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Year Number of Results
1994 2
1995 2
1996 57
1997 70
1998 163
1999 212
2000 340
2001 394
2002 479
2003 534
2004 737
2005 825
2006 950
2007 969
2008 1122
2009 1304
2010 1602
2011 1749
2012 1922
2013 1959
2014 1935
2015 1978
2016 2092
2017 2281
2018 2356
2019 2463
2020 2802
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2022 2676
2023 2749
2024 3003
2025 3491
2026 2038

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42,733 results

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Page 1
Amyloid-beta-targeting immunotherapies for Alzheimer's disease.
Jin Y, Du Q, Song M, Kang R, Zhou J, Zhang H, Ding Y. Jin Y, et al. J Control Release. 2024 Nov;375:346-365. doi: 10.1016/j.jconrel.2024.09.012. Epub 2024 Sep 18. J Control Release. 2024. PMID: 39271059 Review.
Recent advances in clinical passive immunotherapy have provided compelling evidence that eliminating amyloid-beta (Abeta) slows cognitive decline in Alzheimer's disease (AD). However, the modest benefits and side effects observed in clinical trials indicate t …
Recent advances in clinical passive immunotherapy have provided compelling evidence that eliminating amyloid-beta (Abeta …
beta-Amyloids and Immune Responses Associated with Alzheimer's Disease.
Kolobova E, Petrushanko I, Mitkevich V, Makarov AA, Grigorova IL. Kolobova E, et al. Cells. 2024 Sep 28;13(19):1624. doi: 10.3390/cells13191624. Cells. 2024. PMID: 39404388 Free PMC article. Review.
Alzheimer's disease (AD) is associated with the accumulation of beta-amyloids (Abetas) and the formation of Abeta plaques in the brain. Various structural forms and isoforms of Abetas that have variable propensities for oligomerization and toxicity and …
Alzheimer's disease (AD) is associated with the accumulation of beta-amyloids (Abetas) and the formation of Abeta plaqu …
Intracellular A-beta amyloid, a sign for worse things to come?
Echeverria V, Cuello AC. Echeverria V, et al. Mol Neurobiol. 2002 Oct-Dec;26(2-3):299-316. doi: 10.1385/MN:26:2-3:299. Mol Neurobiol. 2002. PMID: 12428762 Review.
In this review the authors discuss the possible neuropathological role of intracellular amyloid-beta accumulation in Alzheimer's disease (AD) pathology. There is abundant evidence that at early stages of the disease, prior to A-beta amyloid plaque form …
In this review the authors discuss the possible neuropathological role of intracellular amyloid-beta accumulation in Alzheimer …
beta-Amyloid Is a Kinocidin Cytokine.
Weaver DF. Weaver DF. ACS Chem Neurosci. 2024 May 15;15(10):1948-1950. doi: 10.1021/acschemneuro.4c00236. Epub 2024 Apr 29. ACS Chem Neurosci. 2024. PMID: 38684014
Although beta-amyloid (Abeta) has long been studied as a key contributor to the pathology of Alzheimer's disease (AD), its physiological role (if any) remains undetermined. This Viewpoint highlights the evolving concept that if AD is an immunopathic di …
Although beta-amyloid (Abeta) has long been studied as a key contributor to the pathology of Alzheimer's disease …
alpha-synuclein-assisted oligomerization of beta-amyloid (1-42).
Chau E, Kim JR. Chau E, et al. Arch Biochem Biophys. 2022 Mar 15;717:109120. doi: 10.1016/j.abb.2022.109120. Epub 2022 Jan 15. Arch Biochem Biophys. 2022. PMID: 35041853 Free PMC article.
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common neurodegenerative disorders, characterized by aggregation of amyloid polypeptides, beta-amyloid (Abeta) and alpha-synuclein (alphaS), respectively. ...Among the various Ab …
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common neurodegenerative disorders, characterized by aggregation of …
The underexplored question of beta-amyloid monomers.
Copani A. Copani A. Eur J Pharmacol. 2017 Dec 15;817:71-75. doi: 10.1016/j.ejphar.2017.05.057. Epub 2017 May 31. Eur J Pharmacol. 2017. PMID: 28577967 Review.
Conceived more than 25 years ago, the amyloid cascade hypothesis of Alzheimer's disease has evolved to accommodate new findings, namely different forms of beta-amyloid aggregates and downstream dysfunctions. Yet, the cascade does not mention its very beginnin …
Conceived more than 25 years ago, the amyloid cascade hypothesis of Alzheimer's disease has evolved to accommodate new findings, name …
Negative Regulation of Cathepsins by beta-Amyloid.
Lundin B, Comby AC, Berezovska O, Maesako M. Lundin B, et al. eNeuro. 2024 Jan 10;11(1):ENEURO.0258-23.2023. doi: 10.1523/ENEURO.0258-23.2023. Print 2024 Jan. eNeuro. 2024. PMID: 38199815 Free PMC article.
Furthermore, we and others reported that the amyloid precursor protein (APP) C99 is predominantly processed by gamma-secretase in the endo-lysosomal compartments, and beta-amyloid (Abeta) peptides are enriched in the same subcellular loci. ...Taken tog …
Furthermore, we and others reported that the amyloid precursor protein (APP) C99 is predominantly processed by gamma-secretase in the …
Electrochemical Analysis in Studying beta-Amyloid Aggregation.
Suprun EV, Radko SP, Kozin SA, Mitkevich VA, Makarov AA. Suprun EV, et al. Biochemistry (Mosc). 2023 Jan;88(Suppl 1):S88-S104. doi: 10.1134/S0006297923140067. Biochemistry (Mosc). 2023. PMID: 37069116 Review.
beta-amyloid (Abeta) is comprised of a group of peptides formed as a result of cleavage of the amyloid precursor protein by secretases. ...The Abeta oxidation signal disappears, when the peptide is included in the aggregate. The advantages and d …
beta-amyloid (Abeta) is comprised of a group of peptides formed as a result of cleavage of the amyloid precursor …
beta-Amyloid peptides and amyloid plaques in Alzheimer's disease.
Gouras GK, Olsson TT, Hansson O. Gouras GK, et al. Neurotherapeutics. 2015 Jan;12(1):3-11. doi: 10.1007/s13311-014-0313-y. Neurotherapeutics. 2015. PMID: 25371168 Free PMC article. Review.
Many lines of evidence support that beta-amyloid (Abeta) peptides play an important role in Alzheimer's disease (AD), the most common cause of dementia. ...Thus, doubts have been growing about the role of Abeta as a therapeutic target. Here we review e …
Many lines of evidence support that beta-amyloid (Abeta) peptides play an important role in Alzheimer's disease (AD), t …
Amyloid beta and postoperative delirium: partners in crime or strangers in the dark?
Reekes TH, Devinney MJ, Berger M. Reekes TH, et al. Br J Anaesth. 2023 Aug;131(2):205-208. doi: 10.1016/j.bja.2023.05.009. Epub 2023 Jun 15. Br J Anaesth. 2023. PMID: 37330308 Free article.
A recent study evaluating postoperative changes in plasma beta amyloid (Abeta) levels found increased Abeta across the postoperative period, but the association with postoperative delirium incidence and severity was variable. ...
A recent study evaluating postoperative changes in plasma beta amyloid (Abeta) levels found increased Abeta acro …
42,733 results
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