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2020 15
2021 2
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Plausible Biological Interactions of Low- and Non-Calorie Sweeteners with the Intestinal Microbiota: An Update of Recent Studies.
Plaza-Diaz J, Pastor-Villaescusa B, Rueda-Robles A, Abadia-Molina F, Ruiz-Ojeda FJ. Plaza-Diaz J, et al. Nutrients. 2020 Apr 21;12(4):1153. doi: 10.3390/nu12041153. Nutrients. 2020. PMID: 32326137 Free PMC article. Review.
The NNS aspartame and acesulfame-K do not interact with the colonic microbiota, and, as a result, potentially expected shifts in the gut microbiota are relatively limited, although acesulfame-K intake increases Firmicutes and depletes Akkermansia muciniphila populations. O …
The NNS aspartame and acesulfame-K do not interact with the colonic microbiota, and, as a result, potentially expected shifts in the gut mic …
Autophagy-dependent and -independent modulation of oxidative and organellar stress in the diabetic heart by glucose-lowering drugs.
Packer M. Packer M. Cardiovasc Diabetol. 2020 May 13;19(1):62. doi: 10.1186/s12933-020-01041-4. Cardiovasc Diabetol. 2020. PMID: 32404204 Free PMC article. Review.
Autophagy is a lysosome-dependent intracellular degradative pathway, which mediates the cellular adaptation to nutrient and oxygen depletion as well as to oxidative and endoplasmic reticulum stress. ...
Autophagy is a lysosome-dependent intracellular degradative pathway, which mediates the cellular adaptation to nutrient and oxygen …
Plain vitamin D or active vitamin D in the treatment of osteoporosis: where do we stand today?
Ringe JD. Ringe JD. Arch Osteoporos. 2020 Nov 14;15(1):182. doi: 10.1007/s11657-020-00842-0. Arch Osteoporos. 2020. PMID: 33188611 Review.
However, other factors linked directly to ageing such as oestrogen depletion, reduced kidney or liver function may also be involved in reducing the body's capability to activate plain vitamin efficiently. ...
However, other factors linked directly to ageing such as oestrogen depletion, reduced kidney or liver function may also be involved i …
Oncology Therapeutics Targeting the Metabolism of Amino Acids.
Muhammad N, Lee HM, Kim J. Muhammad N, et al. Cells. 2020 Aug 15;9(8):1904. doi: 10.3390/cells9081904. Cells. 2020. PMID: 32824193 Free PMC article. Review.
Malignant cells rewire amino acid metabolism to maximize their access to nutrients. Amino acid transporter expression is upregulated to acquire amino acids from the extracellular environment. Under nutrient depleted conditions, macropinocytosis can be activat …
Malignant cells rewire amino acid metabolism to maximize their access to nutrients. Amino acid transporter expression is upregulated …
Phytochemical Targeting of STAT3 Orchestrated Lipid Metabolism in Therapy-Resistant Cancers.
Tse C, Warner A, Farook R, Cronin JG. Tse C, et al. Biomolecules. 2020 Jul 28;10(8):1118. doi: 10.3390/biom10081118. Biomolecules. 2020. PMID: 32731620 Free PMC article. Review.
Tumours exist in a microenvironment of poor vascularization-depleted oxygen and restricted nutrients. Under these conditions, tumours have been shown to increasingly depend on the metabolism of fatty acids for sustained proliferation and survival. ...
Tumours exist in a microenvironment of poor vascularization-depleted oxygen and restricted nutrients. Under these conditions, …
The Role of Dietary Fibre in Modulating Gut Microbiota Dysbiosis in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
Ojo O, Feng QQ, Ojo OO, Wang XH. Ojo O, et al. Nutrients. 2020 Oct 23;12(11):3239. doi: 10.3390/nu12113239. Nutrients. 2020. PMID: 33113929 Free PMC article.
In particular, low intake of dietary fibre and consumption of foods high in fat and sugar, which are common in western lifestyle, have been reported to contribute to the depletion of specific bacterial taxa. Therefore, it is possible that intake of high dietary fibre may a …
In particular, low intake of dietary fibre and consumption of foods high in fat and sugar, which are common in western lifestyle, have been …
Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors.
Melick CH, Jewell JL. Melick CH, et al. Biochem J. 2020 May 29;477(10):1847-1863. doi: 10.1042/BCJ20190958. Biochem J. 2020. PMID: 32347294 Free PMC article.
As the mTOR name implies it is the target of natural product called rapamycin, a clinically approved drug used to treat human disease. Short-term rapamycin treatment inhibits the kinase activity of mTORC1 but not mTORC2. ...Moreover, H89 prevented the dephosphorylation of …
As the mTOR name implies it is the target of natural product called rapamycin, a clinically approved drug used to treat human disease …
Copper as a potential adjunct therapy for critically ill COVID-19 patients.
Fooladi S, Matin S, Mahmoodpoor A. Fooladi S, et al. Clin Nutr ESPEN. 2020 Dec;40:90-91. doi: 10.1016/j.clnesp.2020.09.022. Epub 2020 Sep 25. Clin Nutr ESPEN. 2020. PMID: 33183578 Free PMC article.
Despite its important action in physiochemical properties, only small amount of copper is presented in biological fluid, none of which presents as free ion form that readily affirms its depletion in critically ill patients. Recent studies confirmed its anti-viral capacity. …
Despite its important action in physiochemical properties, only small amount of copper is presented in biological fluid, none of which prese …
Rapid evolution of our understanding of the pathogenesis of COVID-19: Implications for therapy.
Mustafa F, Giles R, Pepper MS. Mustafa F, et al. S Afr Med J. 2020 Oct 23;110(12):1180-1185. doi: 10.7196/SAMJ.2020.v110i12.15328. S Afr Med J. 2020. PMID: 33403962 Free article. Review.
Disease severity is linked to age, sex and comorbid conditions, which in turn may be linked to oxidative stress and pre-existing depletion of nicotinamide adenine dinucleotide (NAD+). There is increasing evidence that the host genome may determine disease outcome. ...
Disease severity is linked to age, sex and comorbid conditions, which in turn may be linked to oxidative stress and pre-existing depletio
Histone lysine demethylase 3B (KDM3B) regulates the propagation of autophagy via transcriptional activation of autophagy-related genes.
Jung H, Seo SB. Jung H, et al. PLoS One. 2020 Jul 27;15(7):e0236403. doi: 10.1371/journal.pone.0236403. eCollection 2020. PLoS One. 2020. PMID: 32716961 Free PMC article.
Here, we report that the level of lysine demethylase 3B (KDM3B) increases in nutrient-deprived HCT116 cells, a colorectal carcinoma cell line, resulting in transcriptional activation of the autophagy-inducing genes. KDM3B was found to enhance the transcription by demethyla …
Here, we report that the level of lysine demethylase 3B (KDM3B) increases in nutrient-deprived HCT116 cells, a colorectal carcinoma c …
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