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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
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1974 4
1975 2
1976 2
1977 1
1980 1
1981 1
1982 1
1984 1
1986 2
1988 2
1989 1
1990 1
1991 1
1995 1
1996 1
1999 1
2000 1
2001 2
2003 1
2004 5
2005 7
2006 5
2007 6
2008 10
2009 4
2010 6
2011 7
2012 14
2013 12
2014 8
2015 3
2016 7
2017 9
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2019 11
2020 11
2021 3
2022 3
2023 1
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151 results
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Page 1
Methadone overdose and cardiac arrhythmia potential: findings from a review of the evidence for an American Pain Society and College on Problems of Drug Dependence clinical practice guideline.
Chou R, Weimer MB, Dana T. Chou R, et al. J Pain. 2014 Apr;15(4):338-65. doi: 10.1016/j.jpain.2014.01.495. J Pain. 2014. PMID: 24685459 Review.
Evidence on cardiac risks is primarily limited to case reports of torsades de pointes, primarily in patients on high doses of methadone, and to studies showing an association between methadone use and prolongation of QTc intervals. Research is needed to under …
Evidence on cardiac risks is primarily limited to case reports of torsades de pointes, primarily in patients on high doses of meth
Methadone and buprenorphine for the management of opioid dependence in pregnancy.
Jones HE, Finnegan LP, Kaltenbach K. Jones HE, et al. Drugs. 2012 Apr 16;72(6):747-57. doi: 10.2165/11632820-000000000-00000. Drugs. 2012. PMID: 22512363 Review.
This article provides an overview and discussion of the collective maternal, fetal and neonatal outcome research on women maintained on methadone or buprenorphine during pregnancy. Its focus is on an assessment of the comparative effectiveness of methadone and bupre …
This article provides an overview and discussion of the collective maternal, fetal and neonatal outcome research on women maintained on m
Identifying Clinically Relevant Drug-Drug Interactions With Methadone and Buprenorphine: A Translational Approach to Signal Detection.
Miano TA, Wang L, Leonard CE, Brensinger CM, Acton EK, Dawwas GK, Bilker WB, Soprano SE, Nguyen TPP, Woody G, Yu E, Neuman M, Li L, Hennessy S. Miano TA, et al. Clin Pharmacol Ther. 2022 Nov;112(5):1120-1129. doi: 10.1002/cpt.2717. Epub 2022 Aug 20. Clin Pharmacol Ther. 2022. PMID: 35881659
Methadone and buprenorphine have pharmacologic properties that are concerning for a high risk of drug-drug interactions (DDIs). ...In SCCS analysis, 1,432 events were included from 248,069 new users of methadone or buprenorphine. In the primary analysis, statistical
Methadone and buprenorphine have pharmacologic properties that are concerning for a high risk of drug-drug interactions (DDIs). ...In
Methadone prolongs cardiac conduction in young patients with cancer-related pain.
Anghelescu DL, Patel RM, Mahoney DP, Trujillo L, Faughnan LG, Steen BD, Baker JN, Pei D. Anghelescu DL, et al. J Opioid Manag. 2016 May-Jun;12(2):131-8. doi: 10.5055/jom.2016.0325. J Opioid Manag. 2016. PMID: 27194198 Free PMC article.
OBJECTIVE: Methadone prolongs cardiac conduction, from mild corrected QT (QTc) prolongation to torsades de pointes and ventricular fibrillation, in adults. However, methadone use for pain and its effects on cardiac conduction have not been investigated …
OBJECTIVE: Methadone prolongs cardiac conduction, from mild corrected QT (QTc) prolongation to torsades de pointes and ventric …
Maternal methadone dosing schedule and fetal neurobehaviour.
Jansson LM, Dipietro JA, Velez M, Elko A, Knauer H, Kivlighan KT. Jansson LM, et al. J Matern Fetal Neonatal Med. 2009 Jan;22(1):29-35. doi: 10.1080/14767050802452291. J Matern Fetal Neonatal Med. 2009. PMID: 19085624 Free PMC article. Clinical Trial.
OBJECTIVE: Daily methadone maintenance is the standard of care for opiate dependency during pregnancy. ...Monitoring sessions occurred at 36- and 37-weeks gestation in a counterbalanced study design. Fetal measures included heart rate, variability, accelerations, mo …
OBJECTIVE: Daily methadone maintenance is the standard of care for opiate dependency during pregnancy. ...Monitoring sessions occurre …
Anaesthetic management and complications of transvascular patent ductus arteriosus occlusion in dogs.
Parisi C, Phillips V, Ferreira J, Linney C, Mair A. Parisi C, et al. Vet Anaesth Analg. 2020 Sep;47(5):581-587. doi: 10.1016/j.vaa.2020.01.009. Epub 2020 Apr 20. Vet Anaesth Analg. 2020. PMID: 32792269

METHODS: Anaesthetic records of dogs with PDA that underwent transvascular occlusion of the ductus were reviewed. Anaesthetic complications evaluated included tachycardia [heart rate (HR) > 160 beats minute(-1)], bradycardia (HR < 50 beats minute(-1)), hyperte

METHODS: Anaesthetic records of dogs with PDA that underwent transvascular occlusion of the ductus were reviewed. Anaesthetic complicatio
Effect of Oral Methadone on ECG Characteristics and Endocrine Hormonal Changes and Their Inter-relationship.
Bonakdaran S, Daloee MH, Manteghi AA, Akbarirad M, Firoozi A, Akbarirad F. Bonakdaran S, et al. Endocr Metab Immune Disord Drug Targets. 2016;16(3):168-173. doi: 10.2174/1871530316666161026142930. Endocr Metab Immune Disord Drug Targets. 2016. PMID: 27784231
INTRODUCTION: Methadone is the most common opioid in use for opioid substitution therapy. ...CONCLUSION: Electrocardiographic changes are an important complication of methadone that seems to be related to low testosterone level in men....
INTRODUCTION: Methadone is the most common opioid in use for opioid substitution therapy. ...CONCLUSION: Electrocardiographic changes …
Fetal assessment before and after dosing with buprenorphine or methadone.
Salisbury AL, Coyle MG, O'Grady KE, Heil SH, Martin PR, Stine SM, Kaltenbach K, Weninger M, Jones HE. Salisbury AL, et al. Addiction. 2012 Nov;107 Suppl 1(0 1):36-44. doi: 10.1111/j.1360-0443.2012.04037.x. Addiction. 2012. PMID: 23106925 Free PMC article. Clinical Trial.
The decrease in accelerations and reactive NST were significant only for fetuses in the methadone group, and this resulted in a significantly lower likelihood of a reactive NST compared to fetuses in the buprenorphine group. CONCLUSION: Buprenorphine compared with metha
The decrease in accelerations and reactive NST were significant only for fetuses in the methadone group, and this resulted in a signi …
Risk Factors and Prevalence of QTc Prolongation in Adult Burn Patients Receiving Methadone.
Walroth TA, Boyd AN, Hester AM, Schoenle MK, Hartman BC, Sood R. Walroth TA, et al. J Burn Care Res. 2020 Feb 19;41(2):416-420. doi: 10.1093/jbcr/irz200. J Burn Care Res. 2020. PMID: 31808804
One adverse effect of methadone is QTc interval prolongation, which may be associated with adverse cardiac outcomes. ...QTc prolongation in burn patients was associated with increased methadone dose and resulted in a higher rate of cardiac events. This …
One adverse effect of methadone is QTc interval prolongation, which may be associated with adverse cardiac outcomes. ...QTc pr …
Methadone and Corrected QT Prolongation in Pain and Palliative Care Patients: A Case-Control Study.
Juba KM, Khadem TM, Hutchinson DJ, Brown JE. Juba KM, et al. J Palliat Med. 2017 Jul;20(7):722-728. doi: 10.1089/jpm.2016.0411. Epub 2017 Feb 10. J Palliat Med. 2017. PMID: 28186837
BACKGROUND: Methadone (ME) is commonly used in pain and palliative care (PPC) patients with refractory pain or intolerable opioid adverse effects (AEs). A unique ME AE is its corrected QT (QTc) interval prolongation risk, but most evidence exists in methadone mainte …
BACKGROUND: Methadone (ME) is commonly used in pain and palliative care (PPC) patients with refractory pain or intolerable opioid adv …
151 results