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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1923 1
1927 1
1930 1
1939 1
1941 3
1943 1
1944 2
1945 9
1946 19
1947 23
1948 44
1949 46
1950 51
1951 64
1952 79
1953 75
1954 70
1955 97
1956 72
1957 91
1958 80
1959 75
1960 74
1961 52
1962 76
1963 110
1964 158
1965 109
1966 102
1967 138
1968 153
1969 164
1970 183
1971 237
1972 298
1973 303
1974 381
1975 284
1976 299
1977 289
1978 309
1979 332
1980 341
1981 331
1982 373
1983 384
1984 341
1985 376
1986 367
1987 419
1988 368
1989 420
1990 373
1991 412
1992 383
1993 420
1994 386
1995 372
1996 445
1997 424
1998 456
1999 435
2000 464
2001 509
2002 487
2003 519
2004 565
2005 601
2006 614
2007 660
2008 786
2009 756
2010 896
2011 1008
2012 993
2013 1045
2014 1186
2015 1245
2016 1286
2017 1283
2018 1383
2019 1436
2020 1523
2021 10
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30,090 results
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Page 1
CRISPR/Cas9 for Sickle Cell Disease: Applications, Future Possibilities, and Challenges.
Demirci S, Leonard A, Haro-Mora JJ, Uchida N, Tisdale JF. Demirci S, et al. Adv Exp Med Biol. 2019;1144:37-52. doi: 10.1007/5584_2018_331. Adv Exp Med Biol. 2019. PMID: 30715679 Review.
Sickle cell disease (SCD) is an inherited monogenic disorder resulting in serious mortality and morbidity worldwide. ...Rapid and substantial progress in genome editing approaches have proven valuable as a curative option given plausibility to either correct the und
Sickle cell disease (SCD) is an inherited monogenic disorder resulting in serious mortality and morbidity worldwide. ...Rapid
Microparticles in sickle cell disease.
Romana M, Connes P, Key NS. Romana M, et al. Clin Hemorheol Microcirc. 2018;68(2-3):319-329. doi: 10.3233/CH-189014. Clin Hemorheol Microcirc. 2018. PMID: 29614639 Free article.
Several pathophysiological pathways in sickle cell disease (SCD), the most prevalent hemoglobinopathy worldwide, result in activation of circulating blood cells and the release of submicron vesicles, so-called microparticles (MPs). ...However, the functional …
Several pathophysiological pathways in sickle cell disease (SCD), the most prevalent hemoglobinopathy worldwide, result in act …
Highly efficient editing of the beta-globin gene in patient-derived hematopoietic stem and progenitor cells to treat sickle cell disease.
Park SH, Lee CM, Dever DP, Davis TH, Camarena J, Srifa W, Zhang Y, Paikari A, Chang AK, Porteus MH, Sheehan VA, Bao G. Park SH, et al. Nucleic Acids Res. 2019 Sep 5;47(15):7955-7972. doi: 10.1093/nar/gkz475. Nucleic Acids Res. 2019. PMID: 31147717 Free PMC article.
Sickle cell disease (SCD) is a monogenic disorder that affects millions worldwide. ...Erythrocytes derived from gene-edited cells showed a marked reduction of sickle cells, with the level of normal hemoglobin (HbA) increased to 25.3 13.9%. ...
Sickle cell disease (SCD) is a monogenic disorder that affects millions worldwide. ...Erythrocytes derived from gene-edited
Simultaneous polymerization and adhesion under hypoxia in sickle cell disease.
Papageorgiou DP, Abidi SZ, Chang HY, Li X, Kato GJ, Karniadakis GE, Suresh S, Dao M. Papageorgiou DP, et al. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9473-9478. doi: 10.1073/pnas.1807405115. Epub 2018 Sep 6. Proc Natl Acad Sci U S A. 2018. PMID: 30190429 Free PMC article.
Polymerization and adhesion, dynamic processes that are hallmarks of sickle cell disease (SCD), have thus far been studied in vitro only separately. ...We supplemented these experimental results with detailed molecular-level computational simulations of cytoadherenc …
Polymerization and adhesion, dynamic processes that are hallmarks of sickle cell disease (SCD), have thus far been studied in …
GBT440 improves red blood cell deformability and reduces viscosity of sickle cell blood under deoxygenated conditions.
Dufu K, Patel M, Oksenberg D, Cabrales P. Dufu K, et al. Clin Hemorheol Microcirc. 2018;70(1):95-105. doi: 10.3233/CH-170340. Clin Hemorheol Microcirc. 2018. PMID: 29660913 Free PMC article.
BACKGROUND: In sickle cell disease (SCD), polymerization of hemoglobin S (HbS) leads to the formation of rigid, non-deformable sickled RBCs. ...OBJECTIVE: The purpose of this study was to determine the effects of GBT440 on deformability of sickle RBCs …
BACKGROUND: In sickle cell disease (SCD), polymerization of hemoglobin S (HbS) leads to the formation of rigid, non-deformable …
Bone Marrow Transplantation In Sickle Cell Disease.
Ashorobi D, Bhatt R. Ashorobi D, et al. 2020 Jul 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. StatPearls. 2020 Jan–. PMID: 30860750 Free Books & Documents. Review.
Linus Pauling, who was a renowned scientist, carried out a landmark study in 1949 where he concluded that sickle cell disease is caused by abnormal hemoglobin that sickles once exposed to a low oxygen environment. ...A patient with only the HbS is known to ha …
Linus Pauling, who was a renowned scientist, carried out a landmark study in 1949 where he concluded that sickle cell disease …
Red blood cells modulate structure and dynamics of venous clot formation in sickle cell disease.
Faes C, Ilich A, Sotiaux A, Sparkenbaugh EM, Henderson MW, Buczek L, Beckman JD, Ellsworth P, Noubouossie DF, Bhoopat L, Piegore M, Renoux C, Bergmeier W, Park Y, Ataga KI, Cooley B, Wolberg AS, Key NS, Pawlinski R. Faes C, et al. Blood. 2019 Jun 6;133(23):2529-2541. doi: 10.1182/blood.2019000424. Epub 2019 Apr 5. Blood. 2019. PMID: 30952675 Free PMC article.
Sickle cell disease (SCD) is associated with chronic activation of coagulation and an increased risk of venous thromboembolism. ...Sickling of RBCs and a significant increase in fibrin deposition were observed in venous thrombi formed in sickle mice. .
Sickle cell disease (SCD) is associated with chronic activation of coagulation and an increased risk of venous thromboembolism
Do we have to consider acidosis induced by exercise as deleterious in sickle cell disease?
Chatel B, Messonnier LA, Bendahan D. Chatel B, et al. Exp Physiol. 2018 Sep;103(9):1213-1220. doi: 10.1113/EP087169. Epub 2018 Aug 18. Exp Physiol. 2018. PMID: 30024072 Free article. Review.
The aim of this review is to discuss the potential involvement of exercise-induced acidosis in the commonly reported complications in sickle cell disease. What advances does it highlight? Blood acidosis appears clearly to be a risk factor for HbS polymerization, red …
The aim of this review is to discuss the potential involvement of exercise-induced acidosis in the commonly reported complications in sic
GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease.
Oksenberg D, Dufu K, Patel MP, Chuang C, Li Z, Xu Q, Silva-Garcia A, Zhou C, Hutchaleelaha A, Patskovska L, Patskovsky Y, Almo SC, Sinha U, Metcalf BW, Archer DR. Oksenberg D, et al. Br J Haematol. 2016 Oct;175(1):141-53. doi: 10.1111/bjh.14214. Epub 2016 Jul 5. Br J Haematol. 2016. PMID: 27378309
A major driver of the pathophysiology of sickle cell disease (SCD) is polymerization of deoxygenated haemoglobin S (HbS), which leads to sickling and destruction of red blood cells (RBCs) and end-organ damage. ...Thus, GBT440 has the potential for clin …
A major driver of the pathophysiology of sickle cell disease (SCD) is polymerization of deoxygenated haemoglobin S (HbS), whic …
Selecting red blood cell units to perform RBCX in patients with sickle cell disease.
Raba M. Raba M. Transfus Apher Sci. 2019 Apr;58(2):142-146. doi: 10.1016/j.transci.2019.03.007. Epub 2019 Mar 13. Transfus Apher Sci. 2019. PMID: 30910616 Review.
Red blood cell exchange (RBCX) is a standard option for treating or preventing complications in patients with sickle cell disease (SCD). According to the patient's blood volume, the amounts of red blood cells (RBC) to be exchanged and the practices of …
Red blood cell exchange (RBCX) is a standard option for treating or preventing complications in patients with sickle cell
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