Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1982 2
1983 2
1984 6
1985 7
1986 12
1987 32
1988 39
1989 38
1990 31
1991 32
1992 26
1993 30
1994 24
1995 25
1996 22
1997 27
1998 29
1999 16
2000 14
2001 10
2002 18
2003 16
2004 6
2005 4
2006 5
2007 4
2008 3
2009 4
2010 14
2011 2
2012 3
2013 2
2014 1
2015 2
2016 4
2017 3
2018 1
2019 2
2020 1
2023 0
Text availability
Article attribute
Article type
Publication date

Search Results

515 results
Results by year
Filters applied: . Clear all
Page 1
Trimetrexate.
[No authors listed] [No authors listed] 2016 Apr 18. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2016 Apr 18. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31644074 Free Books & Documents. Review.
Trimetrexate is a parenterally administered folate antagonist that is used as a second line therapy for severe Pneumocystis jirovecii (previously carinii) pneumonia. Trimetrexate therapy has been associated with transient, mild serum enzyme elevations during therapy …
Trimetrexate is a parenterally administered folate antagonist that is used as a second line therapy for severe Pneumocystis jirovecii …
Trimetrexate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of Pneumocystis carinii pneumonia.
Fulton B, Wagstaff AJ, McTavish D. Fulton B, et al. Drugs. 1995 Apr;49(4):563-76. doi: 10.2165/00003495-199549040-00007. Drugs. 1995. PMID: 7789290 Review.
Trimetrexate is a folinic acid analogue structurally related to methotrexate, whose primary mechanism of action is believed to be inhibition of dihydrofolate reductase. ...Trimetrexate was better tolerated than cotrimoxazole when used in this setting, however. ...
Trimetrexate is a folinic acid analogue structurally related to methotrexate, whose primary mechanism of action is believed to be inh …
Trimetrexate: a second generation folate antagonist in clinical trial.
Lin JT, Bertino JR. Lin JT, et al. J Clin Oncol. 1987 Dec;5(12):2032-40. doi: 10.1200/JCO.1987.5.12.2032. J Clin Oncol. 1987. PMID: 2960788 Review.
Trimetrexate is a promising new lipophilic antifolate with antitumor and antimicrobial activity, which is currently undergoing clinical trials. ...Preliminary results of phase II trials indicate activity against breast, non-small-cell lung, and head and neck tumors. In add …
Trimetrexate is a promising new lipophilic antifolate with antitumor and antimicrobial activity, which is currently undergoing clinic …
Trimetrexate for Pneumocystis carinii pneumonia in patients with AIDS.
Amsden GW, Kowalsky SF, Morse GD. Amsden GW, et al. Ann Pharmacother. 1992 Feb;26(2):218-26. doi: 10.1177/106002809202600217. Ann Pharmacother. 1992. PMID: 1532518 Review.
OBJECTIVE: The primary objective of this article is to introduce readers to the use of a new agent, trimetrexate (TMTX), in the treatment of Pneumocystis carinii pneumonia (PCP). ...
OBJECTIVE: The primary objective of this article is to introduce readers to the use of a new agent, trimetrexate (TMTX), in the treat …
Understanding trimetrexate toxicity.
Donehower RC. Donehower RC. J Natl Cancer Inst. 1988 Oct 19;80(16):1268-9. doi: 10.1093/jnci/80.16.1268. J Natl Cancer Inst. 1988. PMID: 2971816 No abstract available.
Clinical pharmacokinetics and pharmacology of trimetrexate.
Marshall JL, DeLap RJ. Marshall JL, et al. Clin Pharmacokinet. 1994 Mar;26(3):190-200. doi: 10.2165/00003088-199426030-00003. Clin Pharmacokinet. 1994. PMID: 8194282 Review.
Trimetrexate represents one of a number of new antimetabolites that have been studied in malignant, rheumatological and infectious disease. ...However, further trials are needed to fully establish the efficacy of trimetrexate in these settings. Increased knowledge o …
Trimetrexate represents one of a number of new antimetabolites that have been studied in malignant, rheumatological and infectious di …
Treatment of Pneumocystis jirovecii pneumonia in HIV-infected patients: a review.
Huang YS, Yang JJ, Lee NY, Chen GJ, Ko WC, Sun HY, Hung CC. Huang YS, et al. Expert Rev Anti Infect Ther. 2017 Sep;15(9):873-892. doi: 10.1080/14787210.2017.1364991. Epub 2017 Aug 21. Expert Rev Anti Infect Ther. 2017. PMID: 28782390 Review.
Search terms included: 'Pneumocystis pneumonia', 'Pneumocystis jirovecii pneumonia', 'Pneumocystis carinii pneumonia', 'trimethoprim-sulfamethoxazole', 'primaquine', 'trimetrexate', 'dapsone', 'pentamidine', 'atovaquone', 'echinocandins', 'human immunodeficiency virus infe …
Search terms included: 'Pneumocystis pneumonia', 'Pneumocystis jirovecii pneumonia', 'Pneumocystis carinii pneumonia', 'trimethoprim-sulfame …
Trimetrexate: experience with solid tumors.
Haller DG. Haller DG. Semin Oncol. 1997 Oct;24(5 Suppl 18):S18-71-S18-76. Semin Oncol. 1997. PMID: 9420024 Review.
Trimetrexate (TMTX), a potent inhibitor of the enzyme dihydrofolate reductase, is biochemically and metabolically similar to methotrexate (MTX). ...
Trimetrexate (TMTX), a potent inhibitor of the enzyme dihydrofolate reductase, is biochemically and metabolically similar to methotre …
515 results