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Frailty in elderly people.
Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Clegg A, et al. Lancet. 2013 Mar 2;381(9868):752-62. doi: 10.1016/S0140-6736(12)62167-9. Epub 2013 Feb 8. Lancet. 2013. PMID: 23395245 Free PMC article. Review.
In landmark studies, investigators have developed valid models of frailty and these models have allowed epidemiological investigations that show the association between frailty and adverse health outcomes. ...Such progress would greatly inform the appropriate select …
In landmark studies, investigators have developed valid models of frailty and these models have allowed epidemiological investigation …
Prevalence of frailty in 62 countries across the world: a systematic review and meta-analysis of population-level studies.
O'Caoimh R, Sezgin D, O'Donovan MR, Molloy DW, Clegg A, Rockwood K, Liew A. O'Caoimh R, et al. Among authors: clegg a. Age Ageing. 2021 Jan 8;50(1):96-104. doi: 10.1093/ageing/afaa219. Age Ageing. 2021. PMID: 33068107
Pooled prevalence in studies using physical frailty measures was 12% (95% CI = 11-13%; n = 178), compared with 24% (95% CI = 22-26%; n = 71) for the deficit accumulation model (those using a frailty index, FI). For pre-frailty, this was 46% (95% CI = 45-48%; …
Pooled prevalence in studies using physical frailty measures was 12% (95% CI = 11-13%; n = 178), compared with 24% (95% CI = 22-26%; …
The prevalence and outcomes of frailty in older cancer patients: a systematic review.
Handforth C, Clegg A, Young C, Simpkins S, Seymour MT, Selby PJ, Young J. Handforth C, et al. Among authors: clegg a. Ann Oncol. 2015 Jun;26(6):1091-1101. doi: 10.1093/annonc/mdu540. Epub 2014 Nov 17. Ann Oncol. 2015. PMID: 25403592 Free article.
Better knowledge of the epidemiology of frailty could help drive a global cancer care strategy for older people. The aim of this review was to establish the prevalence and outcomes of frailty and pre-frailty in older cancer patients. ...There was evide …
Better knowledge of the epidemiology of frailty could help drive a global cancer care strategy for older people. The aim of th …
Community-based complex interventions to sustain independence in older people, stratified by frailty: a systematic review and network meta-analysis.
Crocker TF, Lam N, Ensor J, Jordão M, Bajpai R, Bond M, Forster A, Riley RD, Andre D, Brundle C, Ellwood A, Green J, Hale M, Morgan J, Patetsini E, Prescott M, Ramiz R, Todd O, Walford R, Gladman J, Clegg A. Crocker TF, et al. Among authors: clegg a. Health Technol Assess. 2024 Aug;28(48):1-194. doi: 10.3310/HNRP2514. Health Technol Assess. 2024. PMID: 39252602 Free PMC article.
OBJECTIVES: To synthesise evidence of the effectiveness of community services to sustain independence for older people grouped according to their intervention components, and to examine if frailty moderates the effect. ...These often aim to help older people …
OBJECTIVES: To synthesise evidence of the effectiveness of community services to sustain independence for older people grouped accord …
Frailty and the endocrine system.
Clegg A, Hassan-Smith Z. Clegg A, et al. Lancet Diabetes Endocrinol. 2018 Sep;6(9):743-752. doi: 10.1016/S2213-8587(18)30110-4. Epub 2018 Jul 17. Lancet Diabetes Endocrinol. 2018. PMID: 30017798 Free article. Review.
Frailty is a condition characterised by loss of biological reserves, failure of homoeostatic mechanisms, and vulnerability to adverse outcomes. ...Evidence also indicates a potential role for vitamin D and insulin resistance in the pathogenesis of frailty. The role …
Frailty is a condition characterised by loss of biological reserves, failure of homoeostatic mechanisms, and vulnerability to adverse …
Development and validation of an electronic frailty index using routine primary care electronic health record data.
Clegg A, Bates C, Young J, Ryan R, Nichols L, Ann Teale E, Mohammed MA, Parry J, Marshall T. Clegg A, et al. Age Ageing. 2016 May;45(3):353-60. doi: 10.1093/ageing/afw039. Epub 2016 Mar 3. Age Ageing. 2016. PMID: 26944937 Free PMC article.
One-year adjusted HR for mortality was 1.92 (95% CI 1.81-2.04) for mild frailty, 3.10 (95% CI 2.91-3.31) for moderate frailty and 4.52 (95% CI 4.16-4.91) for severe frailty. ...CONCLUSIONS: the eFI uses routine data to identify older people with mild, …
One-year adjusted HR for mortality was 1.92 (95% CI 1.81-2.04) for mild frailty, 3.10 (95% CI 2.91-3.31) for moderate frailty …
Clinical and cost-effectiveness of a home-based health promotion intervention for older people with mild frailty in England: a multicentre, parallel-group, randomised controlled trial.
Walters K, Frost R, Avgerinou C, Kalwarowsky S, Goodman C, Clegg A, Marston L, Pan S, Hopkins J, Jowett C, Elaswarapu R, Gardner B, Mahmood F, Prescott M, Thornton G, Skelton DA, Gould RL, Cooper C, Drennan VM, Kharicha K, Logan P, Hunter R. Walters K, et al. Among authors: clegg a. Lancet Healthy Longev. 2025 Feb;6(2):100670. doi: 10.1016/j.lanhl.2024.100670. Epub 2025 Feb 24. Lancet Healthy Longev. 2025. PMID: 40015296 Free article. Clinical Trial.
BACKGROUND: Health promotion for people with mild frailty has the potential to improve health outcomes, but such services are scarce in practice. ...HomeHealth should be considered as a health promotion intervention for older people with mild frailty. …
BACKGROUND: Health promotion for people with mild frailty has the potential to improve health outcomes, but such services are …
Metformin and physical performance in older people with probable sarcopenia and physical prefrailty or frailty in England (MET-PREVENT): a double-blind, randomised, placebo-controlled trial.
Witham MD, McDonald C, Wilson N, Rennie KJ, Bardgett M, Bradley P, Clegg AP, Connolly S, Hancock H, Hiu S, Nicholson K, Robertson L, Simms L, Steel AJ, Steves CJ, Storey B, Wason J, von Zglinicki T, Sayer AA. Witham MD, et al. Among authors: clegg ap. Lancet Healthy Longev. 2025 Mar;6(3):100695. doi: 10.1016/j.lanhl.2025.100695. Epub 2025 Mar 24. Lancet Healthy Longev. 2025. PMID: 40147475 Free article. Clinical Trial.
BACKGROUND: Metformin has effects on multiple biological systems relevant to ageing and has been posited as a candidate therapy for sarcopenia and physical frailty. We aimed to test the efficacy and safety of metformin, a candidate geroprotector, to improve physical perfor …
BACKGROUND: Metformin has effects on multiple biological systems relevant to ageing and has been posited as a candidate therapy for sarcopen …
Community based complex interventions to sustain independence in older people: systematic review and network meta-analysis.
Crocker TF, Ensor J, Lam N, Jordão M, Bajpai R, Bond M, Forster A, Riley RD, Andre D, Brundle C, Ellwood A, Green J, Hale M, Mirza L, Morgan J, Patel I, Patetsini E, Prescott M, Ramiz R, Todd O, Walford R, Gladman J, Clegg A. Crocker TF, et al. Among authors: clegg a. BMJ. 2024 Mar 21;384:e077764. doi: 10.1136/bmj-2023-077764. BMJ. 2024. PMID: 38514079 Free PMC article.
ELIGIBILITY CRITERIA: Randomised controlled trials or cluster randomised controlled trials with 24 weeks' follow-up studying community based complex interventions for sustaining independence in older people (mean age 65 years) living at home, with usual care, placebo, or a …
ELIGIBILITY CRITERIA: Randomised controlled trials or cluster randomised controlled trials with 24 weeks' follow-up studying community based …
A scoping review of the measurement and analysis of frailty in randomised controlled trials.
Sun Y, Witham MD, Clegg A, Taylor RS, Dibben G, McAllister D, Hanlon P. Sun Y, et al. Among authors: clegg a. Age Ageing. 2024 Nov 1;53(11):afae258. doi: 10.1093/ageing/afae258. Age Ageing. 2024. PMID: 39572393 Free PMC article.
METHODS: We searched five electronic databases for RCTs in which frailty was measured among trial participants. We extracted data on intervention type, the frailty measure used and the purpose for which frailty was assessed. ...CONCLUSION: Frailty meas …
METHODS: We searched five electronic databases for RCTs in which frailty was measured among trial participants. We extracted data on …
111 results