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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 6
1954 46
1955 21
1956 33
1957 27
1958 23
1959 15
1960 44
1961 38
1962 77
1963 125
1964 274
1965 200
1966 191
1967 264
1968 322
1969 486
1970 500
1971 521
1972 536
1973 551
1974 563
1975 422
1976 348
1977 302
1978 294
1979 279
1980 266
1981 264
1982 270
1983 250
1984 331
1985 351
1986 321
1987 455
1988 364
1989 416
1990 357
1991 359
1992 402
1993 401
1994 356
1995 333
1996 385
1997 332
1998 411
1999 337
2000 356
2001 374
2002 345
2003 398
2004 411
2005 415
2006 401
2007 422
2008 441
2009 457
2010 497
2011 482
2012 490
2013 488
2014 461
2015 469
2016 445
2017 448
2018 402
2019 393
2020 430
2021 361
2022 307
2023 26
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22,178 results
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Page 1
Why more 6-mercaptopurine?
Kamen BA. Kamen BA. Semin Hematol. 1991 Jul;28(3 Suppl 4):12-4. Semin Hematol. 1991. PMID: 1780746 Review. No abstract available.
Thioguanine, mercaptopurine: their analogs and nucleosides as antimetabolites.
Elgemeie GH. Elgemeie GH. Curr Pharm Des. 2003;9(31):2627-42. doi: 10.2174/1381612033453677. Curr Pharm Des. 2003. PMID: 14529546 Review.
6-Mercaptopurine (6MP) and 6-thioguanine (6TG) are analogs of the natural purines: hypoxanthine and guanine. ...This review will focus on mercaptopurine analogs and their nucleosides as antimetabolite agents....
6-Mercaptopurine (6MP) and 6-thioguanine (6TG) are analogs of the natural purines: hypoxanthine and guanine. ...This review will focu …
Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease.
Prefontaine E, Macdonald JK, Sutherland LR. Prefontaine E, et al. Cochrane Database Syst Rev. 2010 Jun 16;(6):CD000545. doi: 10.1002/14651858.CD000545.pub3. Cochrane Database Syst Rev. 2010. PMID: 20556747 Updated. Review.
The odds ratio (OR) of a response to azathioprine or 6-mercaptopurine therapy compared with placebo in active Crohn's disease was 2.43 (95% CI 1.62 to 3.64). ...The NNT to observe one adverse event in one patient treated with azathioprine or 6-mercaptopurine was 14. …
The odds ratio (OR) of a response to azathioprine or 6-mercaptopurine therapy compared with placebo in active Crohn's disease was 2.4 …
Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease.
Prefontaine E, Macdonald JK, Sutherland LR. Prefontaine E, et al. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD000545. doi: 10.1002/14651858.CD000545.pub2. Cochrane Database Syst Rev. 2009. PMID: 19821270 Updated. Review.
The odds ratio (OR) of a response to azathioprine or 6-mercaptopurine therapy compared with placebo in active Crohn's disease was 2.43 (95% CI 1.62 to 3.64). ...The NNT to observe one adverse event in one patient treated with azathioprine or 6-mercaptopurine was 14. …
The odds ratio (OR) of a response to azathioprine or 6-mercaptopurine therapy compared with placebo in active Crohn's disease was 2.4 …
The increasing complexity of mercaptopurine pharmacogenomics.
Marsh S, Van Booven DJ. Marsh S, et al. Clin Pharmacol Ther. 2009 Feb;85(2):139-41. doi: 10.1038/clpt.2008.219. Clin Pharmacol Ther. 2009. PMID: 19151640 Review.
Low and intermediate TPMT activity leads to toxicity from mercaptopurine and the need for dose reduction. Common variants in the TPMT gene have a strong association with mercaptopurine toxicity. However, recent research has shown that genetic contribution to merc …
Low and intermediate TPMT activity leads to toxicity from mercaptopurine and the need for dose reduction. Common variants in the TPMT …
Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease.
Chande N, Tsoulis DJ, MacDonald JK. Chande N, et al. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD000545. doi: 10.1002/14651858.CD000545.pub4. Cochrane Database Syst Rev. 2013. PMID: 23633304 Updated. Review.
BACKGROUND: The results from controlled clinical trials investigating the efficacy of azathioprine and 6-mercaptopurine for the treatment of active Crohn's disease have been conflicting and controversial. ...MAIN RESULTS: Thirteen RCTs (n = 1211 patients) of azathioprine a …
BACKGROUND: The results from controlled clinical trials investigating the efficacy of azathioprine and 6-mercaptopurine for the treat …
Azathioprine or 6-mercaptopurine for inducing remission of Crohn's disease.
Sandborn W, Sutherland L, Pearson D, May G, Modigliani R, Prantera C. Sandborn W, et al. Cochrane Database Syst Rev. 2000;(2):CD000545. doi: 10.1002/14651858.CD000545. Cochrane Database Syst Rev. 2000. PMID: 10796557 Updated. Review.
MAIN RESULTS: The odds ratio of a response to azathioprine or 6-mercaptopurine therapy compared with placebo in active Crohn's disease was 2.36 (95% CI 1.57-3.53). ...The number needed to treat to observe one adverse event in one patient treated with azathioprine or 6-m …
MAIN RESULTS: The odds ratio of a response to azathioprine or 6-mercaptopurine therapy compared with placebo in active Crohn's diseas …
A trial of mercaptopurine is a safe strategy in patients with inflammatory bowel disease intolerant to azathioprine: an observational study, systematic review and meta-analysis.
Kennedy NA, Rhatigan E, Arnott ID, Noble CL, Shand AG, Satsangi J, Lees CW. Kennedy NA, et al. Aliment Pharmacol Ther. 2013 Nov;38(10):1255-66. doi: 10.1111/apt.12511. Epub 2013 Oct 5. Aliment Pharmacol Ther. 2013. PMID: 24117596 Free article. Review.
RESULTS: Mercaptopurine was tolerated by 58% of azathioprine-intolerant patients in the Edinburgh cohort. In the meta-analysis, 68% tolerated mercaptopurine. A higher proportion of those in the meta-analysis with GI toxicity (62%) or hepatotoxicity (81%) were able t …
RESULTS: Mercaptopurine was tolerated by 58% of azathioprine-intolerant patients in the Edinburgh cohort. In the meta-analysis, 68% t …
The genetic toxicology of 6-mercaptopurine.
Mosesso P, Palitti F. Mosesso P, et al. Mutat Res. 1993 Mar;296(3):279-94. doi: 10.1016/0165-1110(93)90015-f. Mutat Res. 1993. PMID: 7680107 Review. No abstract available.
22,178 results
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