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Page 1
Frailty in older adults: evidence for a phenotype.
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA; Cardiovascular Health Study Collaborative Research Group. Fried LP, et al. J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56. doi: 10.1093/gerona/56.3.m146. J Gerontol A Biol Sci Med Sci. 2001. PMID: 11253156
METHODS: To develop and operationalize a phenotype of frailty in older adults and assess concurrent and predictive validity, the study used data from the Cardiovascular Health Study. ...CONCLUSIONS: This study provides a potential standardized definition for …
METHODS: To develop and operationalize a phenotype of frailty in older adults and assess concurrent and predictive vali …
Frailty: implications for clinical practice and public health.
Hoogendijk EO, Afilalo J, Ensrud KE, Kowal P, Onder G, Fried LP. Hoogendijk EO, et al. Among authors: fried lp. Lancet. 2019 Oct 12;394(10206):1365-1375. doi: 10.1016/S0140-6736(19)31786-6. Lancet. 2019. PMID: 31609228 Review.
Studies have shown a clear pattern of increased health-care costs and use associated with frailty. All older adults are at risk of developing frailty, although risk levels are substantially higher among those with comorbidities, low socioeconomic posit …
Studies have shown a clear pattern of increased health-care costs and use associated with frailty. All older adults are …
Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management.
Dent E, Morley JE, Cruz-Jentoft AJ, Woodhouse L, Rodríguez-Mañas L, Fried LP, Woo J, Aprahamian I, Sanford A, Lundy J, Landi F, Beilby J, Martin FC, Bauer JM, Ferrucci L, Merchant RA, Dong B, Arai H, Hoogendijk EO, Won CW, Abbatecola A, Cederholm T, Strandberg T, Gutiérrez Robledo LM, Flicker L, Bhasin S, Aubertin-Leheudre M, Bischoff-Ferrari HA, Guralnik JM, Muscedere J, Pahor M, Ruiz J, Negm AM, Reginster JY, Waters DL, Vellas B. Dent E, et al. Among authors: fried lp. J Nutr Health Aging. 2019;23(9):771-787. doi: 10.1007/s12603-019-1273-z. J Nutr Health Aging. 2019. PMID: 31641726 Free PMC article.
OBJECTIVE: The task force of the International Conference of Frailty and Sarcopenia Research (ICFSR) developed these clinical practice guidelines to overview the current evidence-base and to provide recommendations for the identification and management of frailty in …
OBJECTIVE: The task force of the International Conference of Frailty and Sarcopenia Research (ICFSR) developed these clinical practic …
Frailty consensus: a call to action.
Morley JE, Vellas B, van Kan GA, Anker SD, Bauer JM, Bernabei R, Cesari M, Chumlea WC, Doehner W, Evans J, Fried LP, Guralnik JM, Katz PR, Malmstrom TK, McCarter RJ, Gutierrez Robledo LM, Rockwood K, von Haehling S, Vandewoude MF, Walston J. Morley JE, et al. Among authors: fried lp. J Am Med Dir Assoc. 2013 Jun;14(6):392-7. doi: 10.1016/j.jamda.2013.03.022. J Am Med Dir Assoc. 2013. PMID: 23764209 Free PMC article.
Frailty can occur as the result of a range of diseases and medical conditions. A consensus group consisting of delegates from 6 major international, European, and US societies created 4 major consensus points on a specific form of frailty: physical frailty. 1 …
Frailty can occur as the result of a range of diseases and medical conditions. A consensus group consisting of delegates from 6 major …
Frailty as a predictor of surgical outcomes in older patients.
Makary MA, Segev DL, Pronovost PJ, Syin D, Bandeen-Roche K, Patel P, Takenaga R, Devgan L, Holzmueller CG, Tian J, Fried LP. Makary MA, et al. Among authors: fried lp. J Am Coll Surg. 2010 Jun;210(6):901-8. doi: 10.1016/j.jamcollsurg.2010.01.028. Epub 2010 Apr 28. J Am Coll Surg. 2010. PMID: 20510798
STUDY DESIGN: We prospectively measured frailty in 594 patients (age 65 years or older) presenting to a university hospital for elective surgery between July 2005 and July 2006. ...CONCLUSIONS: Frailty independently predicts postoperative complications, lengt …
STUDY DESIGN: We prospectively measured frailty in 594 patients (age 65 years or older) presenting to a university hospital fo …
The Asia-Pacific Clinical Practice Guidelines for the Management of Frailty.
Dent E, Lien C, Lim WS, Wong WC, Wong CH, Ng TP, Woo J, Dong B, de la Vega S, Hua Poi PJ, Kamaruzzaman SBB, Won C, Chen LK, Rockwood K, Arai H, Rodriguez-Mañas L, Cao L, Cesari M, Chan P, Leung E, Landi F, Fried LP, Morley JE, Vellas B, Flicker L. Dent E, et al. Among authors: fried lp. J Am Med Dir Assoc. 2017 Jul 1;18(7):564-575. doi: 10.1016/j.jamda.2017.04.018. J Am Med Dir Assoc. 2017. PMID: 28648901
OBJECTIVE: To develop Clinical Practice Guidelines for the screening, assessment and management of the geriatric condition of frailty. METHODS: An adapted Grading of Recommendations, Assessment, Development, and Evaluation approach was used to develop the guidelines. ...CO …
OBJECTIVE: To develop Clinical Practice Guidelines for the screening, assessment and management of the geriatric condition of frailty …
The physical frailty syndrome as a transition from homeostatic symphony to cacophony.
Fried LP, Cohen AA, Xue QL, Walston J, Bandeen-Roche K, Varadhan R. Fried LP, et al. Nat Aging. 2021 Jan;1(1):36-46. doi: 10.1038/s43587-020-00017-z. Epub 2021 Jan 14. Nat Aging. 2021. PMID: 34476409 Free PMC article.
Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence on the aging-related pathophysiology underpinning the clinical presentation of physical fra …
Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to adverse outcomes when exposed to stresso …
Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care.
Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Fried LP, et al. J Gerontol A Biol Sci Med Sci. 2004 Mar;59(3):255-63. doi: 10.1093/gerona/59.3.m255. J Gerontol A Biol Sci Med Sci. 2004. PMID: 15031310 Review.
Three terms are commonly used interchangeably to identify vulnerable older adults: comorbidity, or multiple chronic conditions, frailty, and disability. However, in geriatric medicine, there is a growing consensus that these are distinct clinical entities tha …
Three terms are commonly used interchangeably to identify vulnerable older adults: comorbidity, or multiple chronic conditions …
Inflammation and frailty in older women.
Leng SX, Xue QL, Tian J, Walston JD, Fried LP. Leng SX, et al. Among authors: fried lp. J Am Geriatr Soc. 2007 Jun;55(6):864-71. doi: 10.1111/j.1532-5415.2007.01186.x. J Am Geriatr Soc. 2007. PMID: 17537086
PARTICIPANTS: Five hundred fifty-eight women aged 65 to 101 from WHAS I and 548 women aged 70 to 79 from the merged WHAS I and II cohorts. ...Furthermore, participants in the top tertiles of WBC count and IL-6 had an OR of 9.85 (95% CI=3.04-31.99), and those in the …
PARTICIPANTS: Five hundred fifty-eight women aged 65 to 101 from WHAS I and 548 women aged 70 to 79 from the merged WHAS I and …
Cortisol and Dehydroepiandrosterone Response to Adrenocorticotropic Hormone and Frailty in Older Women.
Le NP, Varadhan R, Fried LP, Cappola AR. Le NP, et al. Among authors: fried lp. J Gerontol A Biol Sci Med Sci. 2021 Apr 30;76(5):901-905. doi: 10.1093/gerona/glaa134. J Gerontol A Biol Sci Med Sci. 2021. PMID: 32502234 Free PMC article.
BACKGROUND: The response to adrenocorticotropic hormone (ACTH) is poorly characterized in old-old adults and may provide insight into the physiologic response to stress. METHOD: We performed a standard 250 g ACTH stimulation test in a home-based substudy of 51 women age …
BACKGROUND: The response to adrenocorticotropic hormone (ACTH) is poorly characterized in old-old adults and may provide insight into …
93 results