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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1974 3
1975 12
1976 14
1977 17
1978 41
1979 46
1980 38
1981 27
1982 39
1983 66
1984 57
1985 73
1986 73
1987 69
1988 72
1989 70
1990 77
1991 81
1992 67
1993 63
1994 52
1995 61
1996 62
1997 84
1998 82
1999 71
2000 76
2001 95
2002 82
2003 93
2004 92
2005 111
2006 113
2007 130
2008 128
2009 119
2010 146
2011 160
2012 177
2013 191
2014 187
2015 235
2016 265
2017 288
2018 330
2019 355
2020 415
2021 431
2022 486
2023 57
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5,609 results
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Page 1
Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity.
Koleini N, Kardami E. Koleini N, et al. Oncotarget. 2017 Jul 11;8(28):46663-46680. doi: 10.18632/oncotarget.16944. Oncotarget. 2017. PMID: 28445146 Free PMC article. Review.
Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols. ...Here we will review Dox-induced cardiotoxicity and cell death in the broad context of the autophagy and mitophagy processes....
Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols. ...Here we will review Dox-induced ca …
Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management.
Rawat PS, Jaiswal A, Khurana A, Bhatti JS, Navik U. Rawat PS, et al. Biomed Pharmacother. 2021 Jul;139:111708. doi: 10.1016/j.biopha.2021.111708. Epub 2021 May 13. Biomed Pharmacother. 2021. PMID: 34243633 Free article. Review.
Doxorubicin (Dox) is a secondary metabolite of the mutated strain of Streptomyces peucetius var. ...There are several mechanisms has been proposed for doxorubicin-induced cardiotoxicity and oxidative stress, free radical generation and apoptosis are most wide …
Doxorubicin (Dox) is a secondary metabolite of the mutated strain of Streptomyces peucetius var. ...There are several mechanisms has …
Regulated cell death pathways in doxorubicin-induced cardiotoxicity.
Christidi E, Brunham LR. Christidi E, et al. Cell Death Dis. 2021 Apr 1;12(4):339. doi: 10.1038/s41419-021-03614-x. Cell Death Dis. 2021. PMID: 33795647 Free PMC article. Review.
Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug. ...Understanding the mechanisms by which doxorubicin leads to cardiom …
Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxi …
Doxorubicin-induced cardiotoxicity: causative factors and possible interventions.
Jones IC, Dass CR. Jones IC, et al. J Pharm Pharmacol. 2022 Nov 25;74(12):1677-1688. doi: 10.1093/jpp/rgac063. J Pharm Pharmacol. 2022. PMID: 35994421 Review.
A large amount of current research is on reducing Dox-induced cardiotoxicity by developing targeted delivery systems and investigating cardiotoxicity mechanisms. Recently, discrepancies have challenged the traditional understanding of Dox metabolism, mechanisms of a …
A large amount of current research is on reducing Dox-induced cardiotoxicity by developing targeted delivery systems and investigatin …
Underlying the Mechanisms of Doxorubicin-Induced Acute Cardiotoxicity: Oxidative Stress and Cell Death.
Kong CY, Guo Z, Song P, Zhang X, Yuan YP, Teng T, Yan L, Tang QZ. Kong CY, et al. Int J Biol Sci. 2022 Jan 1;18(2):760-770. doi: 10.7150/ijbs.65258. eCollection 2022. Int J Biol Sci. 2022. PMID: 35002523 Free PMC article. Review.
Cancer is a destructive disease that causes high levels of morbidity and mortality. Doxorubicin (DOX) is a highly efficient antineoplastic chemotherapeutic drug, but its use places survivors at risk for cardiotoxicity. ...Hence, we attempt to explain the cellular me …
Cancer is a destructive disease that causes high levels of morbidity and mortality. Doxorubicin (DOX) is a highly efficient antineopl …
ADAR2 increases in exercised heart and protects against myocardial infarction and doxorubicin-induced cardiotoxicity.
Wu X, Wang L, Wang K, Li J, Chen R, Wu X, Ni G, Liu C, Das S, Sluijter JPG, Li X, Xiao J. Wu X, et al. Mol Ther. 2022 Jan 5;30(1):400-414. doi: 10.1016/j.ymthe.2021.07.004. Epub 2021 Jul 16. Mol Ther. 2022. PMID: 34274534 Free PMC article.
AAV9-mediated cardiac-specific ADAR2 overexpression attenuated acute myocardial infarction (AMI), MI remodeling, and doxorubicin (DOX)-induced cardiotoxicity. In vitro, overexpression of ADAR2 inhibited DOX-induced cardiomyocyte (CM) apoptosis. but it could also ind …
AAV9-mediated cardiac-specific ADAR2 overexpression attenuated acute myocardial infarction (AMI), MI remodeling, and doxorubicin (DOX …
Identification of Drug Transporter Genomic Variants and Inhibitors That Protect Against Doxorubicin-Induced Cardiotoxicity.
Magdy T, Jouni M, Kuo HH, Weddle CJ, Lyra-Leite D, Fonoudi H, Romero-Tejeda M, Gharib M, Javed H, Fajardo G, Ross CJD, Carleton BC, Bernstein D, Burridge PW. Magdy T, et al. Circulation. 2022 Jan 25;145(4):279-294. doi: 10.1161/CIRCULATIONAHA.121.055801. Epub 2021 Dec 7. Circulation. 2022. PMID: 34874743 Free PMC article.
BACKGROUND: Multiple pharmacogenomic studies have identified the synonymous genomic variant rs7853758 (G > A, L461L) and the intronic variant rs885004 in SLC28A3 (solute carrier family 28 member 3) as statistically associated with a lower incidence of anthracycline-induced …
BACKGROUND: Multiple pharmacogenomic studies have identified the synonymous genomic variant rs7853758 (G > A, L461L) and the intronic var …
Oxidative stress injury in doxorubicin-induced cardiotoxicity.
Songbo M, Lang H, Xinyong C, Bin X, Ping Z, Liang S. Songbo M, et al. Toxicol Lett. 2019 Jun 1;307:41-48. doi: 10.1016/j.toxlet.2019.02.013. Epub 2019 Feb 25. Toxicol Lett. 2019. PMID: 30817977 Review.
Doxorubicin (DOX) is widely used as a broad-spectrum anti-tumor anthracycline to treat various cancers. The serious adverse effects of DOX on cardiotoxicity limit its clinical application. There are several different mechanisms involved in DOX-induced cardiotoxic …
Doxorubicin (DOX) is widely used as a broad-spectrum anti-tumor anthracycline to treat various cancers. The serious adverse effects o …
Exercise intervention decreases acute and late doxorubicin-induced cardiotoxicity.
Wang F, Chandra J, Kleinerman ES. Wang F, et al. Cancer Med. 2021 Nov;10(21):7572-7584. doi: 10.1002/cam4.4283. Epub 2021 Sep 15. Cancer Med. 2021. PMID: 34523825 Free PMC article.
BACKGROUND: Doxorubicin (Dox) is one of the most effective chemotherapy agents used to treat adolescent and young adult sarcoma patients. Unfortunately, Dox causes cardiotoxicities that compromise long-term survival. We investigated whether exercise prevented car …
BACKGROUND: Doxorubicin (Dox) is one of the most effective chemotherapy agents used to treat adolescent and young adult sarcoma patie …
Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway.
Hu C, Zhang X, Song P, Yuan YP, Kong CY, Wu HM, Xu SC, Ma ZG, Tang QZ. Hu C, et al. Redox Biol. 2020 Oct;37:101747. doi: 10.1016/j.redox.2020.101747. Epub 2020 Oct 7. Redox Biol. 2020. PMID: 33045622 Free PMC article.
Herein, we aim to investigate the potential role and molecular basis of METRNL in doxorubicin (DOX)-induced cardiotoxicity. METRNL was found to be abundantly expressed in cardiac muscle under physiological conditions that was decreased upon DOX exposure. ...Targetin …
Herein, we aim to investigate the potential role and molecular basis of METRNL in doxorubicin (DOX)-induced cardiotoxicity. ME …
5,609 results