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4,248 results

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Page 1
Wnt1's Differential Effects on Craniofacial Bone and Tooth Development.
Mahmoud R, Simon A, Luther J, Pothe J, Du Y, Nottmeier C, Okine E, Knauth S, Lopez MG, Bockamp E, Krivanek J, LeBlanc A, Helms J, Amling M, Kaucka M, Schinke T, Koehne T, Petersen J. Mahmoud R, et al. J Dent Res. 2025 Nov;104(12):1415-1424. doi: 10.1177/00220345251336191. Epub 2025 Jun 2. J Dent Res. 2025. PMID: 40454459 Free PMC article.
Using publicly available single-cell sequencing data from the mouse incisor, we reveal Wnt1 expression across dental structures and investigate its role using a Col1a1-dependent Wnt1 transgenic mouse model. ...Importantly, osteoclastogenesis is suppressed by Wnt1 …
Using publicly available single-cell sequencing data from the mouse incisor, we reveal Wnt1 expression across dental structures and i …
Wnt1-regulated genetic networks in midbrain dopaminergic neuron development.
Wurst W, Prakash N. Wurst W, et al. J Mol Cell Biol. 2014 Feb;6(1):34-41. doi: 10.1093/jmcb/mjt046. Epub 2013 Dec 9. J Mol Cell Biol. 2014. PMID: 24326514 Free article. Review.
Researches during the last decade revealed the pivotal role of the secreted Wnt1 ligand and its signalling cascade in the generation of the dopamine-synthesizing neurons in the mammalian VM. Here, we summarize the initial and more recent findings that have unravelled sever …
Researches during the last decade revealed the pivotal role of the secreted Wnt1 ligand and its signalling cascade in the generation …
The Wnt1-Cre2 transgene is active in the male germline.
Dinsmore CJ, Ke CY, Soriano P. Dinsmore CJ, et al. Genesis. 2022 Mar;60(3):e23468. doi: 10.1002/dvg.23468. Epub 2022 Feb 18. Genesis. 2022. PMID: 35180326 Free PMC article.
The Wnt1-Cre transgenic mouse line is widely used to express the CRE recombinase in neural crest lineages, but it overexpresses WNT1 itself, which can cause undesired phenotypes. To address this, we and others previously developed a Wnt1-Cre2 line based on th …
The Wnt1-Cre transgenic mouse line is widely used to express the CRE recombinase in neural crest lineages, but it overexpresses WN …
Wnt1 Boosts Fracture Healing by Enhancing Bone Formation in the Fracture Callus.
Haffner-Luntzer M, Ragipoglu D, Ahmad M, Schoppa A, Steppe L, Fischer V, Luther J, Yorgan T, Bockamp E, Amling M, Schinke T, Ignatius A. Haffner-Luntzer M, et al. J Bone Miner Res. 2023 May;38(5):749-764. doi: 10.1002/jbmr.4797. Epub 2023 Mar 22. J Bone Miner Res. 2023. PMID: 36891752 Free article.
Transgenic mice for a temporary induction of Wnt1 specifically in osteoblasts (Wnt1-tg) were subjected to femur osteotomy. Non-ovariectomized and ovariectomized Wnt1-tg mice displayed significantly accelerated fracture healing based on a strong increase in bo …
Transgenic mice for a temporary induction of Wnt1 specifically in osteoblasts (Wnt1-tg) were subjected to femur osteotomy. Non …
Wnt1 Role in the Development of the Habenula and the Fasciculus Retroflexus.
Company V, Moreno-Cerdá A, Andreu-Cervera A, Murcia-Ramón R, Almagro-García F, Echevarría D, Martínez S, Puelles E. Company V, et al. Front Cell Dev Biol. 2021 Oct 14;9:755729. doi: 10.3389/fcell.2021.755729. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34722541 Free PMC article.
Wnt1 is one of the morphogenes that controls the specification and differentiation of neuronal populations in the developing central nervous system. ...The mid-hindbrain territories that the tract must cross were miss-differentiated in our model. The specification of the h …
Wnt1 is one of the morphogenes that controls the specification and differentiation of neuronal populations in the developing central …
Multi-omics analyses reveal aberrant differentiation trajectory with WNT1 loss-of-function in type XV osteogenesis imperfecta.
Tan Z, Chen P, Zhang J, Shek HT, Li Z, Zhou X, Zhou Y, Yin S, Dong L, Feng L, Wong JSH, Gao B, To MKT. Tan Z, et al. J Bone Miner Res. 2024 Sep 2;39(9):1253-1267. doi: 10.1093/jbmr/zjae123. J Bone Miner Res. 2024. PMID: 39126373 Free PMC article.
Type XV osteogenesis imperfect is an autosomal recessive disorder caused by WNT1 variants, while heterozygous variants of WNT1 result in early onset osteoporosis. In this cohort study, we summarized the clinical features of 25 patients diagnosed with type XV osteoge …
Type XV osteogenesis imperfect is an autosomal recessive disorder caused by WNT1 variants, while heterozygous variants of WNT1 …
One Wnt to lead them all: a Wnt1 primer.
Lekven AC, Empie S, Saoud R. Lekven AC, et al. Differentiation. 2025 Jul-Aug;144:100884. doi: 10.1016/j.diff.2025.100884. Epub 2025 Jun 24. Differentiation. 2025. PMID: 40580644 Review.
Wnt1 was originally identified by virtue of its mutant phenotype in Drosophila and its causation of mammary tumors in mice, but, in its history, Wnt1 has been a nexus for ground-breaking discoveries in developmental biology, evolutionary biology, and disease. ... …
Wnt1 was originally identified by virtue of its mutant phenotype in Drosophila and its causation of mammary tumors in mice, but, in i …
Analysis of the wnt1 regulatory chromosomal landscape.
Lekven AC, Lilie CJ, Gibbs HC, Green DG, Singh A, Yeh AT. Lekven AC, et al. Dev Genes Evol. 2019 May;229(2-3):43-52. doi: 10.1007/s00427-019-00629-5. Epub 2019 Mar 1. Dev Genes Evol. 2019. PMID: 30825002 Free PMC article.
To understand wnt1 and wnt10b transcriptional control, we used a comparative genomics approach to identify relevant enhancers. We show that the wnt1-wnt10b locus contains multiple cis-regulatory elements that likely interact to generate the wnt1 and wnt10b ex …
To understand wnt1 and wnt10b transcriptional control, we used a comparative genomics approach to identify relevant enhancers. We sho …
Mechanical induction of osteoanabolic Wnt1 promotes osteoblast differentiation via Plat.
Ahmad M, Haffner-Luntzer M, Schoppa A, Najafova Z, Lukic T, Yorgan TA, Amling M, Schinke T, Ignatius A. Ahmad M, et al. FASEB J. 2024 Feb 29;38(4):e23489. doi: 10.1096/fj.202301424RR. FASEB J. 2024. PMID: 38407813
Here, we found that mechanical stimulation induces osteoblastic Wnt1 expression, resulting in an upregulation of key osteogenic marker genes, including Runx2 and Sp7, while Wnt1 knockdown using siRNA prevented these effects. ...Furthermore, our findings showed that …
Here, we found that mechanical stimulation induces osteoblastic Wnt1 expression, resulting in an upregulation of key osteogenic marke …
Osteoblastic Wnt1 regulates periosteal bone formation in adult mice.
Wang F, Rummukainen P, Heino TJ, Kiviranta R. Wang F, et al. Bone. 2021 Feb;143:115754. doi: 10.1016/j.bone.2020.115754. Epub 2020 Nov 13. Bone. 2021. PMID: 33189914 Free article.
However, the function of Wnt1 in mature skeleton remained unknown. To investigate the role of Wnt1 specifically in adult bone metabolism, we generated an osteoblast lineage-targeted inducible Wnt1 knockout mouse model using tetracycline-controlled Osterix-Cre …
However, the function of Wnt1 in mature skeleton remained unknown. To investigate the role of Wnt1 specifically in adult bone …
4,248 results