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The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.
Bingol B, Tea JS, Phu L, Reichelt M, Bakalarski CE, Song Q, Foreman O, Kirkpatrick DS, Sheng M. Bingol B, et al. Nature. 2014 Jun 19;510(7505):370-5. doi: 10.1038/nature13418. Epub 2014 Jun 4. Nature. 2014. PMID: 24896179
Cells maintain healthy mitochondria by degrading damaged mitochondria through mitophagy; defective mitophagy is linked to Parkinson's disease. ...Parkin ubiquitinates and tags damaged mitochondria for clearance. Overexpression of USP30 re …
Cells maintain healthy mitochondria by degrading damaged mitochondria through mitophagy; defective mitophagy is …
Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond.
Bingol B, Sheng M. Bingol B, et al. Free Radic Biol Med. 2016 Nov;100:210-222. doi: 10.1016/j.freeradbiomed.2016.04.015. Epub 2016 Apr 16. Free Radic Biol Med. 2016. PMID: 27094585 Review.
Two Parkinson's disease genes, mitochondrial kinase PINK1 and ubiquitin ligase Parkin, degrade damaged mitochondria though mitophagy. ...USP30 deubiquitinase acts as a brake on mitophagy by opposing Parkin-mediated ub …
Two Parkinson's disease genes, mitochondrial kinase PINK1 and ubiquitin ligase Parkin, degrade damaged mitochondria though …