano A. Fasano A. Clin Rev Allergy Immunol. 2012 Feb;42(1):71-8. doi: 10.1007/s12016-011-8291-x. Clin Rev Allergy Immunol. 2012. PMID: 22109896 Review.
Zonulin is the only physiologic modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the zonulin pathway is deregulated in genetically susceptible ind
Zonulin is the only physiologic modulator of intercellular tight junctions described so far that is involved in trafficking of macrom
Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer.
Fasano A. Fasano A. Physiol Rev. 2011 Jan;91(1):151-75. doi: 10.1152/physrev.00003.2008. Physiol Rev. 2011. PMID: 21248165 Free article. Review.
Zonulin is the only physiological modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the finely tuned zonulin pathway is deregulated in genetically
Zonulin is the only physiological modulator of intercellular tight junctions described so far that is involved in trafficking of macr
Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases.
Sturgeon C, Fasano A. Sturgeon C, et al. Tissue Barriers. 2016 Oct 21;4(4):e1251384. doi: 10.1080/21688370.2016.1251384. eCollection 2016. Tissue Barriers. 2016. PMID: 28123927 Free PMC article. Review.
Additional insights on zonulin mechanism of action and the recent appreciation of the role that altered intestinal permeability can play in the development and progression of chronic inflammatory disorders has increased interest of both basic scientists and clinicians on t …
Additional insights on zonulin mechanism of action and the recent appreciation of the role that altered intestinal permeability can p …
Serum zonulin in patients with inflammatory bowel disease: a pilot study.
Caviglia GP, Dughera F, Ribaldone DG, Rosso C, Abate ML, Pellicano R, Bresso F, Smedile A, Saracco GM, Astegiano M. Caviglia GP, et al. Minerva Med. 2019 Apr;110(2):95-100. doi: 10.23736/S0026-4806.18.05787-7. Epub 2018 Aug 28. Minerva Med. 2019. PMID: 30160088 Free article.
Since zonulin has been proposed as a biomarker of intestinal permeability, we investigated its role in patients with IBD and the correlation between serum and fecal zonulin. ...CONCLUSIONS: Serum zonulin is highly sensitive for the evaluation of intestinal pe …
Since zonulin has been proposed as a biomarker of intestinal permeability, we investigated its role in patients with IBD and the corr …
Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines.
Drago S, El Asmar R, Di Pierro M, Grazia Clemente M, Tripathi A, Sapone A, Thakar M, Iacono G, Carroccio A, D'Agate C, Not T, Zampini L, Catassi C, Fasano A. Drago S, et al. Scand J Gastroenterol. 2006 Apr;41(4):408-19. doi: 10.1080/00365520500235334. Scand J Gastroenterol. 2006. PMID: 16635908
We investigated whether gliadin has any immediate effect on zonulin release and signaling. MATERIAL AND METHODS: Both ex vivo human small intestines and intestinal cell monolayers were exposed to gliadin, and zonulin release and changes in paracellular permeability …
We investigated whether gliadin has any immediate effect on zonulin release and signaling. MATERIAL AND METHODS: Both ex vivo human s …
Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis.
Ciccia F, Guggino G, Rizzo A, Alessandro R, Luchetti MM, Milling S, Saieva L, Cypers H, Stampone T, Di Benedetto P, Gabrielli A, Fasano A, Elewaut D, Triolo G. Ciccia F, et al. Ann Rheum Dis. 2017 Jun;76(6):1123-1132. doi: 10.1136/annrheumdis-2016-210000. Epub 2017 Jan 9. Ann Rheum Dis. 2017. PMID: 28069576 Free PMC article.
Impairment of the gut vascular barrier (GVB) was also present in AS, accompanied by significant upregulation of zonulin, and associated with high serum levels of LPS, LPS-BP, iFABP and zonulin. ...Bacterial products and zonulin influence monocyte behaviour... …
Impairment of the gut vascular barrier (GVB) was also present in AS, accompanied by significant upregulation of zonulin, and associat …
Gut microbiota, dietary intakes and intestinal permeability reflected by serum zonulin in women.
Mörkl S, Lackner S, Meinitzer A, Mangge H, Lehofer M, Halwachs B, Gorkiewicz G, Kashofer K, Painold A, Holl AK, Bengesser SA, Müller W, Holzer P, Holasek SJ. Mörkl S, et al. Eur J Nutr. 2018 Dec;57(8):2985-2997. doi: 10.1007/s00394-018-1784-0. Epub 2018 Jul 24. Eur J Nutr. 2018. PMID: 30043185 Free PMC article.
Zonulin was measured with ELISA. Nutrient intake was assessed by repeated 24-h dietary recalls. We used the median of serum zonulin concentration to divide our participants into a "high-zonulin" (> 53.64 ng/ml) and "low-zonulin" (< 53.64 ng/ml) g
Zonulin was measured with ELISA. Nutrient intake was assessed by repeated 24-h dietary recalls. We used the median of serum zonuli
Zonulin, regulation of tight junctions, and autoimmune diseases.
Fasano A. Fasano A. Ann N Y Acad Sci. 2012 Jul;1258(1):25-33. doi: 10.1111/j.1749-6632.2012.06538.x. Ann N Y Acad Sci. 2012. PMID: 22731712 Free PMC article. Review.
Our discovery of zonulin, the only known physiologic modulator of intercellular TJs described so far, has increased our understanding of the intricate mechanisms that regulate the intestinal epithelial paracellular pathway and has led us to appreciate that its upregulation …
Our discovery of zonulin, the only known physiologic modulator of intercellular TJs described so far, has increased our understanding …
Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression.
Stevens BR, Goel R, Seungbum K, Richards EM, Holbert RC, Pepine CJ, Raizada MK. Stevens BR, et al. Gut. 2018 Aug;67(8):1555-1557. doi: 10.1136/gutjnl-2017-314759. Epub 2017 Aug 16. Gut. 2018. PMID: 28814485 Free PMC article. No abstract available.
IFN-γ, IL-17A, or zonulin rapidly increase the permeability of the blood-brain and small intestinal epithelial barriers: Relevance for neuro-inflammatory diseases.
Rahman MT, Ghosh C, Hossain M, Linfield D, Rezaee F, Janigro D, Marchi N, van Boxel-Dezaire AHH. Rahman MT, et al. Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):274-279. doi: 10.1016/j.bbrc.2018.11.021. Epub 2018 Nov 16. Biochem Biophys Res Commun. 2018. PMID: 30449598
Zonulin, a protein produced by small intestine epithelium, can rapidly increase small intestinal permeability. Zonulin blood levels are elevated in MS, but it is unknown whether zonulin can also disrupt the BBB. ...We here report that primary human brain micr
Zonulin, a protein produced by small intestine epithelium, can rapidly increase small intestinal permeability. Zonulin blood l
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