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Mitochondria, oxidants, and aging.
Balaban RS, Nemoto S, Finkel T. Balaban RS, et al. Cell. 2005 Feb 25;120(4):483-95. doi: 10.1016/j.cell.2005.02.001. Cell. 2005. PMID: 15734681 Free article. Review.
The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span. ...Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between …
The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of …
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity.
Schieke SM, Phillips D, McCoy JP Jr, Aponte AM, Shen RF, Balaban RS, Finkel T. Schieke SM, et al. Among authors: balaban rs. J Biol Chem. 2006 Sep 15;281(37):27643-52. doi: 10.1074/jbc.M603536200. Epub 2006 Jul 17. J Biol Chem. 2006. PMID: 16847060 Free article.
Metabolic rate and the subsequent production of reactive oxygen species are thought to contribute to the rate of aging in a wide range of species. The target of rapamycin (TOR) is a well conserved serine/threonine kinase that regulates cell growth in response to nutrient s …
Metabolic rate and the subsequent production of reactive oxygen species are thought to contribute to the rate of aging in a wide rang …