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2013 1
2017 1
2021 0
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Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.
Kell DB. Kell DB. FEBS J. 2013 Dec;280(23):5957-80. doi: 10.1111/febs.12268. Epub 2013 Apr 22. FEBS J. 2013. PMID: 23552054 Free article. Review.
Leaving aside regulatory matters, the fundamental and interlinked intellectual issues proposed to be largely responsible for this are: (a) the move from 'function-first' to 'target-first' methods of screening and drug discovery; (b) the belief that successful drugs …
Leaving aside regulatory matters, the fundamental and interlinked intellectual issues proposed to be largely responsible for this are: (a) t …
Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine.
Grixti JM, O'Hagan S, Day PJ, Kell DB. Grixti JM, et al. Among authors: kell db. Front Pharmacol. 2017 Mar 27;8:155. doi: 10.3389/fphar.2017.00155. eCollection 2017. Front Pharmacol. 2017. PMID: 28396636 Free PMC article.
The transport of drug molecules is mainly determined by the distribution of influx and efflux transporters for which they are substrates. ...The experimental system tested the ability of a molecule that on its own had no cytotoxic effect to increase the toxic …
The transport of drug molecules is mainly determined by the distribution of influx and efflux transporters for which th …