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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 2
1971 6
1972 11
1973 5
1974 12
1975 5
1976 10
1977 11
1978 10
1979 10
1980 6
1981 9
1982 4
1983 6
1984 6
1985 9
1986 7
1987 7
1988 5
1989 10
1990 10
1991 10
1992 3
1993 4
1994 7
1996 8
1997 9
1998 2
1999 5
2000 5
2001 2
2002 5
2003 2
2004 3
2005 4
2006 7
2007 4
2008 4
2009 5
2010 2
2011 2
2012 4
2013 9
2014 12
2015 7
2016 7
2017 9
2018 5
2019 6
2020 8
2021 10
2022 9
2023 0
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323 results
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Metolazone.
[No authors listed] [No authors listed] 2021 Jan 18. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2021 Jan 18. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000088 Free Books & Documents. Review.
No information is available on the amount of metolazone in breastmilk. Intense diuresis with large doses may decrease breastmilk production. Other diuretics in low doses are preferred over metolazone....
No information is available on the amount of metolazone in breastmilk. Intense diuresis with large doses may decrease breastmilk prod …
Metolazone.
Bond G, Adnan G, Dua A, Singh K, Crew CM. Bond G, et al. 2022 Nov 9. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. 2022 Nov 9. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 30480942 Free Books & Documents.
Metolazone is a cardiovascular agent, specifically a quinazoline diuretic related to the thiazide class. ...The FDA has approved metolazone to treat salt and water retention, causing edema accompanying congestive heart failure or kidney disease. ...
Metolazone is a cardiovascular agent, specifically a quinazoline diuretic related to the thiazide class. ...The FDA has approved m
Metolazone Versus Intravenous Chlorothiazide for Decompensated Heart Failure Sequential Nephron Blockade: A Retrospective Cohort Study.
Cisowska T, Pan IZ, Biskupiak J, Shah KS, Fang JC, Jacobs JA. Cisowska T, et al. J Card Fail. 2022 Aug;28(8):1367-1371. doi: 10.1016/j.cardfail.2022.05.011. Epub 2022 Jun 7. J Card Fail. 2022. PMID: 35688407
Previous studies suggest metolazone may be comparable with chlorothiazide in terms of efficacy and safety. ...Preferential metolazone use in SNB is a potential cost-saving measure....
Previous studies suggest metolazone may be comparable with chlorothiazide in terms of efficacy and safety. ...Preferential metolaz
Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans.
Ito A, Zhao Q, Tanaka Y, Yasui M, Katayama R, Sun S, Tanimoto Y, Nishikawa Y, Kage-Nakadai E. Ito A, et al. Biogerontology. 2021 Feb;22(1):119-131. doi: 10.1007/s10522-020-09907-6. Epub 2020 Nov 20. Biogerontology. 2021. PMID: 33216250
Metolazone also extended the lifespan of worms in a atfs-1 and ubl-5-dependent manner. Notably, metolazone failed to increase lifespan in worms with knocked-down nkcc-1. ...
Metolazone also extended the lifespan of worms in a atfs-1 and ubl-5-dependent manner. Notably, metolazone failed to increase
Diuretics.
[No authors listed] [No authors listed] 2021 Oct 13. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2021 Oct 13. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31644115 Free Books & Documents. Review.
Diuretics are typically classified as thiazide diuretics (bendroflumethiazide, chlorothiazide, chlorthalidone, hydrochlorothiazide, indapamide, metolazone and polythiazide), loop diuretics (bumetanide, ethacrynic acid, furosemide, and torsemide), and potassium-sparing agen …
Diuretics are typically classified as thiazide diuretics (bendroflumethiazide, chlorothiazide, chlorthalidone, hydrochlorothiazide, indapami …
Metolazone and its role in edema management.
Sica DA. Sica DA. Congest Heart Fail. 2003 Mar-Apr;9(2):100-5. doi: 10.1111/j.1527-5299.2003.01907.x. Congest Heart Fail. 2003. PMID: 12671341 Free article. Review.
Metolazone is commonly administered in conjunction with a loop diuretic to manage volume overload in patients otherwise resistant to loop diuretic therapy alone. Metolazone is a thiazide-type diuretic that is characterized by slow and sometimes erratic absorption wh
Metolazone is commonly administered in conjunction with a loop diuretic to manage volume overload in patients otherwise resistant to
Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure: The 3T Trial.
Cox ZL, Hung R, Lenihan DJ, Testani JM. Cox ZL, et al. JACC Heart Fail. 2020 Mar;8(3):157-168. doi: 10.1016/j.jchf.2019.09.012. Epub 2019 Dec 11. JACC Heart Fail. 2020. PMID: 31838029 Free PMC article. Clinical Trial.

Serum sodium decreased less with tolvaptan than with metolazone (+4 5 vs. -1 3 mEq/l; p = 0.001), but 48-h spot urine sodium was lower with tolvaptan (58 25 mmol/l) than with metolazone (104 16 mmol/l; p = 0.002) and with chlorothiazide (117 14 mmol/l; p < 0.001)

Serum sodium decreased less with tolvaptan than with metolazone (+4 5 vs. -1 3 mEq/l; p = 0.001), but 48-h spot urine sodium was lowe …
Drugs for hypertension.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2020 May 18;62(1598):73-80. Med Lett Drugs Ther. 2020. PMID: 32555118 No abstract available.
Thiazide Diuretics in Chronic Kidney Disease.
Sinha AD, Agarwal R. Sinha AD, et al. Curr Hypertens Rep. 2015 Mar;17(3):13. doi: 10.1007/s11906-014-0525-x. Curr Hypertens Rep. 2015. PMID: 25749608 Review.
We review the updated guidelines on thiazide use in advanced CKD, the antihypertensive mechanism of thiazides, and the clinical studies of thiazides in CKD. Older uncontrolled studies have shown that metolazone reduces blood pressure in CKD, but more recently small randomi …
We review the updated guidelines on thiazide use in advanced CKD, the antihypertensive mechanism of thiazides, and the clinical studies of t …
Formulation, Characterization, and the Diuretic Effects of a New Intravenous Metolazone Emulsion.
Ahlschwede KM, Ofori E, Andey T, Osei A, Somberg JS. Ahlschwede KM, et al. Drug Res (Stuttg). 2022 Jul;72(6):299-305. doi: 10.1055/a-1813-9489. Epub 2022 May 10. Drug Res (Stuttg). 2022. PMID: 35537450
In addition, metolazone is poorly water-soluble, thereby rendering intravenous formulation more challenging. ...The emulsion was characterized on the basis of particle size, zeta potential, morphology and metolazone release kinetics. The diuretic effect of the me
In addition, metolazone is poorly water-soluble, thereby rendering intravenous formulation more challenging. ...The emulsion was char …
323 results