Interleukin 2 with anti-GD2 antibody ch14.18/CHO (dinutuximab beta) in patients with high-risk neuroblastoma (HR-NBL1/SIOPEN): a multicentre, randomised, phase 3 trial.
Lancet Oncol. 2018 Dec;19(12):1617-1629. doi: 10.1016/S1470-2045(18)30578-3. Epub 2018 Nov 12.
Lancet Oncol. 2018.
PMID: 30442501
Clinical Trial.
In this component of the trial, patients were randomly assigned (1:1) to receive dinutuximab beta (20 mg/m(2) per day as an 8 h infusion for 5 consecutive days) or dinutuximab beta plus subcutaneous IL-2 (6 10(6) IU/m(2) per day on days 1-5 and days 8-12 of each cycle) wit …
In this component of the trial, patients were randomly assigned (1:1) to receive dinutuximab beta (20 mg/m(2) per day as an 8 h infusion …