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Page 1
The hallmarks of aging.
López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. López-Otín C, et al. Cell. 2013 Jun 6;153(6):1194-217. doi: 10.1016/j.cell.2013.05.039. Cell. 2013. PMID: 23746838 Free PMC article. Review.
This Review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging. ...A major challenge is to dissect the interconnectedness between the candidate hallmarks and …
This Review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with speci …
Hallmarks of aging: An expanding universe.
López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. López-Otín C, et al. Cell. 2023 Jan 19;186(2):243-278. doi: 10.1016/j.cell.2022.11.001. Epub 2023 Jan 3. Cell. 2023. PMID: 36599349 Free article. Review.
Aging is driven by hallmarks fulfilling the following three premises: (1) their age-associated manifestation, (2) the acceleration of aging by experimentally accentuating them, and (3) the opportunity to decelerate, stop, or reverse aging by therapeuti …
Aging is driven by hallmarks fulfilling the following three premises: (1) their age-associated manifestation, (2) the accelera …
Meta-hallmarks of aging and cancer.
López-Otín C, Pietrocola F, Roiz-Valle D, Galluzzi L, Kroemer G. López-Otín C, et al. Cell Metab. 2023 Jan 3;35(1):12-35. doi: 10.1016/j.cmet.2022.11.001. Cell Metab. 2023. PMID: 36599298 Free article. Review.
Both aging and cancer are characterized by a series of partially overlapping "hallmarks" that we subject here to a meta-analysis. Several hallmarks of aging (i.e., genomic instability, epigenetic alterations, chronic inflammation, and dysbiosis) are ve …
Both aging and cancer are characterized by a series of partially overlapping "hallmarks" that we subject here to a meta-analys …
From geroscience to precision geromedicine: Understanding and managing aging.
Kroemer G, Maier AB, Cuervo AM, Gladyshev VN, Ferrucci L, Gorbunova V, Kennedy BK, Rando TA, Seluanov A, Sierra F, Verdin E, López-Otín C. Kroemer G, et al. Among authors: lopez otin c. Cell. 2025 Apr 17;188(8):2043-2062. doi: 10.1016/j.cell.2025.03.011. Cell. 2025. PMID: 40250404 Free PMC article. Review.
Major progress has been made in elucidating the molecular, cellular, and supracellular mechanisms underlying aging. This has spurred the birth of geroscience, which aims to identify actionable hallmarks of aging. Aging can be viewed as a process that i …
Major progress has been made in elucidating the molecular, cellular, and supracellular mechanisms underlying aging. This has spurred …
Hallmarks of Health.
López-Otín C, Kroemer G. López-Otín C, et al. Cell. 2021 Jan 7;184(1):33-63. doi: 10.1016/j.cell.2020.11.034. Epub 2020 Dec 18. Cell. 2021. PMID: 33340459 Free article. Review.
Here, we endeavor to define health as a compendium of organizational and dynamic features that maintain physiology. The biological causes or hallmarks of health include features of spatial compartmentalization (integrity of barriers and containment of local perturbations), …
Here, we endeavor to define health as a compendium of organizational and dynamic features that maintain physiology. The biological causes or …
Exercise sustains the hallmarks of health.
Qiu Y, Fernández-García B, Lehmann HI, Li G, Kroemer G, López-Otín C, Xiao J. Qiu Y, et al. Among authors: lopez otin c. J Sport Health Sci. 2023 Jan;12(1):8-35. doi: 10.1016/j.jshs.2022.10.003. Epub 2022 Oct 29. J Sport Health Sci. 2023. PMID: 36374766 Free PMC article. Review.
Here we mainly summarize how moderate-intensity exercise affects the major hallmarks of health, including the integrity of barriers, containment of local perturbations, recycling and turnover, integration of circuitries, rhythmic oscillations, homeostatic resilience, horme …
Here we mainly summarize how moderate-intensity exercise affects the major hallmarks of health, including the integrity of barriers, …
Exercise attenuates the hallmarks of aging: Novel perspectives.
Qiu Y, Fernández-García B, Lehmann HI, Li G, Kroemer G, López-Otín C, Xiao J. Qiu Y, et al. Among authors: lopez otin c. J Sport Health Sci. 2025 Dec 4;15:101108. doi: 10.1016/j.jshs.2025.101108. Online ahead of print. J Sport Health Sci. 2025. PMID: 41352451 Free PMC article. Review.
Among these, regular physical exercise is strongly associated with numerous health benefits and is recognized as a key strategy for promoting healthy aging and extending healthspan. In this review, we highlight the impact of an active lifestyle, particularly regular physic …
Among these, regular physical exercise is strongly associated with numerous health benefits and is recognized as a key strategy for promotin …
Aging and cancer.
Montégut L, López-Otín C, Kroemer G. Montégut L, et al. Among authors: lopez otin c. Mol Cancer. 2024 May 18;23(1):106. doi: 10.1186/s12943-024-02020-z. Mol Cancer. 2024. PMID: 38760832 Free PMC article. Review.
Aging and cancer exhibit apparent links that we will examine in this review. The null hypothesis that aging and cancer coincide because both are driven by time, irrespective of the precise causes, can be confronted with the idea that aging and cancer share co …
Aging and cancer exhibit apparent links that we will examine in this review. The null hypothesis that aging and cancer coincid …
The hallmarks of aging as a conceptual framework for health and longevity research.
Tartiere AG, Freije JMP, López-Otín C. Tartiere AG, et al. Among authors: lopez otin c. Front Aging. 2024 Jan 15;5:1334261. doi: 10.3389/fragi.2024.1334261. eCollection 2024. Front Aging. 2024. PMID: 38292053 Free PMC article. Review.
In this context, The Hallmarks of Aging were defined in 2013 with the aim of establishing an organized, systematic and integrative view of this topic, which would serve as a conceptual framework for aging research. ...For this aim, we have reviewed the litera …
In this context, The Hallmarks of Aging were defined in 2013 with the aim of establishing an organized, systematic and integra …
Exercise and the hallmarks of cardiovascular aging.
Zhong D, Fernández-García B, Gokulnath P, Lin K, Li G, Kroemer G, López-Otín C, Xiao J. Zhong D, et al. Among authors: lopez otin c. Ageing Res Rev. 2026 Mar;115:103030. doi: 10.1016/j.arr.2026.103030. Epub 2026 Jan 22. Ageing Res Rev. 2026. PMID: 41580156 Review.
Cardiovascular diseases (CVDs), including hypertension, heart failure, atherosclerosis and myocardial infarction, remain the leading cause of morbidity and mortality worldwide. Aging is a predominant risk factor for CVD. Cardiovascular aging is characterized by prog …
Cardiovascular diseases (CVDs), including hypertension, heart failure, atherosclerosis and myocardial infarction, remain the leading cause o …
21 results