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94 results
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Page 1
Opioids.
[No authors listed] [No authors listed] 2020 Nov 24. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2020 Nov 24. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31643200 Free Books & Documents. Review.
The natural alkaloids are also referred to as opiates and include morphine and codeine. Synthetic derivatives include heroin, fentanyl, hydromorphone, methadone, buprenorphine and others. The opioids are highly potent and effective analgesics, but most have a high poten …
The natural alkaloids are also referred to as opiates and include morphine and codeine. Synthetic derivatives include heroin, fentanyl, h …
Pharmacokinetics and Abuse Potential of Asalhydromorphone, a Novel Prodrug of Hydromorphone, After Intranasal Administration in Recreational Drug Users.
Guenther S, Mickle TC, Barrett AC, Smith A, Braeckman R, Kelsh D, Vince B. Guenther S, et al. Pain Med. 2020 Mar 1;21(3):511-520. doi: 10.1093/pm/pnz066. Pain Med. 2020. PMID: 30986302 Clinical Trial.
A prodrug of hydromorphone, asalhydromorphone (ASAL-HM), has been designed to deter nonoral forms of abuse associated with hydromorphone. ...CONCLUSIONS: The novel hydromorphone prodrug ASAL-HM produced marked reductions in hydromorphone exposur …
A prodrug of hydromorphone, asalhydromorphone (ASAL-HM), has been designed to deter nonoral forms of abuse associated with …
Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone).
Pergolizzi J, Böger RH, Budd K, Dahan A, Erdine S, Hans G, Kress HG, Langford R, Likar R, Raffa RB, Sacerdote P. Pergolizzi J, et al. Pain Pract. 2008 Jul-Aug;8(4):287-313. doi: 10.1111/j.1533-2500.2008.00204.x. Epub 2008 May 23. Pain Pract. 2008. PMID: 18503626
The use of opioids in cancer pain: The criteria for selecting analgesics for pain treatment in the elderly include, but are not limited to, overall efficacy, overall side-effect profile, onset of action, drug interactions, abuse potential, and practical issues, such …
The use of opioids in cancer pain: The criteria for selecting analgesics for pain treatment in the elderly include, but are not limited to, …
Opioid Management in CKD.
Lu E, Schell JO, Koncicki HM. Lu E, et al. Am J Kidney Dis. 2021 May;77(5):786-795. doi: 10.1053/j.ajkd.2020.08.018. Epub 2020 Oct 22. Am J Kidney Dis. 2021. PMID: 33500128 Review.
Concurrently, opioid prescription and use in patients with CKD continues to increase, leading to concern for opioid-related risks. Nephrologists increasingly face challenging clinical situations requiring further evaluation and treatment of pain, for which opioid use may b …
Concurrently, opioid prescription and use in patients with CKD continues to increase, leading to concern for opioid-related risks. Ne …
Prescription of Controlled Substances: Benefits and Risks.
Preuss CV, Kalava A, King KC. Preuss CV, et al. 2022 Sep 21. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. 2022 Sep 21. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 30726003 Free Books & Documents.
Controlled substances have a high risk of resulting in addiction and substance use disorder. As the schedules decrease, I-V, the drugs listed within each category have a lower potential to cause a substance use or addiction disorder. Controlled Substance …
Controlled substances have a high risk of resulting in addiction and substance use disorder. As the schedules decrease, I-V, the drug …
Hydromorphone use for acute pain: Misconceptions, controversies, and risks.
Mazer-Amirshahi M, Motov S, Nelson LS. Mazer-Amirshahi M, et al. J Opioid Manag. 2018 Jan/Feb;14(1):61-71. doi: 10.5055/jom.2018.0430. J Opioid Manag. 2018. PMID: 29508897 Review.
Hydromorphone (HM) is a potent opioid analgesic that is commonly administered in the emergency department (ED) and other acute care settings, such as medical surgical wards. ...In addition, intravenous HM has potent euphoric effects that may contribute to its abuse …
Hydromorphone (HM) is a potent opioid analgesic that is commonly administered in the emergency department (ED) and other acute care s …
In vitro and in vivo assessment of the abuse potential of PF614, a novel BIO-MD™ prodrug of oxycodone.
Kirkpatrick DL, Schmidt WK, Morales R, Cremin J, Seroogy J, Husfeld C, Jenkins T. Kirkpatrick DL, et al. J Opioid Manag. 2017 Jan/Feb;13(1):39-49. doi: 10.5055/jom.2017.0366. J Opioid Manag. 2017. PMID: 28345745
OBJECTIVE: The need for pain medication which will not lead to abuse is well recognized. Ensysce has designed prodrug analogs of the commonly used pain medications including hydromorphone, oxycodone (OC), hydrocodone, and morphine that limit their use to oral delive …
OBJECTIVE: The need for pain medication which will not lead to abuse is well recognized. Ensysce has designed prodrug analogs of the …
Evaluation of the abuse potential of extended release hydromorphone versus immediate release hydromorphone.
Shram MJ, Sathyan G, Khanna S, Tudor IC, Nath R, Thipphawong J, Sellers EM. Shram MJ, et al. J Clin Psychopharmacol. 2010 Feb;30(1):25-33. doi: 10.1097/JCP.0b013e3181c8f088. J Clin Psychopharmacol. 2010. PMID: 20075644 Clinical Trial.
In this double-blind, placebo-controlled, randomized, 2-part crossover study, the abuse potential of single oral doses of hydromorphone ER (intact: 16-, 32-, and 64-mg; milled: 8-mg) was compared with 8-mg hydromorphone IR and placebo. ...Delayed onset …
In this double-blind, placebo-controlled, randomized, 2-part crossover study, the abuse potential of single oral doses of h …
The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers.
Walsh SL, Nuzzo PA, Lofwall MR, Holtman JR Jr. Walsh SL, et al. Drug Alcohol Depend. 2008 Dec 1;98(3):191-202. doi: 10.1016/j.drugalcdep.2008.05.007. Epub 2008 Jul 7. Drug Alcohol Depend. 2008. PMID: 18606504 Free PMC article. Clinical Trial.
Few controlled comparisons of the abuse liability of the most commonly abused opioids have been conducted. This outpatient study employed a double-blind, randomized, within-subject, placebo-controlled design to examine the relative abuse potential and …
Few controlled comparisons of the abuse liability of the most commonly abused opioids have been conducted. This outpatient stu …
Within-subject, double-blinded, randomized, and placebo-controlled evaluation of the combined effects of the cannabinoid dronabinol and the opioid hydromorphone in a human laboratory pain model.
Dunn KE, Bergeria CL, Huhn AS, Speed TJ, Mun CJ, Vandrey R, Campbell CM. Dunn KE, et al. Neuropsychopharmacology. 2021 Jul;46(8):1451-1459. doi: 10.1038/s41386-021-01007-4. Epub 2021 Apr 20. Neuropsychopharmacology. 2021. PMID: 33879842 Free PMC article. Clinical Trial.
Hydromorphone + dronabinol 2.5 mg showed the lowest and hydromorphone+dronabinol 5 mg showed the highest risk for abuse. ...Overall, only hydromorphone+dronabinol 2.5 mg modestly enhanced hydromorphone-based analgesia and hydromorphone + …
Hydromorphone + dronabinol 2.5 mg showed the lowest and hydromorphone+dronabinol 5 mg showed the highest risk for abuse …
94 results