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Ubiquitin is phosphorylated by PINK1 to activate parkin.
Koyano F, Okatsu K, Kosako H, Tamura Y, Go E, Kimura M, Kimura Y, Tsuchiya H, Yoshihara H, Hirokawa T, Endo T, Fon EA, Trempe JF, Saeki Y, Tanaka K, Matsuda N. Koyano F, et al. Nature. 2014 Jun 5;510(7503):162-6. doi: 10.1038/nature13392. Epub 2014 Jun 4. Nature. 2014. PMID: 24784582
Our results show that PINK1-dependent phosphorylation of both parkin and ubiquitin is sufficient for full activation of parkin E3 activity. These findings demonstrate that phosphorylated ubiquitin is a parkin …
Our results show that PINK1-dependent phosphorylation of both parkin and ubiquitin is sufficient for full act …
Molecular mechanisms underlying PINK1 and Parkin catalyzed ubiquitylation of substrates on damaged mitochondria.
Koyano F, Matsuda N. Koyano F, et al. Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2791-6. doi: 10.1016/j.bbamcr.2015.02.009. Epub 2015 Feb 18. Biochim Biophys Acta. 2015. PMID: 25700839 Free article. Review.
PINK1 and Parkin are gene products that cause genetic recessive Parkinsonism. PINK1 is a protein kinase and Parkin is a ubiquitin ligase (E3) that links ubiquitin to a substrate. ...Second, in response to a decrease in mitochondrial membr …
PINK1 and Parkin are gene products that cause genetic recessive Parkinsonism. PINK1 is a protein kinase and Parkin …
Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL.
Koyano F, Yamano K, Kosako H, Tanaka K, Matsuda N. Koyano F, et al. J Biol Chem. 2019 Jun 28;294(26):10300-10314. doi: 10.1074/jbc.RA118.006302. Epub 2019 May 20. J Biol Chem. 2019. PMID: 31110043 Free PMC article.
PINK1, a Ser/Thr kinase that accumulates only on impaired mitochondria, phosphorylates two authentic substrates, the ubiquitin-like domain of Parkin and ubiquitin. Our group and others have revealed that both the subcellular localization and lig …
PINK1, a Ser/Thr kinase that accumulates only on impaired mitochondria, phosphorylates two authentic substrates, the ubiqui …
Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation.
Yamano K, Queliconi BB, Koyano F, Saeki Y, Hirokawa T, Tanaka K, Matsuda N. Yamano K, et al. Among authors: koyano f. J Biol Chem. 2015 Oct 16;290(42):25199-211. doi: 10.1074/jbc.M115.671446. Epub 2015 Aug 10. J Biol Chem. 2015. PMID: 26260794 Free PMC article.
Recent progress has revealed that phosphorylation of both Parkin and ubiquitin at Ser(65) by PINK1 are crucial for activation and recruitment of Parkin to the damaged mitochondria. However, the mechanism by which phosphorylated …
Recent progress has revealed that phosphorylation of both Parkin and ubiquitin at Ser(65) by PINK1 are crucial f …
Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.
Iguchi M, Kujuro Y, Okatsu K, Koyano F, Kosako H, Kimura M, Suzuki N, Uchiyama S, Tanaka K, Matsuda N. Iguchi M, et al. Among authors: koyano f. J Biol Chem. 2013 Jul 26;288(30):22019-32. doi: 10.1074/jbc.M113.467530. Epub 2013 Jun 10. J Biol Chem. 2013. PMID: 23754282 Free PMC article.
PINK1 and PARKIN are causal genes for autosomal recessive familial Parkinsonism. PINK1 is a mitochondrial Ser/Thr kinase, whereas Parkin functions as an E3 ubiquitin ligase. ...We propose that PINK1-dependent phosphorylation of …
PINK1 and PARKIN are causal genes for autosomal recessive familial Parkinsonism. PINK1 is a mitochondrial Ser/Thr kinas …
The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons.
Koyano F, Okatsu K, Ishigaki S, Fujioka Y, Kimura M, Sobue G, Tanaka K, Matsuda N. Koyano F, et al. Genes Cells. 2013 Aug;18(8):672-81. doi: 10.1111/gtc.12066. Epub 2013 Jun 10. Genes Cells. 2013. PMID: 23751051 Free PMC article.
We found that dissipation of the mitochondrial membrane potential triggers phosphorylation of both PINK1 and Parkin and that, in response, Parkin translocates to depolarized mitochondria. Furthermore, Parkin's E3 activity is re-est …
We found that dissipation of the mitochondrial membrane potential triggers phosphorylation of both PINK1 and Parkin and …