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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
1988 3
1989 8
1990 9
1991 12
1992 24
1993 37
1994 63
1995 62
1996 76
1997 86
1998 95
1999 108
2000 109
2001 95
2002 110
2003 89
2004 102
2005 113
2006 114
2007 123
2008 168
2009 137
2010 135
2011 162
2012 163
2013 182
2014 165
2015 178
2016 162
2017 182
2018 207
2019 236
2020 251
2021 210
2022 137
2023 17
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3,764 results
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Page 1
Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/β-catenin signaling pathway in cervical cancer.
Xu T, Zeng Y, Shi L, Yang Q, Chen Y, Wu G, Li G, Xu S. Xu T, et al. J Exp Clin Cancer Res. 2020 Sep 10;39(1):183. doi: 10.1186/s13046-020-01659-y. J Exp Clin Cancer Res. 2020. PMID: 32907622 Free PMC article.
Furthermore, we provided evidence that depletion of NEK2 impairs oncogenesis and enhances radiosensitivity in cervical cancer. Using RNA sequencing, we identify Wnt1 as a key downstream effector of NEK2. Knockdown of NEK2 downregulates the mRNA and protein levels of Wnt …
Furthermore, we provided evidence that depletion of NEK2 impairs oncogenesis and enhances radiosensitivity in cervical cancer. Using RNA seq …
The Wnt1-Cre2 transgene is active in the male germline.
Dinsmore CJ, Ke CY, Soriano P. Dinsmore CJ, et al. Genesis. 2022 Mar;60(3):e23468. doi: 10.1002/dvg.23468. Epub 2022 Feb 18. Genesis. 2022. PMID: 35180326
The Wnt1-Cre transgenic mouse line is widely used to express the CRE recombinase in neural crest lineages, but it overexpresses WNT1 itself, which can cause undesired phenotypes. To address this, we and others previously developed a Wnt1-Cre2 line based on th …
The Wnt1-Cre transgenic mouse line is widely used to express the CRE recombinase in neural crest lineages, but it overexpresses WN …
Wnt1 Role in the Development of the Habenula and the Fasciculus Retroflexus.
Company V, Moreno-Cerdá A, Andreu-Cervera A, Murcia-Ramón R, Almagro-García F, Echevarría D, Martínez S, Puelles E. Company V, et al. Front Cell Dev Biol. 2021 Oct 14;9:755729. doi: 10.3389/fcell.2021.755729. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34722541 Free PMC article.
Wnt1 is one of the morphogenes that controls the specification and differentiation of neuronal populations in the developing central nervous system. ...Wnt1 expressed in the isthmic organizer is vital to induce the midbrain and rostral hindbrain territories. ...
Wnt1 is one of the morphogenes that controls the specification and differentiation of neuronal populations in the developing central …
Osteoblastic Wnt1 regulates periosteal bone formation in adult mice.
Wang F, Rummukainen P, Heino TJ, Kiviranta R. Wang F, et al. Bone. 2021 Feb;143:115754. doi: 10.1016/j.bone.2020.115754. Epub 2020 Nov 13. Bone. 2021. PMID: 33189914 Free article.
However, the function of Wnt1 in mature skeleton remained unknown. To investigate the role of Wnt1 specifically in adult bone metabolism, we generated an osteoblast lineage-targeted inducible Wnt1 knockout mouse model using tetracycline-controlled Osterix-Cre …
However, the function of Wnt1 in mature skeleton remained unknown. To investigate the role of Wnt1 specifically in adult bone …
Wnt1 Promotes Cementum and Alveolar Bone Growth in a Time-Dependent Manner.
Nottmeier C, Liao N, Simon A, Decker MG, Luther J, Schweizer M, Yorgan T, Kaucka M, Bockamp E, Kahl-Nieke B, Amling M, Schinke T, Petersen J, Koehne T. Nottmeier C, et al. J Dent Res. 2021 Dec;100(13):1501-1509. doi: 10.1177/00220345211012386. Epub 2021 May 19. J Dent Res. 2021. PMID: 34009051 Free PMC article.
Micro-computed tomography (CT) analyses of the mandibles revealed a 1.8-fold increased bone volume after 1 and 3 wk of Wnt1 expression and a 3-fold increased bone volume after 9 wk of Wnt1 expression compared to controls. ...To further investigate the effect of W …
Micro-computed tomography (CT) analyses of the mandibles revealed a 1.8-fold increased bone volume after 1 and 3 wk of Wnt1 expressio …
WNT1 expression influences the development of dysplasia of the hip via regulating RBPMS2/NOG-BMP2/4-GDF5- WISP2 pathway.
Xu J, Ye W, Li H, Xu L. Xu J, et al. Nucleosides Nucleotides Nucleic Acids. 2022;41(8):765-777. doi: 10.1080/15257770.2022.2081337. Epub 2022 Jun 8. Nucleosides Nucleotides Nucleic Acids. 2022. PMID: 35675541
In chondrocytes, knockdown of WNT1 upregulated NOG expression, while overexpression of WNT1 downregulated its expression. ...Therefore, WNT1 may be a new therapeutic target for DDH....
In chondrocytes, knockdown of WNT1 upregulated NOG expression, while overexpression of WNT1 downregulated its expression. ...T …
Wnt1-regulated genetic networks in midbrain dopaminergic neuron development.
Wurst W, Prakash N. Wurst W, et al. J Mol Cell Biol. 2014 Feb;6(1):34-41. doi: 10.1093/jmcb/mjt046. Epub 2013 Dec 9. J Mol Cell Biol. 2014. PMID: 24326514 Review.
Researches during the last decade revealed the pivotal role of the secreted Wnt1 ligand and its signalling cascade in the generation of the dopamine-synthesizing neurons in the mammalian VM. Here, we summarize the initial and more recent findings that have unravelled sever …
Researches during the last decade revealed the pivotal role of the secreted Wnt1 ligand and its signalling cascade in the generation …
Expression of WNT1 in ameloblastoma and its significance.
Wang GN, Zhong M, Chen Y, Ji J, Gao XQ, Wang TF. Wang GN, et al. Oncol Lett. 2018 Aug;16(2):1507-1512. doi: 10.3892/ol.2018.8820. Epub 2018 May 25. Oncol Lett. 2018. PMID: 30008830 Free PMC article.
Ectopic cytoplasmic expression of WNT1 was detected in AB; 88.8% (71/80) of the samples were WNT1-positive. ...This indicates that WNT1 may serve an important role in AB occurrence and development....
Ectopic cytoplasmic expression of WNT1 was detected in AB; 88.8% (71/80) of the samples were WNT1-positive. ...This indicates …
Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand.
Luther J, Yorgan TA, Rolvien T, Ulsamer L, Koehne T, Liao N, Keller D, Vollersen N, Teufel S, Neven M, Peters S, Schweizer M, Trumpp A, Rosigkeit S, Bockamp E, Mundlos S, Kornak U, Oheim R, Amling M, Schinke T, David JP. Luther J, et al. Sci Transl Med. 2018 Nov 7;10(466):eaau7137. doi: 10.1126/scitranslmed.aau7137. Sci Transl Med. 2018. PMID: 30404864
WNT1 mutations in humans are associated with a new form of osteogenesis imperfecta and with early-onset osteoporosis, suggesting a key role of WNT1 in bone mass regulation. ...The identification of Wnt1 as a regulator of bone formation and remodeling provides …
WNT1 mutations in humans are associated with a new form of osteogenesis imperfecta and with early-onset osteoporosis, suggesting a ke …
Lipocalin-2 is associated with FGF23 in WNT1 and PLS3 osteoporosis.
Loid P, Hauta-Alus H, Mäkitie O, Magnusson P, Mäkitie RE. Loid P, et al. Front Endocrinol (Lausanne). 2022 Sep 8;13:954730. doi: 10.3389/fendo.2022.954730. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36157448 Free PMC article.
RESULTS: We found no differences in plasma lipocalin-2 levels in WNT1 or PLS3 patients compared with MN subjects. However, lipocalin-2 was associated with C-terminal FGF23 in WNT1 patients (r=0.62; p=0.008) and PLS3 patients (r=0.63, p=0.017), and with intact FGF23 …
RESULTS: We found no differences in plasma lipocalin-2 levels in WNT1 or PLS3 patients compared with MN subjects. However, lipocalin- …
3,764 results

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