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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
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1990 5
1991 9
1992 7
1993 4
1994 4
1995 4
1996 3
1999 1
2000 1
2023 0
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42 results
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Page 1
Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial.
Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, Arensberg D, Baker A, Friedman L, Greene HL, et al. Echt DS, et al. N Engl J Med. 1991 Mar 21;324(12):781-8. doi: 10.1056/NEJM199103213241201. N Engl J Med. 1991. PMID: 1900101 Free article. Clinical Trial.
The use of encainide and flecainide was discontinued because of excess mortality. We examined the mortality and morbidity after randomization to encainide or flecainide or their respective placebo. ...Nonlethal events, however, were equally distributed between the a …
The use of encainide and flecainide was discontinued because of excess mortality. We examined the mortality and morbidity afte …
Moricizine. A review of its pharmacological properties, and therapeutic efficacy in cardiac arrhythmias.
Fitton A, Buckley MT. Fitton A, et al. Drugs. 1990 Jul;40(1):138-67. doi: 10.2165/00003495-199040010-00007. Drugs. 1990. PMID: 2202581 Review.
Moricizine (moracizine, ethmozine) is an orally active phenothiazine derivative with direct myocardial Class I antiarrhythmic activity and minimal CNS effects. ...Further studies are required to confirm its long term efficacy and effects on mortality when used proph …
Moricizine (moracizine, ethmozine) is an orally active phenothiazine derivative with direct myocardial Class I antiarrhythmic activit …
Interaction of baseline characteristics with the hazard of encainide, flecainide, and moricizine therapy in patients with myocardial infarction. A possible explanation for increased mortality in the Cardiac Arrhythmia Suppression Trial (CAST).
Anderson JL, Platia EV, Hallstrom A, Henthorn RW, Buckingham TA, Carlson MD, Carson PE. Anderson JL, et al. Circulation. 1994 Dec;90(6):2843-52. doi: 10.1161/01.cir.90.6.2843. Circulation. 1994. PMID: 7994829 Clinical Trial.
The encainide and flecainide arms of the study were discontinued in 1989 (CAST-I) and the moricizine arm in 1991 (CAST-II) because of excess mortality. To explore the mechanisms of these adverse outcomes, we examined the interaction of baseline characteristics with …
The encainide and flecainide arms of the study were discontinued in 1989 (CAST-I) and the moricizine arm in 1991 (CAST-II) because of …
Comparisons of efficacy and tolerance of moricizine with other antiarrhythmic agents in the treatment of chronic ventricular arrhythmias.
Anderson JL. Anderson JL. Am J Cardiol. 1990 Feb 20;65(8):32D-40D. doi: 10.1016/0002-9149(90)91415-3. Am J Cardiol. 1990. PMID: 2106254 Review.
Furthermore, the Cardiac Arrhythmia Pilot Study compared moricizine in postinfarction patients with encainide and flecainide. ...Although the class IC drugs (encainide and flecainide) showed somewhat greater efficacy in the Cardiac Arrhythmic Pilot Study, they are now know …
Furthermore, the Cardiac Arrhythmia Pilot Study compared moricizine in postinfarction patients with encainide and flecainide. ...Alth …
Mortality following ventricular arrhythmia suppression by encainide, flecainide, and moricizine after myocardial infarction. The original design concept of the Cardiac Arrhythmia Suppression Trial (CAST).
Epstein AE, Hallstrom AP, Rogers WJ, Liebson PR, Seals AA, Anderson JL, Cohen JD, Capone RJ, Wyse DG. Epstein AE, et al. JAMA. 1993 Nov 24;270(20):2451-5. JAMA. 1993. PMID: 8230622 Clinical Trial.
PATIENTS: A total of 3549 patients with myocardial infarction and left ventricular dysfunction. INTERVENTION: Administration of encainide, flecainide, moricizine, or placebo to suppress ventricular premature depolarizations. ...CONCLUSIONS: The suppression of asymptomatic …
PATIENTS: A total of 3549 patients with myocardial infarction and left ventricular dysfunction. INTERVENTION: Administration of encainide, f …
Effect of moricizine on heart rate variability in normal subjects.
Stein PK, Rottman JN, Kuru T, Kleiger RE. Stein PK, et al. Int J Cardiol. 1995 Jan 27;48(1):59-65. doi: 10.1016/0167-5273(94)02220-d. Int J Cardiol. 1995. PMID: 7744539 Clinical Trial.
We investigated the effects of moricizine HCl, a type Ic anti-arrhythmic agent, on heart rate variability. ...Moricizine decreased both time and frequency domain measures of heart rate variability. ...
We investigated the effects of moricizine HCl, a type Ic anti-arrhythmic agent, on heart rate variability. ...Moricizine decre …
Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction.
Cardiac Arrhythmia Suppression Trial II Investigators. Cardiac Arrhythmia Suppression Trial II Investigators. N Engl J Med. 1992 Jul 23;327(4):227-33. doi: 10.1056/NEJM199207233270403. N Engl J Med. 1992. PMID: 1377359 Free article. Clinical Trial.
RESULTS: CAST-II was stopped early because the first 14-day period of treatment with moricizine after a myocardial infarction was associated with excess mortality (17 of 665 patients died or had cardiac arrests), as compared with no treatment or placebo (3 of 660 pa …
RESULTS: CAST-II was stopped early because the first 14-day period of treatment with moricizine after a myocardial infarction was ass …
Relations between heart failure, ejection fraction, arrhythmia suppression and mortality: analysis of the Cardiac Arrhythmia Suppression Trial.
Hallstrom A, Pratt CM, Greene HL, Huther M, Gottlieb S, DeMaria A, Young JB. Hallstrom A, et al. J Am Coll Cardiol. 1995 May;25(6):1250-7. doi: 10.1016/0735-1097(94)00553-3. J Am Coll Cardiol. 1995. PMID: 7722117 Free article. Clinical Trial.
OBJECTIVES: We studied the relations between heart failure, ejection fraction, arrhythmia suppression and mortality. BACKGROUND: Both left ventricular ejection fraction and functional class of heart failure are strongly associated with mortality after acute myocardi …
OBJECTIVES: We studied the relations between heart failure, ejection fraction, arrhythmia suppression and mortality. BACKGROUND: Both …
Treatment of ventricular arrhythmias after CAST.
Tonkin AM. Tonkin AM. Med J Aust. 1992 Apr 6;156(7):488-92. doi: 10.5694/j.1326-5377.1992.tb126477.x. Med J Aust. 1992. PMID: 1372950 Review.
On the recommendation of the Data and Safety Monitoring Board the trial in these groups was terminated. More recently CAST II in which moricizine was compared to placebo was also terminated, again because of a higher mortality in the patients receiving active treatm …
On the recommendation of the Data and Safety Monitoring Board the trial in these groups was terminated. More recently CAST II in which mo …
Predicting mortality after myocardial infarction from the response of RR variability to antiarrhythmic drug therapy.
Bigger JT Jr, Rolnitzky LM, Steinman RC, Fleiss JL. Bigger JT Jr, et al. J Am Coll Cardiol. 1994 Mar 1;23(3):733-40. doi: 10.1016/0735-1097(94)90761-7. J Am Coll Cardiol. 1994. PMID: 7509355 Free article. Clinical Trial.
The investigators of that study speculated that changes in RR variability during antiarrhythmic drug therapy predict an increased mortality rate during long-term drug treatment. To explore this hypothesis further, we compared the effects of encainide and flecainide, which …
The investigators of that study speculated that changes in RR variability during antiarrhythmic drug therapy predict an increased mortali …
42 results