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2011 2
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2014 6
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2018 7
2019 14
2020 10
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2023 9
2024 11

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Frailty in elderly people.
Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Clegg A, et al. Lancet. 2013 Mar 2;381(9868):752-62. doi: 10.1016/S0140-6736(12)62167-9. Epub 2013 Feb 8. Lancet. 2013. PMID: 23395245 Free PMC article. Review.
In landmark studies, investigators have developed valid models of frailty and these models have allowed epidemiological investigations that show the association between frailty and adverse health outcomes. ...Such progress would greatly inform the appropriate select …
In landmark studies, investigators have developed valid models of frailty and these models have allowed epidemiological investigation …
The prevalence and outcomes of frailty in older cancer patients: a systematic review.
Handforth C, Clegg A, Young C, Simpkins S, Seymour MT, Selby PJ, Young J. Handforth C, et al. Among authors: clegg a. Ann Oncol. 2015 Jun;26(6):1091-1101. doi: 10.1093/annonc/mdu540. Epub 2014 Nov 17. Ann Oncol. 2015. PMID: 25403592 Free article. Review.
Better knowledge of the epidemiology of frailty could help drive a global cancer care strategy for older people. The aim of this review was to establish the prevalence and outcomes of frailty and pre-frailty in older cancer patients. ...There was evide …
Better knowledge of the epidemiology of frailty could help drive a global cancer care strategy for older people. The aim of th …
Frailty and the endocrine system.
Clegg A, Hassan-Smith Z. Clegg A, et al. Lancet Diabetes Endocrinol. 2018 Sep;6(9):743-752. doi: 10.1016/S2213-8587(18)30110-4. Epub 2018 Jul 17. Lancet Diabetes Endocrinol. 2018. PMID: 30017798 Free article. Review.
Frailty is a condition characterised by loss of biological reserves, failure of homoeostatic mechanisms, and vulnerability to adverse outcomes. ...Evidence also indicates a potential role for vitamin D and insulin resistance in the pathogenesis of frailty. The role …
Frailty is a condition characterised by loss of biological reserves, failure of homoeostatic mechanisms, and vulnerability to adverse …
Prevalence of frailty in 62 countries across the world: a systematic review and meta-analysis of population-level studies.
O'Caoimh R, Sezgin D, O'Donovan MR, Molloy DW, Clegg A, Rockwood K, Liew A. O'Caoimh R, et al. Among authors: clegg a. Age Ageing. 2021 Jan 8;50(1):96-104. doi: 10.1093/ageing/afaa219. Age Ageing. 2021. PMID: 33068107
Pooled prevalence in studies using physical frailty measures was 12% (95% CI = 11-13%; n = 178), compared with 24% (95% CI = 22-26%; n = 71) for the deficit accumulation model (those using a frailty index, FI). For pre-frailty, this was 46% (95% CI = 45-48%; …
Pooled prevalence in studies using physical frailty measures was 12% (95% CI = 11-13%; n = 178), compared with 24% (95% CI = 22-26%; …
Development and validation of an electronic frailty index using routine primary care electronic health record data.
Clegg A, Bates C, Young J, Ryan R, Nichols L, Ann Teale E, Mohammed MA, Parry J, Marshall T. Clegg A, et al. Age Ageing. 2016 May;45(3):353-60. doi: 10.1093/ageing/afw039. Epub 2016 Mar 3. Age Ageing. 2016. PMID: 26944937 Free PMC article.
One-year adjusted HR for mortality was 1.92 (95% CI 1.81-2.04) for mild frailty, 3.10 (95% CI 2.91-3.31) for moderate frailty and 4.52 (95% CI 4.16-4.91) for severe frailty. ...CONCLUSIONS: the eFI uses routine data to identify older people with mild, …
One-year adjusted HR for mortality was 1.92 (95% CI 1.81-2.04) for mild frailty, 3.10 (95% CI 2.91-3.31) for moderate frailty …
Community based complex interventions to sustain independence in older people: systematic review and network meta-analysis.
Crocker TF, Ensor J, Lam N, Jordão M, Bajpai R, Bond M, Forster A, Riley RD, Andre D, Brundle C, Ellwood A, Green J, Hale M, Mirza L, Morgan J, Patel I, Patetsini E, Prescott M, Ramiz R, Todd O, Walford R, Gladman J, Clegg A. Crocker TF, et al. Among authors: clegg a. BMJ. 2024 Mar 21;384:e077764. doi: 10.1136/bmj-2023-077764. BMJ. 2024. PMID: 38514079 Free PMC article.
ELIGIBILITY CRITERIA: Randomised controlled trials or cluster randomised controlled trials with 24 weeks' follow-up studying community based complex interventions for sustaining independence in older people (mean age 65 years) living at home, with usual care, placebo, or a …
ELIGIBILITY CRITERIA: Randomised controlled trials or cluster randomised controlled trials with 24 weeks' follow-up studying community based …
Frailty and acute coronary syndrome: A structured literature review.
Bebb O, Smith FG, Clegg A, Hall M, Gale CP. Bebb O, et al. Among authors: clegg a. Eur Heart J Acute Cardiovasc Care. 2018 Mar;7(2):166-175. doi: 10.1177/2048872617700873. Epub 2017 Mar 20. Eur Heart J Acute Cardiovasc Care. 2018. PMID: 29064267 Free PMC article. Review.
Older people with frailty were significantly less likely to receive guideline-indicated ACS care, including percutaneous coronary intervention (PCI) (rates ranged from 6.7% to 43.7% vs. from 30.4% to 69.5%). ...Further research is warranted in order to investigate m …
Older people with frailty were significantly less likely to receive guideline-indicated ACS care, including percutaneous coron …
Reducing delayed transfer of care in older people: A qualitative study of barriers and facilitators to shorter hospital stays.
Smith H, Grindey C, Hague I, Newbould L, Brown L, Clegg A, Thompson C, Lawton R. Smith H, et al. Among authors: clegg a. Health Expect. 2022 Dec;25(6):2628-2644. doi: 10.1111/hex.13588. Epub 2022 Oct 3. Health Expect. 2022. PMID: 36193616 Free PMC article. Review.
To identify barriers to, and facilitators of, shorter hospital stays, we sought to understand older people's and caregivers' thoughts and feelings about the benefits and harms of being in hospital and the decisions made at discharge. ...Content analysis was carried …
To identify barriers to, and facilitators of, shorter hospital stays, we sought to understand older people's and caregivers' t …
Atrial fibrillation and oral anticoagulation in older people with frailty: a nationwide primary care electronic health records cohort study.
Wilkinson C, Clegg A, Todd O, Rockwood K, Yadegarfar ME, Gale CP, Hall M. Wilkinson C, et al. Among authors: clegg a. Age Ageing. 2021 May 5;50(3):772-779. doi: 10.1093/ageing/afaa265. Age Ageing. 2021. PMID: 33951158 Free PMC article.
Frailty also increases with increasing age, yet the extent of OAC prescription in older people according to extent of frailty in people with AF is insufficiently described. ...CONCLUSION: Among older people in England, AF and stroke risk increas …
Frailty also increases with increasing age, yet the extent of OAC prescription in older people according to extent of frail …
Diagnostic test accuracy of simple instruments for identifying frailty in community-dwelling older people: a systematic review.
Clegg A, Rogers L, Young J. Clegg A, et al. Age Ageing. 2015 Jan;44(1):148-52. doi: 10.1093/ageing/afu157. Epub 2014 Oct 29. Age Ageing. 2015. PMID: 25355618 Review.
This systematic review investigates the diagnostic test accuracy (DTA) of simple instruments for identifying frailty in community-dwelling older people. METHODS: the review methodology followed Cochrane procedures. ...Prospective studies assessing the DTA of simple …
This systematic review investigates the diagnostic test accuracy (DTA) of simple instruments for identifying frailty in community-dwe …
88 results