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The role of mitochondria in aging.
Bratic A, Larsson NG. Bratic A, et al. J Clin Invest. 2013 Mar;123(3):951-7. doi: 10.1172/JCI64125. Epub 2013 Mar 1. J Clin Invest. 2013. PMID: 23454757 Free PMC article. Review.
Over the last decade, accumulating evidence has suggested a causative link between mitochondrial dysfunction and major phenotypes associated with aging. Somatic mitochondrial DNA (mtDNA) mutations and respiratory chain dysfunction accompany normal aging, but the fir …
Over the last decade, accumulating evidence has suggested a causative link between mitochondrial dysfunction and major phenotypes associated …
COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation.
Pérez-Pérez R, Lobo-Jarne T, Milenkovic D, Mourier A, Bratic A, García-Bartolomé A, Fernández-Vizarra E, Cadenas S, Delmiro A, García-Consuegra I, Arenas J, Martín MA, Larsson NG, Ugalde C. Pérez-Pérez R, et al. Among authors: bratic a. Cell Rep. 2016 Aug 30;16(9):2387-98. doi: 10.1016/j.celrep.2016.07.081. Epub 2016 Aug 18. Cell Rep. 2016. PMID: 27545886 Free PMC article.
While COX7A2L was originally described as a supercomplex-specific factor responsible for the dynamic association of complex IV into these structures to adapt MRC function to metabolic variations, this role has been disputed. Here, we further examine the functional signific …
While COX7A2L was originally described as a supercomplex-specific factor responsible for the dynamic association of complex IV into these st …
MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals.
Wredenberg A, Lagouge M, Bratic A, Metodiev MD, Spåhr H, Mourier A, Freyer C, Ruzzenente B, Tain L, Grönke S, Baggio F, Kukat C, Kremmer E, Wibom R, Polosa PL, Habermann B, Partridge L, Park CB, Larsson NG. Wredenberg A, et al. Among authors: bratic a. PLoS Genet. 2013;9(1):e1003178. doi: 10.1371/journal.pgen.1003178. Epub 2013 Jan 3. PLoS Genet. 2013. PMID: 23300484 Free PMC article.
Regulation of mitochondrial DNA (mtDNA) expression is critical for the control of oxidative phosphorylation in response to physiological demand, and this regulation is often impaired in disease and aging. We have previously shown that mitochondrial transcription terminatio …
Regulation of mitochondrial DNA (mtDNA) expression is critical for the control of oxidative phosphorylation in response to physiological dem …
Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation.
Baggio F, Bratic A, Mourier A, Kauppila TE, Tain LS, Kukat C, Habermann B, Partridge L, Larsson NG. Baggio F, et al. Among authors: bratic a. Nucleic Acids Res. 2014 Dec 16;42(22):13920-38. doi: 10.1093/nar/gku1132. Epub 2014 Nov 26. Nucleic Acids Res. 2014. PMID: 25428350 Free PMC article.
Members of the pentatricopeptide repeat domain (PPR) protein family bind RNA and are important for post-transcriptional control of organelle gene expression in unicellular eukaryotes, metazoans and plants. They also have a role in human pathology, as mutations in the leuci …
Members of the pentatricopeptide repeat domain (PPR) protein family bind RNA and are important for post-transcriptional control of organelle …