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Gabapentin increases the abuse liability of alcohol alone and in combination with oxycodone in participants with co-occurring opioid and alcohol use disorder.
Castillo F, Jones JD, Luba RR, Mogali S, Foltin RW, Evans SM, Comer SD. Castillo F, et al. Pharmacol Biochem Behav. 2022 Nov;221:173482. doi: 10.1016/j.pbb.2022.173482. Epub 2022 Oct 13. Pharmacol Biochem Behav. 2022. PMID: 36244527 Clinical Trial.
METHODS: During an 8-week, inpatient, within-subject, randomized, double-blind, placebo-controlled crossover study, non-treatment seeking participants (N = 13; 12 M/1F; 44.1 3 years of age) with OUD and AUD were maintained on oral morphine (120 mg daily). ...Gabapen …
METHODS: During an 8-week, inpatient, within-subject, randomized, double-blind, placebo-controlled crossover study, non-treatment see …
Abuse liability and pharmacodynamic characteristics of intravenous and inhaled nicotine.
Henningfield JE, Miyasato K, Jasinski DR. Henningfield JE, et al. J Pharmacol Exp Ther. 1985 Jul;234(1):1-12. J Pharmacol Exp Ther. 1985. PMID: 4009494 Clinical Trial.
The potential role of nicotine in tobacco dependence was investigated using the strategies of abuse liability assessment. Eight male volunteer cigarette smokers with histories of drug abuse resided on a research ward for the duration of the study. ...Nicotine …
The potential role of nicotine in tobacco dependence was investigated using the strategies of abuse liability assessment. Eigh …
Evaluation of morphine-like effects of the mixed mu/delta agonist morphine-6-O-sulfate in rats: Drug discrimination and physical dependence.
Yadlapalli JSK, Bommagani SB, Mahelona RD, Wan A, Gannon BM, Penthala NR, Dobretsov M, Crooks PA, Fantegrossi WE. Yadlapalli JSK, et al. Pharmacol Res Perspect. 2018 Jun 19;6(4):e00403. doi: 10.1002/prp2.403. eCollection 2018 Jul. Pharmacol Res Perspect. 2018. PMID: 29930811 Free PMC article.
Morphine-6-O-sulfate (M6S) is as a mixed-action mu/delta (mu/delta) opioid receptor agonist with high potency and analgesic efficacy. These studies used assays of drug discrimination and schedule-controlled responding to assess abuse-liability,
Morphine-6-O-sulfate (M6S) is as a mixed-action mu/delta (mu/delta) opioid receptor agonist with high potency and analgesic ef
Abuse liability of prescription opioids compared to heroin in morphine-maintained heroin abusers.
Comer SD, Sullivan MA, Whittington RA, Vosburg SK, Kowalczyk WJ. Comer SD, et al. Neuropsychopharmacology. 2008 Apr;33(5):1179-91. doi: 10.1038/sj.npp.1301479. Epub 2007 Jun 20. Neuropsychopharmacology. 2008. PMID: 17581533 Free PMC article. Clinical Trial.
However, few studies have systematically examined the relative reinforcing effects of commonly abused opioid medications. The current double-blind, placebo-controlled in-patient study was designed to compare the effects of intravenously delivered fentanyl (0, 0.0625 …
However, few studies have systematically examined the relative reinforcing effects of commonly abused opioid medications. The current …
Butorphanol tartrate (stadol): a review.
Vogelsang J, Hayes SR. Vogelsang J, et al. J Post Anesth Nurs. 1991 Apr;6(2):129-35. J Post Anesth Nurs. 1991. PMID: 1848891 Review.
Theoretically it offers an advantage over traditional opiates such as morphine and meperidine in the treatment of moderate pain. Butorphanol has been used as a preoperative sedative and analgesic, as a supplement to balanced anesthesia, and for suppression of postanesthesi …
Theoretically it offers an advantage over traditional opiates such as morphine and meperidine in the treatment of moderate pain. Buto …
Assessment of abuse liability of Tramadol among experienced drug users: Double-blind crossover randomized controlled trial.
Das M, Jain R, Dhawan A, Kaur A. Das M, et al. J Opioid Manag. 2016 Nov/Dec;12(6):421-430. doi: 10.5055/jom.2016.0361. J Opioid Manag. 2016. PMID: 28059434 Clinical Trial.
Total subjects were 10, comprising total 120 observations (each subject assessed at baseline, 5, 45, and 240 minutes). Subjects with history of substance abuse were included after detoxification and informed consent. ...All the subjects liked Buprenorphine most and …
Total subjects were 10, comprising total 120 observations (each subject assessed at baseline, 5, 45, and 240 minutes). Subjects with history …
Abuse liability assessment of hydrocodone under current draft regulatory guidelines.
Gauvin DV, McComb M, Code R, Dalton JA, Baird TJ. Gauvin DV, et al. J Pharmacol Toxicol Methods. 2015 Sep-Oct;75:118-29. doi: 10.1016/j.vascn.2015.05.003. Epub 2015 May 9. J Pharmacol Toxicol Methods. 2015. PMID: 25969422
INTRODUCTION: The abuse liability of hydrocodone was assessed in male Sprague-Dawley rats under the European Medicines Agency, the International Commission on Harmonisation, and the U.S. ...Controlled Substance Act....
INTRODUCTION: The abuse liability of hydrocodone was assessed in male Sprague-Dawley rats under the European Medicines Agency, …
Evaluation of mixtures of morphine and d-amphetamine for subjective and physiological effects.
Jasinski DR, Preston KL. Jasinski DR, et al. Drug Alcohol Depend. 1986 May;17(1):1-13. doi: 10.1016/0376-8716(86)90031-1. Drug Alcohol Depend. 1986. PMID: 3720527 Clinical Trial.
Subjective, physiological and behavioral effects of the combination were assessed in the present study to determine whether the abuse liability of the combination might also be enhanced. Single intramuscular doses of morphine and d-amphetamine alone and in co …
Subjective, physiological and behavioral effects of the combination were assessed in the present study to determine whether the abuse
Positive subjective measures in abuse liability studies and real-world nonmedical use: Potential impact of abuse-deterrent opioids on rates of nonmedical use and associated healthcare costs.
White AG, LeCates J, Birnbaum HG, Cheng W, Roland CL, Mardekian J. White AG, et al. J Opioid Manag. 2015 May-Jun;11(3):199-210. doi: 10.5055/jom.2015.0269. J Opioid Manag. 2015. PMID: 25985805
OBJECTIVE: To quantify the potential impact of reductions in positive subjective measures from human abuse liability studies on real-world rates of nonmedical use of prescription drugs and associated healthcare resource utilization and costs. ...Nonmedical use data …
OBJECTIVE: To quantify the potential impact of reductions in positive subjective measures from human abuse liability studies o …
Intravenous Tramadol is Effective in the Management of Postoperative Pain Following Abdominoplasty: A Three-Arm Randomized Placebo- and Active-Controlled Trial.
Minkowitz H, Salazar H, Leiman D, Solanki D, Lu L, Reines S, Ryan M, Harnett M, Singla N. Minkowitz H, et al. Drugs R D. 2020 Sep;20(3):225-236. doi: 10.1007/s40268-020-00309-0. Drugs R D. 2020. PMID: 32409981 Free PMC article. Clinical Trial.
BACKGROUND AND OBJECTIVE: Oral tramadol, an atypical opioid approved in the United States (US) since 1995 and a Schedule IV controlled substance, has less abuse liability compared to Schedule II conventional opioids. ...METHODS: A phase 3, multicenter, …
BACKGROUND AND OBJECTIVE: Oral tramadol, an atypical opioid approved in the United States (US) since 1995 and a Schedule IV controlled
13 results