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2001 1
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Page 1
A roadmap to multifactor dimensionality reduction methods.
Gola D, Mahachie John JM, van Steen K, König IR. Gola D, et al. Brief Bioinform. 2016 Mar;17(2):293-308. doi: 10.1093/bib/bbv038. Epub 2015 Jun 24. Brief Bioinform. 2016. PMID: 26108231 Free PMC article. Review.
From this latter family, a fast-growing collection of methods emerged that are based on the Multifactor Dimensionality Reduction (MDR) approach. Since its first introduction, MDR has enjoyed great popularity in applications and has been extended and modified …
From this latter family, a fast-growing collection of methods emerged that are based on the Multifactor Dimensionality Redu
Epistasis, complexity, and multifactor dimensionality reduction.
Pan Q, Hu T, Moore JH. Pan Q, et al. Methods Mol Biol. 2013;1019:465-77. doi: 10.1007/978-1-62703-447-0_22. Methods Mol Biol. 2013. PMID: 23756906 Review.
We review here computational approaches to genetic analysis that embrace, rather than ignore, the complexity of human health. We focus on multifactor dimensionality reduction (MDR) as an approach for modeling one of these complexities: epistasis or gene-gene …
We review here computational approaches to genetic analysis that embrace, rather than ignore, the complexity of human health. We focus on …
Fuzzy-Based Multiobjective Multifactor Dimensionality Reduction for Epistasis Analysis.
Yang CH, Huang HC, Hou MF, Chuang LY, Lin YD. Yang CH, et al. IEEE/ACM Trans Comput Biol Bioinform. 2023 Jan-Feb;20(1):378-387. doi: 10.1109/TCBB.2022.3144303. Epub 2023 Feb 3. IEEE/ACM Trans Comput Biol Bioinform. 2023. PMID: 35061588
Epistasis detection is vital for understanding disease susceptibility in genetics. Multiobjective multifactor dimensionality reduction (MOMDR) was previously proposed to detect epistasis. ...
Epistasis detection is vital for understanding disease susceptibility in genetics. Multiobjective multifactor dimensionality
Combinatorial pharmacogenetics.
Wilke RA, Reif DM, Moore JH. Wilke RA, et al. Nat Rev Drug Discov. 2005 Nov;4(11):911-8. doi: 10.1038/nrd1874. Nat Rev Drug Discov. 2005. PMID: 16264434 Review.
The high-dimensionality of the resulting analysis problem will often overwhelm traditional analysis methods. Novel analysis techniques, such as multifactor dimensionality reduction, offer viable options for evaluating such data....
The high-dimensionality of the resulting analysis problem will often overwhelm traditional analysis methods. Novel analysis techniques, such …
Exhaustive Variant Interaction Analysis using Multifactor Dimensionality Reduction.
Gómez-Sánchez G, Alonso L, Pérez MÁ, Morán I, Torrents D, Berral JL. Gómez-Sánchez G, et al. Res Sq [Preprint]. 2023 Oct 16:rs.3.rs-3401025. doi: 10.21203/rs.3.rs-3401025/v1. Res Sq. 2023. PMID: 37886566 Free PMC article. Preprint.
As a result, we have created a containerized framework that uses Multifactor Dimensionality Reduction to detect pairs of variants associated with Type 2 Diabetes (T2D). ...
As a result, we have created a containerized framework that uses Multifactor Dimensionality Reduction to detect pairs o …
Epistasis analysis using multifactor dimensionality reduction.
Moore JH, Andrews PC. Moore JH, et al. Methods Mol Biol. 2015;1253:301-14. doi: 10.1007/978-1-4939-2155-3_16. Methods Mol Biol. 2015. PMID: 25403539
Here we introduce the multifactor dimensionality reduction (MDR) methodology and software package for detecting and characterizing epistasis in genetic association studies. ...
Here we introduce the multifactor dimensionality reduction (MDR) methodology and software package for detecting and cha …
Gene-gene interaction: the curse of dimensionality.
Chattopadhyay A, Lu TP. Chattopadhyay A, et al. Ann Transl Med. 2019 Dec;7(24):813. doi: 10.21037/atm.2019.12.87. Ann Transl Med. 2019. PMID: 32042829 Free PMC article. Review.
The dimensionality involved in the epistatic analysis of such exponentially growing SNPs diminishes the usefulness of traditional, parametric statistical methods. With the immense popularity of multifactor dimensionality reduction (MDR), a non-parametric meth …
The dimensionality involved in the epistatic analysis of such exponentially growing SNPs diminishes the usefulness of traditional, parametri …
Multifactor dimensionality reduction reveals the effect of interaction between ERAP1 and IFIH1 polymorphisms in psoriasis susceptibility genes.
Zhang C, Qin Q, Li Y, Zheng X, Chen W, Zhen Q, Li B, Wang W, Sun L. Zhang C, et al. Front Genet. 2022 Nov 8;13:1009589. doi: 10.3389/fgene.2022.1009589. eCollection 2022. Front Genet. 2022. PMID: 36425068 Free PMC article.
Methods: We validated psoriasis susceptibility gene variants in an independent cohort of 5,414 patients with psoriasis and 5,556 controls. Multifactor dimensionality reduction (MDR) analysis was performed to identify the interaction between variants significa …
Methods: We validated psoriasis susceptibility gene variants in an independent cohort of 5,414 patients with psoriasis and 5,556 controls. …
An improved fuzzy set-based multifactor dimensionality reduction for detecting epistasis.
Yang CH, Chuang LY, Lin YD. Yang CH, et al. Artif Intell Med. 2020 Jan;102:101768. doi: 10.1016/j.artmed.2019.101768. Epub 2019 Nov 22. Artif Intell Med. 2020. PMID: 31980105
The rapid development of technology has enabled scalability to make multifactor dimensionality reduction (MDR) measurements an effective calculation tool that achieves superior detection. ...
The rapid development of technology has enabled scalability to make multifactor dimensionality reduction (MDR) measurem …
1,352 results