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1993 1
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15 results
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Page 1
Effect of prechemotherapy filgrastim on the bone marrow toxicity of topotecan.
Ozan H, Ozkalemkas F, Ozan U, Ozerkan K, Bilgin T, Küçükyildiz F. Ozan H, et al. Eur J Gynaecol Oncol. 2001;22(6):463-5. Eur J Gynaecol Oncol. 2001. PMID: 11874084
PURPOSE: To investigate the efficacy and safety of single-dose filgrastim administered 24 hours prior to chemotherapy in the prevention of topotecan-related myeloid suppression. METHODS: No medication was given to 21 rats in group 1; 1.5 mg/m2/day topotecan w …
PURPOSE: To investigate the efficacy and safety of single-dose filgrastim administered 24 hours prior to chemotherapy in the prevention of …
Topotecan treatment and its toxic effects on hematologic parameters and trace elements.
Bülbül Hizel S, Sanli C, Bayar Muluk N, Albayrak M, Ozyazici A, Apan A. Bülbül Hizel S, et al. Biol Trace Elem Res. 2008 Aug;124(2):129-34. doi: 10.1007/s12011-008-8140-9. Epub 2008 May 23. Biol Trace Elem Res. 2008. PMID: 18498005
The study was conducted on three groups consisting of 16 and 18 rabbits in the study groups and 15 rabbits in the control group. Rabbits in group I (n = 16) received high-dose topotecan intravenously (i.v.; 0.5 mg/kg once daily), while rabbits in group II (n = 18) received …
The study was conducted on three groups consisting of 16 and 18 rabbits in the study groups and 15 rabbits in the control group. Rabbits in …
Response to paclitaxel, topotecan, and topotecan-cyclophosphamide in children with untreated disseminated neuroblastoma treated in an upfront phase II investigational window: a pediatric oncology group study.
Kretschmar CS, Kletzel M, Murray K, Thorner P, Joshi V, Marcus R, Smith EI, London WB, Castleberry R. Kretschmar CS, et al. J Clin Oncol. 2004 Oct 15;22(20):4119-26. doi: 10.1200/JCO.2004.08.174. J Clin Oncol. 2004. PMID: 15483021 Clinical Trial.
PURPOSE: Most children older than 1 year of age with metastatic neuroblastoma (NB) die despite intensive chemotherapy and bone marrow transplantation. The Pediatric Oncology Group conducted a study of paclitaxel, topotecan, and topotecan-cyclophosphami …
PURPOSE: Most children older than 1 year of age with metastatic neuroblastoma (NB) die despite intensive chemotherapy and bone mar …
Role of weekly paclitaxel in the treatment of advanced ovarian cancer.
Thomas H, Rosenberg P. Thomas H, et al. Crit Rev Oncol Hematol. 2002 Dec 27;44 Suppl:S43-51. doi: 10.1016/s1040-8428(02)00103-8. Crit Rev Oncol Hematol. 2002. PMID: 12505598 Review.
The lower doses and shorter infusion times used with weekly dosing should also minimize bone marrow suppression and other toxicities associated with standard paclitaxel 3-weekly administration. ...Such therapy has included weekly paclitaxel in combination wit …
The lower doses and shorter infusion times used with weekly dosing should also minimize bone marrow suppression and oth …
Assessment of anti-cytogenotoxic effects of quercetin in animals treated with topotecan.
Bakheet SA. Bakheet SA. Oxid Med Cell Longev. 2011;2011:824597. doi: 10.1155/2011/824597. Epub 2011 Aug 15. Oxid Med Cell Longev. 2011. PMID: 21904648 Free PMC article.
Moreover, prior administration of quercetin ahead of topotecan challenge ameliorated oxidative stress markers. In conclusion, quercetin has a protective role in the abatement of topotecan-induced cyto- and genotoxicity in the bone marrow cells of mice …
Moreover, prior administration of quercetin ahead of topotecan challenge ameliorated oxidative stress markers. In conclusion, quercet …
The druggable transcription factor Fli-1 regulates T cell immunity and tolerance in graft-versus-host disease.
Schutt SD, Wu Y, Kharel A, Bastian D, Choi HJ, Hanief Sofi M, Mealer C, McDaniel Mims B, Nguyen H, Liu C, Helke K, Cui W, Zhang X, Ben-David Y, Yu XZ. Schutt SD, et al. J Clin Invest. 2022 Nov 1;132(21):e143950. doi: 10.1172/JCI143950. J Clin Invest. 2022. PMID: 36074578 Free PMC article.
Fli-1 promoted the transcription of Th1/Th17 pathways and T cell receptor-inducible (TCR-inducible) transcription factors in CD4+ T cells, while suppressing activation- and function-related gene pathways in CD8+ T cells. Importantly, a low dose of camptothecin, topoteca …
Fli-1 promoted the transcription of Th1/Th17 pathways and T cell receptor-inducible (TCR-inducible) transcription factors in CD4+ T cells, w …
Sequential intraperitoneal topotecan and oral etoposide chemotherapy in recurrent platinum-resistant ovarian carcinoma: results of a phase II trial.
Sood AK, Lush R, Geisler JP, Shahin MS, Sanders L, Sullivan D, Buller RE, Sorosky JI. Sood AK, et al. Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6080-5. doi: 10.1158/1078-0432.CCR-04-0574. Clin Cancer Res. 2004. PMID: 15447993 Clinical Trial.
Dose reduction of topotecan was used for severe bone marrow suppression. Peritoneal (topotecan) and plasma (topotecan and etoposide) levels were assessed at multiple time points using high-pressure liquid chromatography. ...Additional stu …
Dose reduction of topotecan was used for severe bone marrow suppression. Peritoneal (topotecan) and plasm …
[Therapeutic and adverse effects of topotecan combined with cisplatin for treatment of advanced squamous cell lung cancer and head and neck cancer].
Xiang Y, Li QY, Shao JH, Yang JZ. Xiang Y, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2008 Mar;28(3):491-3. Nan Fang Yi Ke Da Xue Xue Bao. 2008. PMID: 18359722 Chinese.
OBJECTIVE: To evaluate the therapeutic and adverse effects of topotecan combined with cisplatin in the treatment of advanced squamous cell lung cancer and head and neck cancer. ...The total response rate was 48.4% among the patients, with the median survival time of 10.1 m …
OBJECTIVE: To evaluate the therapeutic and adverse effects of topotecan combined with cisplatin in the treatment of advanced squamous …
Topotecan plus cyclophosphamide as maintenance chemotherapy for children with high-risk neuroblastoma in complete remission: short-term curative effects and toxicity.
Feng C, Tang S, Wang J, Liu Y, Yang G. Feng C, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2013 Aug;33(8):1107-10. Nan Fang Yi Ke Da Xue Xue Bao. 2013. PMID: 23996746
OBJECTIVE: To evaluate chemotherapy-related toxicity and the short-term efficacy of topotecan and cyclophosphamide as maintenance chemotherapy for stage IV neuroblastoma in complete remission. ...The two-year event-free survival after complete remission was recorded and th …
OBJECTIVE: To evaluate chemotherapy-related toxicity and the short-term efficacy of topotecan and cyclophosphamide as maintenance che …
[Effect of cisplatin, topotecan, daunorubicin and hydroxyurea on human mesenchymal stem cells].
Li J, Law HK, Liu YL, Chan GC. Li J, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Aug;18(4):991-6. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010. PMID: 20723315 Chinese.
Mesenchymal stem cells (MSC) are important cellular component of the bone marrow microenvironment in supporting hemopoiesis. Li J et al reported previously that MSCs are resistant to chemotherapy commonly used in hematologic malignancies but are relatively sensitive …
Mesenchymal stem cells (MSC) are important cellular component of the bone marrow microenvironment in supporting hemopoiesis. L …
15 results