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PART is part of Alzheimer disease.
Duyckaerts C, Braak H, Brion JP, Buée L, Del Tredici K, Goedert M, Halliday G, Neumann M, Spillantini MG, Tolnay M, Uchihara T. Duyckaerts C, et al. Acta Neuropathol. 2015 May;129(5):749-56. doi: 10.1007/s00401-015-1390-7. Epub 2015 Jan 28. Acta Neuropathol. 2015. PMID: 25628035 Free PMC article.
It has been proposed that tau aggregation confined to entorhinal cortex and hippocampus, with no or only minimal Abeta deposition, should be considered as a 'primary age-related tauopathy' (PART) that is not integral to the continuum of sporadic Alzheimer disease …
It has been proposed that tau aggregation confined to entorhinal cortex and hippocampus, with no or only minimal Abeta deposition, should be …
Amyloid-beta peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer's disease with APPdup and Down syndrome.
Kasri A, Camporesi E, Gkanatsiou E, Boluda S, Brinkmalm G, Stimmer L, Ge J, Hanrieder J, Villain N, Duyckaerts C, Vermeiren Y, Pape SE, Nicolas G, Laquerrière A, De Deyn PP, Wallon D, Blennow K, Strydom A, Zetterberg H, Potier MC. Kasri A, et al. Among authors: duyckaerts c. Acta Neuropathol. 2024 Jul 18;148(1):8. doi: 10.1007/s00401-024-02756-4. Acta Neuropathol. 2024. PMID: 39026031 Free PMC article.
Alzheimer's disease (AD) is characterized by extracellular amyloid plaques containing amyloid-beta (Abeta) peptides, intraneuronal neurofibrillary tangles, extracellular neuropil threads, and dystrophic neurites surrounding plaques composed of hyperphosphorylated ta …
Alzheimer's disease (AD) is characterized by extracellular amyloid plaques containing amyloid-beta (Abeta) peptides, intraneur …
Creating the Pick's disease International Consortium: Association study of MAPT H2 haplotype with risk of Pick's disease.
Valentino RR, Scotton WJ, Roemer SF, Lashley T, Heckman MG, Shoai M, Martinez-Carrasco A, Tamvaka N, Walton RL, Baker MC, Macpherson HL, Real R, Soto-Beasley AI, Mok K, Revesz T, Warner TT, Jaunmuktane Z, Boeve BF, Christopher EA, DeTure M, Duara R, Graff-Radford NR, Josephs KA, Knopman DS, Koga S, Murray ME, Lyons KE, Pahwa R, Parisi JE, Petersen RC, Whitwell J, Grinberg LT, Miller B, Schlereth A, Seeley WW, Spina S, Grossman M, Irwin DJ, Lee EB, Suh E, Trojanowski JQ, Van Deerlin VM, Wolk DA, Connors TR, Dooley PM, Frosch MP, Oakley DH, Aldecoa I, Balasa M, Gelpi E, Borrego-Écija S, de Eugenio Huélamo RM, Gascon-Bayarri J, Sánchez-Valle R, Sanz-Cartagena P, Piñol-Ripoll G, Molina-Porcel L, Bigio EH, Flanagan ME, Gefen T, Rogalski EJ, Weintraub S, Redding-Ochoa J, Chang K, Troncoso JC, Prokop S, Newell KL, Ghetti B, Jones M, Richardson A, Robinson AC, Roncaroli F, Snowden J, Allinson K, Green O, Rowe JB, Singh P, Beach TG, Serrano GE, Flowers XE, Goldman JE, Heaps AC, Leskinen SP, Teich AF, Black SE, Keith JL, Masellis M, Bodi I, King A, Sarraj SA, Troakes C, Halliday GM, Hodges JR, Kril JJ, Kwok JB, Piguet O, Gearing M, Arzberger T, Roeber S, Attems J, Morris CM, Thomas AJ, Ever… See abstract for full author list ➔ Valentino RR, et al. Among authors: duyckaerts c. medRxiv [Preprint]. 2023 Apr 24:2023.04.17.23288471. doi: 10.1101/2023.04.17.23288471. medRxiv. 2023. Update in: Lancet Neurol. 2024 May;23(5):487-499. doi: 10.1016/S1474-4422(24)00083-8. PMID: 37163045 Free PMC article. Updated. Preprint.
BACKGROUND: Pick's disease (PiD) is a rare and predominantly sporadic form of frontotemporal dementia that is classified as a primary tauopathy. ...The MAPT H2 haplotype has consistently been associated with a decreased disease risk of the 4-repeat tauopathies of pr …
BACKGROUND: Pick's disease (PiD) is a rare and predominantly sporadic form of frontotemporal dementia that is classified as a primary …
Chemically-defined camelid antibody bioconjugate for the magnetic resonance imaging of Alzheimer's disease.
Vandesquille M, Li T, Po C, Ganneau C, Lenormand P, Dudeffant C, Czech C, Grueninger F, Duyckaerts C, Delatour B, Dhenain M, Lafaye P, Bay S. Vandesquille M, et al. Among authors: duyckaerts c. MAbs. 2017 Aug/Sep;9(6):1016-1027. doi: 10.1080/19420862.2017.1342914. Epub 2017 Jun 28. MAbs. 2017. PMID: 28657418 Free PMC article.
Here, we selected a VHH (R3VQ) specifically targeting one of the main lesions of Alzheimer's disease (AD), namely the amyloid-beta (Ass) deposits. It was used as a scaffold for the design of imaging probes for magnetic resonance imaging (MRI) and labeled with the co …
Here, we selected a VHH (R3VQ) specifically targeting one of the main lesions of Alzheimer's disease (AD), namely the amyloid- …
Iatrogenic Creutzfeldt-Jakob disease with Amyloid-beta pathology: an international study.
Cali I, Cohen ML, Haik S, Parchi P, Giaccone G, Collins SJ, Kofskey D, Wang H, McLean CA, Brandel JP, Privat N, Sazdovitch V, Duyckaerts C, Kitamoto T, Belay ED, Maddox RA, Tagliavini F, Pocchiari M, Leschek E, Appleby BS, Safar JG, Schonberger LB, Gambetti P. Cali I, et al. Among authors: duyckaerts c. Acta Neuropathol Commun. 2018 Jan 8;6(1):5. doi: 10.1186/s40478-017-0503-z. Acta Neuropathol Commun. 2018. PMID: 29310723 Free PMC article.
The presence of pathology related to the deposition of amyloid-beta (Abeta) has been recently reported in iatrogenic Creutzfeldt-Jakob disease (iCJD) acquired from inoculation of growth hormone (GH) extracted from human cadaveric pituitary gland or use of cadaveric dura ma …
The presence of pathology related to the deposition of amyloid-beta (Abeta) has been recently reported in iatrogenic Creutzfeldt-Jakob di …
Dissociation of Alzheimer type pathology in a disconnected piece of cortex.
Duyckaerts C, Uchihara T, Seilhean D, He Y, Hauw JJ. Duyckaerts C, et al. Acta Neuropathol. 1997 May;93(5):501-7. doi: 10.1007/s004010050645. Acta Neuropathol. 1997. PMID: 9144589
A woman with Alzheimer's disease died at the age of 85 years. A left sphenoid meningioma had been removed 27 years earlier. The tumor and the operation had severely altered the white matter of the frontal lobe and of the anterior part of the temporal lobe on …
A woman with Alzheimer's disease died at the age of 85 years. A left sphenoid meningioma had been removed 27 years earlier. Th …
Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation.
Papegaey A, Eddarkaoui S, Deramecourt V, Fernandez-Gomez FJ, Pantano P, Obriot H, Machala C, Anquetil V, Camuzat A, Brice A, Maurage CA, Le Ber I, Duyckaerts C, Buée L, Sergeant N, Buée-Scherrer V. Papegaey A, et al. Among authors: duyckaerts c. Acta Neuropathol Commun. 2016 Jul 19;4(1):74. doi: 10.1186/s40478-016-0345-0. Acta Neuropathol Commun. 2016. PMID: 27435172 Free PMC article.
To address this question, we have analyzed Tau expression in the frontal brain areas from control, Alzheimer's disease and FTLD cases, including FTLD- Tau (MAPT), FTLD-TDP (sporadic, FTLD-TDP-GRN, FTLD-TDP-C9ORF72) and sporadic FTLD-FUS, using western blot and 2D-DI …
To address this question, we have analyzed Tau expression in the frontal brain areas from control, Alzheimer's disease and FTL …
The extent of neurofibrillary pathology in perforant pathway neurons is the key determinant of dementia in the very old.
García-Sierra F, Hauw JJ, Duyckaerts C, Wischik CM, Luna-Muñoz J, Mena R. García-Sierra F, et al. Among authors: duyckaerts c. Acta Neuropathol. 2000 Jul;100(1):29-35. doi: 10.1007/s004010051189. Acta Neuropathol. 2000. PMID: 10912917
Neurofibrillary pathology as found in Alzheimer's disease (AD) is also found in the normal elderly, suggesting that these changes may be part of the aging process. ...
Neurofibrillary pathology as found in Alzheimer's disease (AD) is also found in the normal elderly, suggesting that these chan …
Cytoarchitectonic alterations in the supramarginal gyrus of late onset Alzheimer's disease.
Grignon Y, Duyckaerts C, Bennecib M, Hauw JJ. Grignon Y, et al. Among authors: duyckaerts c. Acta Neuropathol. 1998 Apr;95(4):395-406. doi: 10.1007/s004010050816. Acta Neuropathol. 1998. PMID: 9560018 Clinical Trial.
The neuronal loss predominated in layers II and III (upper part). A multivariate analysis showed that the intellectual status was better correlated with the density of the tangles than with the neuronal loss....
The neuronal loss predominated in layers II and III (upper part). A multivariate analysis showed that the intellectual status was bet …
Laminar spongiosis of the dentate gyrus: a sign of disconnection, present in cases of severe Alzheimer's disease.
Duyckaerts C, Colle MA, Seilhean D, Hauw JJ. Duyckaerts C, et al. Acta Neuropathol. 1998 Apr;95(4):413-20. doi: 10.1007/s004010050818. Acta Neuropathol. 1998. PMID: 9560020
An extensive laminar spongiosis was found in the outer part of the dentate gyrus in an 84-year-old patient. An old cavitary infarct in the parahippocampal gyrus disconnected the dentate gyrus from the entorhinal area. This finding prompted us to seek laminar spongiosis in …
An extensive laminar spongiosis was found in the outer part of the dentate gyrus in an 84-year-old patient. An old cavitary infarct i …
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