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Page 1
Nucleoside Analogues.
[No authors listed] [No authors listed] 2020 May 1. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2020 May 1. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31644243 Free Books & Documents. Review.
Mitochondrial injury can affect multiple tissues thereby causing myopathy, neuropathy, pancreatitis, bone marrow suppression and/or hepatic injury. The hepatic injury is characterized by accumulation of lactic acidosis, microvesicular steatosis and hepatic synthetic …
Mitochondrial injury can affect multiple tissues thereby causing myopathy, neuropathy, pancreatitis, bone marrow suppression and/or hepatic …
Successful Treatment of Tenofovir Alafenamide-Induced Lactic Acidosis: A Case Report.
Arnouk S, Whitsett M, Papadopoulos J, Stewart Lewis Z, Dagher NN, Feldman DM, Park JS. Arnouk S, et al. J Pharm Pract. 2022 May 28:8971900221105042. doi: 10.1177/08971900221105042. Online ahead of print. J Pharm Pract. 2022. PMID: 35635046
Nucleoside or nucleotide analogues (NAs) have the potential to cause lactic acidosis by inhibiting DNA polymerase-gamma of human mitochondria and impairing aerobic metabolism. ...There is a paucity of data to guide management of life-threatening lactic aci
Nucleoside or nucleotide analogues (NAs) have the potential to cause lactic acidosis by inhibiting DNA polymerase-gamma of hum …
A review of the toxicity of HIV medications.
Margolis AM, Heverling H, Pham PA, Stolbach A. Margolis AM, et al. J Med Toxicol. 2014 Mar;10(1):26-39. doi: 10.1007/s13181-013-0325-8. J Med Toxicol. 2014. PMID: 23963694 Free PMC article. Review.
Older NRTIs were associated with mitochondrial toxicity, but this is less common in the newer drugs, emtricitabine, lamivudine, and tenofovir. Mitochondrial toxicity results from NRTI inhibition of a mitochondrial DNA polymerase. Mitochondrial toxicity manifests as myopath …
Older NRTIs were associated with mitochondrial toxicity, but this is less common in the newer drugs, emtricitabine, lamivudine, and tenof
Case report: lactic acidosis and rhabdomyolysis during telbivudine and tenofovir treatment for chronic hepatitis B.
Ying Y, Hu YK, Jin JL, Zhang JM, Zhang WH, Huang YX. Ying Y, et al. BMC Gastroenterol. 2018 Apr 6;18(1):45. doi: 10.1186/s12876-018-0773-3. BMC Gastroenterol. 2018. PMID: 29625557 Free PMC article.
Previously 12.9% of patients on telbivudine treatment were reported to develop severe elevation of serum creatine phosphokinase (CPK) levels, but related clinical disease, like lactic acidosis (LA) and rhabdomyolysis (RM) were rare. The pathophysiology may be mitoch …
Previously 12.9% of patients on telbivudine treatment were reported to develop severe elevation of serum creatine phosphokinase (CPK) levels …
Severe Lactic Acidosis Due to Acute Intoxication by Emtricitabine/Tenofovir Alafenamide.
Chaparala S, Da Silva RC, Papadopoulos JP. Chaparala S, et al. Cureus. 2021 Oct 24;13(10):e19008. doi: 10.7759/cureus.19008. eCollection 2021 Oct. Cureus. 2021. PMID: 34824925 Free PMC article.
Patient developed severe lactic acidosis early in the admission, secondary as to a possible mitochondrial toxicity. ...Her metabolic profile also showed remarkable improvement and the metabolic lactic acidosis resolved. The previous formulation of t
Patient developed severe lactic acidosis early in the admission, secondary as to a possible mitochondrial toxicity. ...Her met …
Lactic acidosis after concomitant treatment with metformin and tenofovir in a patient with HIV infection.
Aperis G, Paliouras C, Zervos A, Arvanitis A, Alivanis P. Aperis G, et al. J Ren Care. 2011 Mar;37(1):25-9. doi: 10.1111/j.1755-6686.2011.00209.x. J Ren Care. 2011. PMID: 21288314
We present an uncommon case of lactic acidosis after concomitant administration of Metformin and Tenofovir. ...Health professionals must be aware of this uncommon effect in patients on antiretroviral treatment. Prompt initiation of CVVHF resulted in resolutio …
We present an uncommon case of lactic acidosis after concomitant administration of Metformin and Tenofovir. ...Health p …
Fatal Tenofovir-Associateacd Lactic Acidosis: A Case Report.
Hashim H, Sahari NS, Sazlly Lim SM, Hoo FK. Hashim H, et al. Iran Red Crescent Med J. 2015 Oct 24;17(10):e19546. doi: 10.5812/ircmj.19546. eCollection 2015 Oct. Iran Red Crescent Med J. 2015. PMID: 26568856 Free PMC article.
The purpose of this paper is to report a case of tenofovir induced lactic acidosis and review the literature. CASE PRESENTATION: A 52-year-old Malay gentleman, with hepatitis C virus and HIV infection was admitted to the intensive care unit for severe lact
The purpose of this paper is to report a case of tenofovir induced lactic acidosis and review the literature. CASE PRES …
Fatal lactic acidosis associated with coadministration of didanosine and tenofovir disoproxil fumarate.
Guo Y, Fung HB. Guo Y, et al. Pharmacotherapy. 2004 Aug;24(8):1089-94. doi: 10.1592/phco.24.11.1089.36138. Pharmacotherapy. 2004. PMID: 15338857
Lactic acidosis is an uncommon but potentially life-threatening adverse effect of didanosine. ...Health care providers should maintain a high index of suspicion for lactic acidosis in patients with HIV infection who receive didanosine and tenofovir
Lactic acidosis is an uncommon but potentially life-threatening adverse effect of didanosine. ...Health care providers should
Tenofovir alafenamide associated fatal lactic acidosis in an autologous hematopoietic stem cell transplant recipient.
Alsunaid SR, Ashraf H, Soubani AO. Alsunaid SR, et al. Transpl Infect Dis. 2018 Oct;20(5):e12960. doi: 10.1111/tid.12960. Epub 2018 Jul 18. Transpl Infect Dis. 2018. PMID: 29975806
Fatal lactic acidosis has been reported while on the treatment with Nucleoside/nucleotide analogues (NA) for the treatment of hepatitis B, C and HIV. ...He presented few weeks later with severe lactic acidosis. Other causes of lactic acidosis
Fatal lactic acidosis has been reported while on the treatment with Nucleoside/nucleotide analogues (NA) for the treatment of …
48 results