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Ubiquitin is phosphorylated by PINK1 to activate parkin.
Koyano F, Okatsu K, Kosako H, Tamura Y, Go E, Kimura M, Kimura Y, Tsuchiya H, Yoshihara H, Hirokawa T, Endo T, Fon EA, Trempe JF, Saeki Y, Tanaka K, Matsuda N. Koyano F, et al. Nature. 2014 Jun 5;510(7503):162-6. doi: 10.1038/nature13392. Epub 2014 Jun 4. Nature. 2014. PMID: 24784582
Our results show that PINK1-dependent phosphorylation of both parkin and ubiquitin is sufficient for full activation of parkin E3 activity. These findings demonstrate that phosphorylated ubiquitin is a parkin
Our results show that PINK1-dependent phosphorylation of both parkin and ubiquitin is sufficient for full act
Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL.
Koyano F, Yamano K, Kosako H, Tanaka K, Matsuda N. Koyano F, et al. J Biol Chem. 2019 Jun 28;294(26):10300-10314. doi: 10.1074/jbc.RA118.006302. Epub 2019 May 20. J Biol Chem. 2019. PMID: 31110043 Free PMC article.
PINK1, a Ser/Thr kinase that accumulates only on impaired mitochondria, phosphorylates two authentic substrates, the ubiquitin-like domain of Parkin and ubiquitin. ...Parkin then supplies a ubiquitin chain to PINK1 for ph
PINK1, a Ser/Thr kinase that accumulates only on impaired mitochondria, phosphorylates two authentic substrates, the ubiqui
Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.
Iguchi M, Kujuro Y, Okatsu K, Koyano F, Kosako H, Kimura M, Suzuki N, Uchiyama S, Tanaka K, Matsuda N. Iguchi M, et al. Among authors: koyano f. J Biol Chem. 2013 Jul 26;288(30):22019-32. doi: 10.1074/jbc.M113.467530. Epub 2013 Jun 10. J Biol Chem. 2013. PMID: 23754282 Free PMC article.
Furthermore, formation of the ubiquitin-ester depends on PINK1 phosphorylation of Parkin Ser-65. ...We propose that PINK1-dependent phosphorylation of Parkin leads to the ubiquitin-ester transfer reaction of the RING2 domain …
Furthermore, formation of the ubiquitin-ester depends on PINK1 phosphorylation of Parkin Ser-65. ...We propose t …
Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation.
Yamano K, Queliconi BB, Koyano F, Saeki Y, Hirokawa T, Tanaka K, Matsuda N. Yamano K, et al. Among authors: koyano f. J Biol Chem. 2015 Oct 16;290(42):25199-211. doi: 10.1074/jbc.M115.671446. Epub 2015 Aug 10. J Biol Chem. 2015. PMID: 26260794 Free PMC article.
Recent progress has revealed that phosphorylation of both Parkin and ubiquitin at Ser(65) by PINK1 are crucial for activation and recruitment of Parkin to the damaged mitochondria. However, the mechanism by which phosphorylated
Recent progress has revealed that phosphorylation of both Parkin and ubiquitin at Ser(65) by PINK1 are crucial f …
Molecular mechanisms underlying PINK1 and Parkin catalyzed ubiquitylation of substrates on damaged mitochondria.
Koyano F, Matsuda N. Koyano F, et al. Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2791-6. doi: 10.1016/j.bbamcr.2015.02.009. Epub 2015 Feb 18. Biochim Biophys Acta. 2015. PMID: 25700839 Free article. Review.
PINK1 is a protein kinase and Parkin is a ubiquitin ligase (E3) that links ubiquitin to a substrate. ...Second, in response to a decrease in mitochondrial membrane potential, PINK1 phosphorylates Ser65 in both the Parkin ubiquit
PINK1 is a protein kinase and Parkin is a ubiquitin ligase (E3) that links ubiquitin to a substrate. ...Second,
The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons.
Koyano F, Okatsu K, Ishigaki S, Fujioka Y, Kimura M, Sobue G, Tanaka K, Matsuda N. Koyano F, et al. Genes Cells. 2013 Aug;18(8):672-81. doi: 10.1111/gtc.12066. Epub 2013 Jun 10. Genes Cells. 2013. PMID: 23751051 Free PMC article.
We found that dissipation of the mitochondrial membrane potential triggers phosphorylation of both PINK1 and Parkin and that, in response, Parkin translocates to depolarized mitochondria. Furthermore, Parkin's E3 activity is re-est …
We found that dissipation of the mitochondrial membrane potential triggers phosphorylation of both PINK1 and Parkin and …