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Year Number of Results
1991 1
1998 1
1999 1
2001 1
2002 1
2007 1
2013 1
2015 1
2016 1
2017 2
2018 2
2023 0
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Page 1
Oral mucosal drug delivery: clinical pharmacokinetics and therapeutic applications.
Zhang H, Zhang J, Streisand JB. Zhang H, et al. Clin Pharmacokinet. 2002;41(9):661-80. doi: 10.2165/00003088-200241090-00003. Clin Pharmacokinet. 2002. PMID: 12126458 Review.
Oral mucosal drug delivery is an alternative method of systemic drug delivery that offers several advantages over both injectable and enteral methods. ...Oral transmucosal formulations of testosterone and estrogen have been developed. ...
Oral mucosal drug delivery is an alternative method of systemic drug delivery that offers several advantages over both …
Intravenous and Intramuscular Formulations of Antiseizure Drugs in the Treatment of Epilepsy.
Patel SI, Birnbaum AK, Cloyd JC, Leppik IE. Patel SI, et al. CNS Drugs. 2015 Dec;29(12):1009-22. doi: 10.1007/s40263-015-0289-0. CNS Drugs. 2015. PMID: 26603741 Review.
Intravenous and intramuscular antiseizure drugs (ASDs) are essential in the treatment of clinical seizure emergencies as well as in replacement therapy when oral administration is not possible. The parenteral formulations provide rapid delivery and complete (intrave …
Intravenous and intramuscular antiseizure drugs (ASDs) are essential in the treatment of clinical seizure emergencies as well as in replacem …
Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance.
Vanhove T, de Jonge H, de Loor H, Annaert P, Diczfalusy U, Kuypers DR. Vanhove T, et al. Br J Clin Pharmacol. 2016 Dec;82(6):1539-1549. doi: 10.1111/bcp.13083. Epub 2016 Sep 20. Br J Clin Pharmacol. 2016. PMID: 27501475 Free PMC article.
AIMS: We compared the CYP3A4 metrics weight-corrected midazolam apparent oral clearance (MDZ Cl/F/W) and plasma 4beta-hydroxycholesterol/cholesterol (4beta-OHC/C) as they relate to tacrolimus (TAC) Cl/F/W in renal transplant recipients. ...For CYP3A5 non-expressors …
AIMS: We compared the CYP3A4 metrics weight-corrected midazolam apparent oral clearance (MDZ Cl/F/W) and plasma 4beta-hydroxyc …
Effect of saquinavir on the pharmacokinetics and pharmacodynamics of oral and intravenous midazolam.
Palkama VJ, Ahonen J, Neuvonen PJ, Olkkola KT. Palkama VJ, et al. Clin Pharmacol Ther. 1999 Jul;66(1):33-9. doi: 10.1016/S0009-9236(99)70051-2. Clin Pharmacol Ther. 1999. PMID: 10430107 Clinical Trial.
On day 3, six subjects were given 7.5 mg oral midazolam and the other six subjects received 0.05 mg/kg intravenous midazolam. On day 5, the subjects who had received oral midazolam on day 3 received intravenously midazolam and vice versa. …
On day 3, six subjects were given 7.5 mg oral midazolam and the other six subjects received 0.05 mg/kg intravenous midazola …
Preparation and Evaluation of Midazolam Rectal Gel in vitro and in vivo.
Chen X, Li W, Li Y, Guo F, Zhang H, Gao J, Sun J, Zheng A. Chen X, et al. Drug Res (Stuttg). 2018 Oct;68(10):560-566. doi: 10.1055/a-0589-9886. Epub 2018 Apr 9. Drug Res (Stuttg). 2018. PMID: 29631297
Midazolam has been successfully used for sedation, which the tablets, injections and oral solutions were available in market. However, the oral bioavailability of midazolam is less due to the first effect, while injection formulation …
Midazolam has been successfully used for sedation, which the tablets, injections and oral solutions were available in m …
The effect of multiple-dose, oral rifaximin on the pharmacokinetics of intravenous and oral midazolam in healthy volunteers.
Pentikis HS, Connolly M, Trapnell CB, Forbes WP, Bettenhausen DK. Pentikis HS, et al. Pharmacotherapy. 2007 Oct;27(10):1361-9. doi: 10.1592/phco.27.10.1361. Pharmacotherapy. 2007. PMID: 17896891 Clinical Trial.
On days 6 (after the 9th dose of rifaximin) and 10 (after the 21st dose of rifaximin), subjects received a concomitant single dose of intravenous or oral midazolam. After a 15-day washout period, subjects were crossed over to the other formulation of midaz …
On days 6 (after the 9th dose of rifaximin) and 10 (after the 21st dose of rifaximin), subjects received a concomitant single dose of intrav …
A Two-way Randomized Cross-over Pharmacokinetic and Pharmacodynamic Study of an Innovative Oral Solution of Midazolam (ADV6209).
Guittet C, Manso M, Burton I, Granier LA, Marçon F. Guittet C, et al. Pharm Res. 2017 Sep;34(9):1840-1848. doi: 10.1007/s11095-017-2193-4. Epub 2017 Jun 2. Pharm Res. 2017. PMID: 28577272 Clinical Trial.
METHODS: A bioavailability study with a standard two-sequences, two-periods, and crossover design was conducted. Subjects randomly received 15 mg of ADV6209 by oral route followed by 5 mg of the reference drug (midazolam hydrochloride intravenous solution (Hy …
METHODS: A bioavailability study with a standard two-sequences, two-periods, and crossover design was conducted. Subjects randomly received …
The single-dose pharmacokinetics of midazolam and its primary metabolite in pediatric patients after oral and intravenous administration.
Reed MD, Rodarte A, Blumer JL, Khoo KC, Akbari B, Pou S, Pharmd, Kearns GL; Pediatric Pharmacology Research Unit Network. Reed MD, et al. J Clin Pharmacol. 2001 Dec;41(12):1359-69. doi: 10.1177/00912700122012832. J Clin Pharmacol. 2001. PMID: 11762564 Clinical Trial.
Eligible study patients were enrolled into one of three study arms: Arm I (midazolam/metabolite pharmacokinetic evaluation after oral administration of a syrup formulation), Arm II (the absolute bioavailability of midazolam syrup), and Arm III (mida …
Eligible study patients were enrolled into one of three study arms: Arm I (midazolam/metabolite pharmacokinetic evaluation after o …
Pharmacokinetics of rectal drug administration, Part I. General considerations and clinical applications of centrally acting drugs.
van Hoogdalem E, de Boer AG, Breimer DD. van Hoogdalem E, et al. Clin Pharmacokinet. 1991 Jul;21(1):11-26. doi: 10.2165/00003088-199121010-00002. Clin Pharmacokinet. 1991. PMID: 1717195 Review.
It may also represent an interesting alternative to intravenous or other injection routes of drug administration. The rate and extent of rectal drug absorption are often lower than with oral absorption, possibly an inherent factor owing to the relative …
It may also represent an interesting alternative to intravenous or other injection routes of drug administration. The rate and …
Stability of midazolam in syrspend SF and syrspend SF cherry.
Geiger CM, Sorenson B, Whaley PA. Geiger CM, et al. Int J Pharm Compd. 2013 Jul-Aug;17(4):344-6. Int J Pharm Compd. 2013. PMID: 24261150
Midazolam is a short-acting benzodiazepine central nervous system depressant available as an injection, tablet, or oral syrup. The need for alternative dosage form options for patients unable to take tablets and shortages of other forms of the drug hav …
Midazolam is a short-acting benzodiazepine central nervous system depressant available as an injection, tablet, or oral …
12 results