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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1961 1
1967 3
1973 3
1974 2
1975 2
1976 4
1977 1
1978 2
1979 3
1980 4
1981 4
1982 5
1983 1
1984 5
1985 4
1986 5
1987 1
1988 2
1989 1
1990 3
1991 2
1992 2
1993 2
1995 3
1996 3
1997 4
1998 4
1999 6
2000 6
2001 5
2002 11
2003 10
2004 5
2005 5
2006 7
2007 11
2008 16
2009 11
2010 10
2011 16
2012 7
2013 16
2014 12
2015 9
2016 6
2017 14
2018 14
2019 18
2020 17
2021 17
2022 25
2023 6
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329 results
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Page 1
Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence.
Zheng H, Liang X, Han Q, Shao Z, Zhang Y, Shi L, Hong Y, Li W, Mai C, Mo Q, Fu Q, Ma X, Lin F, Li M, Hu B, Li X, Zhang Y. Zheng H, et al. J Nanobiotechnology. 2021 Oct 21;19(1):332. doi: 10.1186/s12951-021-01077-y. J Nanobiotechnology. 2021. PMID: 34674708 Free PMC article.
METHODS: MSC-EXO and Hemin-MSC-EXO were collected and characterized. MSC-EXO and Hemin-MSC-EXO were intramuscularly injected into the peri-infarct region in a mouse model of MI. ...Compared with MSC-EXO, injection of Hemin-MSC-EXO significantly …
METHODS: MSC-EXO and Hemin-MSC-EXO were collected and characterized. MSC-EXO and Hemin-MSC-EXO were intramuscularly injecte
Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria.
Balwani M, Sardh E, Ventura P, Peiró PA, Rees DC, Stölzel U, Bissell DM, Bonkovsky HL, Windyga J, Anderson KE, Parker C, Silver SM, Keel SB, Wang JD, Stein PE, Harper P, Vassiliou D, Wang B, Phillips J, Ivanova A, Langendonk JG, Kauppinen R, Minder E, Horie Y, Penz C, Chen J, Liu S, Ko JJ, Sweetser MT, Garg P, Vaishnaw A, Kim JB, Simon AR, Gouya L; ENVISION Investigators. Balwani M, et al. N Engl J Med. 2020 Jun 11;382(24):2289-2301. doi: 10.1056/NEJMoa1913147. N Engl J Med. 2020. PMID: 32521132 Clinical Trial.
(Composite porphyria attacks resulted in hospitalization, an urgent health care visit, or intravenous administration of hemin at home.) Key secondary end points were levels of ALA and porphobilinogen and the annualized attack rate among patients with acute hepatic porphyri …
(Composite porphyria attacks resulted in hospitalization, an urgent health care visit, or intravenous administration of hemin at home …
Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling.
Yu H, Cao X, Li W, Liu P, Zhao Y, Song L, Chen J, Chen B, Yu W, Xu Y. Yu H, et al. J Neuroinflammation. 2020 Oct 28;17(1):322. doi: 10.1186/s12974-020-01978-z. J Neuroinflammation. 2020. PMID: 33115476 Free PMC article.
However, the role of excessive Cx43Hc opening in intracerebral hemorrhage (ICH) injury is not clear. METHODS: Hemin stimulation in primary cells and collagenase IV injection in C57BL/6J (B6) mice were used as ICH models in vitro and in vivo. ...Intriguingly, Cx43 tr …
However, the role of excessive Cx43Hc opening in intracerebral hemorrhage (ICH) injury is not clear. METHODS: Hemin stimulation in pr …
Peptide nanotube/hemin composite with enhanced peroxidase activity for the detection of dopamine in food and drug samples.
Mei X, Wang Y, Li F, Yang R, Zhao Y, Yang X. Mei X, et al. Methods. 2022 Dec;208:28-34. doi: 10.1016/j.ymeth.2022.10.007. Epub 2022 Oct 28. Methods. 2022. PMID: 36330923
Inspired by natural enzymes, artificial enzymes have been widely studied due to their ease of mass production, robustness to harsh environments and high stability. In this work, a peptide nanotube/hemin composite (KL@hemin) as an artificial enzyme was prepared by im …
Inspired by natural enzymes, artificial enzymes have been widely studied due to their ease of mass production, robustness to harsh environme …
Ferroptosis in oligodendrocyte progenitor cells mediates white matter injury after hemorrhagic stroke.
Shen D, Wu W, Liu J, Lan T, Xiao Z, Gai K, Hu L, Luo Z, Wei C, Wang X, Lu Y, Wang Y, Zhang C, Wang P, Zuo Z, Yang F, Li Q. Shen D, et al. Cell Death Dis. 2022 Mar 23;13(3):259. doi: 10.1038/s41419-022-04712-0. Cell Death Dis. 2022. PMID: 35318305 Free PMC article.
However, how to prevent the cell death of OPCs is still poorly understood, especially in hemorrhagic diseases. In the current study, we injected autologous blood into the mouse lateral ventricular to study the hemorrhage-induced OPC cell death in vivo. ...In addition, we f …
However, how to prevent the cell death of OPCs is still poorly understood, especially in hemorrhagic diseases. In the current study, we i
Cu-Hemin Nanosheets and Indocyanine Green Co-Loaded Hydrogel for Photothermal Therapy and Amplified Photodynamic Therapy.
Zhu S, Wang S, Liu C, Lyu M, Huang Q. Zhu S, et al. Front Oncol. 2022 Jun 30;12:918416. doi: 10.3389/fonc.2022.918416. eCollection 2022. Front Oncol. 2022. PMID: 35847901 Free PMC article.
However, the high content of GSH in the tumor microenvironment (TME) limited the further therapeutic performance of ICG. Herein, injectable agarose in situ forming NIR-responsive hydrogels (CIH) incorporating Cu-Hemin and ICG were prepared for the first time. When C …
However, the high content of GSH in the tumor microenvironment (TME) limited the further therapeutic performance of ICG. Herein, injectab
Hemin-lipid assembly as an artemisinin oral delivery system for enhanced cancer chemotherapy and immunotherapy.
Wang Q , Wei N , Guo J , Feng K , Wong YK , Zhang J , Wang J , Sun X . Wang Q , et al. Nanoscale. 2021 Aug 21;13(31):13231-13240. doi: 10.1039/d1nr01302e. Epub 2021 Jul 22. Nanoscale. 2021. PMID: 34477731
Considering the important role of heme in the specific parasite-killing effect of ART, we designed a liposomal nanostructure self-assembled from hemin-lipid (Hemesome) to co-deliver ART and hemin for cancer therapy. The synergistic chemotherapeutic and immunotherape …
Considering the important role of heme in the specific parasite-killing effect of ART, we designed a liposomal nanostructure self-assembled …
Deferoxamine therapy reduces brain hemin accumulation after intracerebral hemorrhage in piglets.
Hu S, Hua Y, Keep RF, Feng H, Xi G. Hu S, et al. Exp Neurol. 2019 Aug;318:244-250. doi: 10.1016/j.expneurol.2019.05.003. Epub 2019 May 10. Exp Neurol. 2019. PMID: 31078524 Free PMC article. Review.
The effect of deferoxamine (DFX) on hemin-Hpx-CD91 was also examined. The study consisted of two parts. ...DFX treatment decreased hemin release from the hematoma and reduced the expression of Hpx and CD91....
The effect of deferoxamine (DFX) on hemin-Hpx-CD91 was also examined. The study consisted of two parts. ...DFX treatment decreased …
Hemin-incorporating DNA nanozyme enabling catalytic oxygenation and GSH depletion for enhanced photodynamic therapy and synergistic tumor ferroptosis.
Xiao X, Chen M, Zhang Y, Li L, Peng Y, Li J, Zhou W. Xiao X, et al. J Nanobiotechnology. 2022 Sep 15;20(1):410. doi: 10.1186/s12951-022-01617-0. J Nanobiotechnology. 2022. PMID: 36109814 Free PMC article.
The DNA nanozyme was constructed via rolling circle amplification, which contained repeat AS1411 G quadruplex (G4) units to form multiple G4/hemin DNAzymes with catalase-mimic activity. Both hemin, an iron-containing porphyrin cofactor, and chlorine e6 (Ce6), a phot …
The DNA nanozyme was constructed via rolling circle amplification, which contained repeat AS1411 G quadruplex (G4) units to form multiple G4 …
Hemin mitigates contrast-induced nephropathy by inhibiting ferroptosis via HO-1/Nrf2/GPX4 pathway.
Gao Z, Zhang Z, Gu D, Li Y, Zhang K, Dong X, Liu L, Zhang J, Chen J, Wu D, Zeng M. Gao Z, et al. Clin Exp Pharmacol Physiol. 2022 Aug;49(8):858-870. doi: 10.1111/1440-1681.13673. Epub 2022 Jun 10. Clin Exp Pharmacol Physiol. 2022. PMID: 35598290
Hemin, a HO-1 inducer and anti-porphyria medicine, may have a promising effect against CIN. ...HK-2 cells insulted by iopromide demonstrated decreased cell vitality and rising reactive oxygen species (ROS), which could also be inhibited by hemin. The effects of h
Hemin, a HO-1 inducer and anti-porphyria medicine, may have a promising effect against CIN. ...HK-2 cells insulted by iopromide demon
329 results